El papel de la vitamina D en la gestación y la preeclampsia: de la biología molecular a la clínica
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Palabras clave

vitamina D
colecalciferol
gestación
preeclampsia
calcitriol (DeCS)
vitamin D
cholecalciferol
gestation
calcitriol (MeSH)

Cómo citar

Agudelo Zapata, Y., Cortés-Vásquez, J. A., Linares Vaca, A. F., Mancera Rodríguez, C. A., Perea-Ariza, S. A., Ramírez Iriarte, K. Y., Castro Saldarriaga, C. A., Ángel Muller, E., Parada Baños, A. J., & Caminos Pinzón, J. E. (2017). El papel de la vitamina D en la gestación y la preeclampsia: de la biología molecular a la clínica. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 3(2), 22–36. https://doi.org/10.53853/encr.3.2.30

Resumen

Los niveles séricos de vitamina D bajos se han asociado con un riesgo elevado de preeclampsia, una de las principales causas de mortalidad materna en Colombia y el mundo. La asociación parte del papel de la vitamina D en la inflamación y de su relación con el eje renina-angiotensina-aldosterona. El Instituto de Salud de los Estados Unidos sugiere que la vitamina D debe suplementarse de forma rutinaria durante el control prenatal; sin embargo, la Organización Mundial de la Salud, respaldada en medicina basada en la evidencia, sugiere la no suplementación de rutina de esta vitamina. En Colombia, no se conoce la prevalencia de la deficiencia o insuficiencia de vitamina D y los puntos de corte de normalidad aún son objeto de discusión. El objetivo del presente artículo es el de presentar una revisión desde la bases de la biología molecular a la clínica, dilucidando el papel de la vitamina D en la gestación y en su relación con la preeclampsia, así como el de invitar al desarrollo de programas de investigación en temas relacionados con la vitamina D en el país.

Abstract
The low serum levels of vitamin D have been associated with the risk of preeclampsia, a leading cause of maternal mortality in Colombia. The biological plausibility of the association is the vitamin D role in inflammation and its relationship with the renin-angiotensin-aldosterone axis. The Institute of Medicine of the United States suggests that vitamin D should be supplemented routinely during antenatal care, however, the World Health Organization, supported by evidence-based medicine, suggests not supplement it. In Colombia, the prevalence of deficiency or insufficiency of vitamin D is not known and even normal break- points are discussed. The aim of this article is to review from the molecular biology to the clinic, elucidating the role of vitamin D during pregnancy and in the genesis of preeclampsia, and to encourage research in this field in the country.

https://doi.org/10.53853/encr.3.2.30
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Citas

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