Valores de pruebas tiroideas (TSH y T4 libre) en una población adulta de la ciudad de Medellín, Colombia

  • Carlos Alfonso Builes Barrera Dinámica IPS
  • Joanna Milena Márquez Fernández Universidad de Antioquia
  • Rosa María Gómez Baena Dinámica IPS
  • Magda Liliana Cárdenas Gómez Dinámica IPS

Resumen

Contexto: Los valores de referencia para pruebas tiroideas deben estandarizarse en la población local. En Colombia no tenemos datos propios.
Objetivo: Describir los niveles de hormonas tiroideas (TSH y T4 libre) en adultos de Medellín, Colombia.
Métodos: Estudio retrospectivo, con información obtenida de la base de datos electrónica de Dinámica IPS.
Criterios de inclusión: Adultos (18-50 años), con medición simultánea de TSH y T4 libre (T4L), ambos dentro del valor de referencia suministrado por el proveedor de la prueba (Abbott).
Criterios de exclusión: mujeres embarazadas, hipotiroidismo primario conocido y anticuerpos anti-TPO o antitiroglobulina positivos. Los datos se compararon con una curva normal. Se realizó un análisis de regresión lineal entre T4L y TSH o LogTSH.
Resultados: Se obtuvieron datos desde febrero 1 hasta abril 30 de 2015, n = 2.438 personas, el 80,5% eran mujeres, el promedio de edad 35,74±8,4 años. El promedio de TSH fue 2,19±1,10 mUI/L y el de T4L 1,00±0,11 ng/dl. Los valores de T4L se distribuyen de forma normal, pero los de TSH se distribuyeron como una curva asintótica hacia la izquierda. El 95% de los valores de T4L fueron entre 0,74-1,26 ng/dl y de TSH entre 0,36 y 4,55 mUI/L. No hubo diferencias entre TSH y T4 libre por sexo o por edad. El análisis de regresión lineal no mostró relación entre la T4L y TSH o LogTSH.
Conclusiones: En adultos entre 18 a 50 años, el 95% de los valores de TSH oscilan entre 0,36-4,55 mUI/ L y para T4 L entre 0,74-1,26 ng/dl. No hubo diferencias por sexo o décadas de edad. Tampoco entre valores de TSH y T4L.

Abstract
Context: Reference values for thyroid tests should be standardized in local adult people. In Colombia we do not have own data.
Objective: To describe serum levels of thyroid hormones (TSH and free T4) in adults from Medellin, Colombia.
Methods: Retrospective study based in information from an electronic database.
Inclusion criteria: Adults 18-50 years-old adults with simultaneous measurement of TSH and free T4 (FT4), both values within the reference value supplied by Abbot.
Exclusion criteria: pregnant women, primary hypothyroidism and positive TPO or thyroglobulin antibodies. Data were compared with a normal curve. Linear regression analysis between FT4 and TSH and between FT4 and LogTSH was performed.
Results: Data from February 1 to April 30 2015 were obtained, n=2.438 individuals, 80.5% were women, age mean±SD35.74±8.4 years. TSH values were mean±SD 2.19±1.10 mUI/L and FT4 1.00±0.11 ng/dl. FT4 were distributed as a normal curve, meanwhile TSH showed an asymptotic curve to the left. Ninety five percent of FT4 values were between 0.74-1.26 ng/dl and TSH 0.36-4.55 mUI/L. There was no difference between TSH and FT4 by gender or by age. Linear regression analysis do not showed any relationship between TSH and FT4.
Conclusions: In adult population 95% of serum TSH and FT4 ranging between 0.36-4.55 uUI/L and 0.74-1.26 ng/dl respectively. There were no differences by gender or age groups, or relationship between TSH and FT4.

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Biografía del autor

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Endocrinólogo de Adultos Hospital Universitario San Vicente Fundación. Docente en la Sección de Endocrinología y Metabolismo Universidad de Antioquia. Medellín, Colombia. Asesor Científico: Sección de Endocrinología, Laboratorio Dinámica IPS.

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Residente de Endocrinología y Metabolismo y Especialista en Medicina Interna Universidad de Antioquia.

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Asesora Técnica Laboratorio Dinámica IPS.

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Bacterióloga. Jefe de Laboratorio Clínico Regional. Dinámica IPS.

Citas

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Publicado
2017-03-21
##submission.howToCite##
BUILES BARRERA, Carlos Alfonso et al. Valores de pruebas tiroideas (TSH y T4 libre) en una población adulta de la ciudad de Medellín, Colombia. Revista Colombiana de Endocrinología, Diabetes & Metabolismo, [S.l.], v. 2, n. 4, p. 20-24, mar. 2017. ISSN 2389-9786. Disponible en: <http://revistaendocrino.org/index.php/rcedm/article/view/46>. Fecha de acceso: 09 dic. 2019
Sección
Articulos Originales