Keywords
Accidental Falls
Coronavirus
Cardiovascular Diseases
Bone Fractures
Vitamin D
Coronavirus
Cardiovascular Diseases
Bone Fractures
Vitamin D
How to Cite
Rosero-Olarte, O. (2021). Risk of high-dose vitamin D use in the elderly during COVID 19 pandemic. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 7(3), 178–181. https://doi.org/10.53853/encr.7.3.630
Abstract
Vitamin D has been considered a panacea and cure for several diseases, although the number of well-conducted intervention studies has been scarce or even contradictory. At the current time of the COVID-19 pandemic, some voices have been raised to recommend high doses for infection control and treatment. The objective of this review is to provide information regarding the potential risks and adverse events of highdose vitamin D. In the light of current evidence, it is essential to keep vitamin D levels within normal ranges, it is generally accepted that values between 30 and 40 ng/mL are sufficient for most of the older adult population, which is where the COVID-19 affects it most severely.
References
1. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017;18(2):153-65. doi: 10.1007/s11154-017-9424-1
2. Chiodini I, Bolland MJ. Calcium supplementation in osteoporosis: useful or harmful? 2018;178(4):D13-D25. doi: 10.1530/EJE-18-0113
3. Grant WB, Lahore H, Mc Donnell SL, Baggerly C, French C, Aliano J, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. doi: 10.3390/nu12040988
4. Garland CF, Kim JJ, Mohr SB, Burgette S, Gorham E, Grant W, et al. Metaanalysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D. Am J Public Health. 2014;104(8):e43-50. doi: 10.2105/AJPH.2014.302034
5. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Int Med. 2008;168(15):1629-37. doi: 10.1001/archinte.168.15.1629
6. Jia X, Aucott LS, McNeill G. Nutritional status and subsequent all-cause mortality in men and women aged 75 years or over living in the community. Br J Nutr. 2007;98(3):593-9. doi: 10.1017/S0007114507725163
7. Sempos CT, Durazo-Arvizu RA, Dawson-Hughes B, Yetley E, Looker A, Schleicher R, et al. Is there a Reverse J-shaped Association between 25-Hydroxyvitamin D and All-Cause Mortality. Results from the US Nationally Representative NHANES. J Clin Endocrinol Metabol. 2013:98(7):3001-9. doi: 10.1210/jc.2013-1333
8. Dror Y, Giveon SM, Hoshen M, Feldhamer I, Balicer R, Feldman B, et al. Vitamin d levels for preventing acute coronary syndrome and mortality: evidence of a nonlinear association. J Clin Endocrinol Metabol. 2013;98(5):2160-7. doi: 10.1210/jc.2013-1185
9. Durup D, Jorgensen HL, Christensen J, Schwarz P, Heegaard A, Lind B. A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study. J Clin Endocrinol Metabol. 2012;97(8):2644-52. doi: 10.1210/jc.2012-1176.
10. Amrein K, Quraishi SA, Litonjua AA, Gibbons F, Pieber T, Camargo C, et al. Evidence for a U-shaped relationship between prehospital vitamin D status and mortality: a cohort study. J Clin Endocrinol Metab. 2014;99(4):1461- 9. doi: 10.1210/jc.2013-3481
11. Mellenthin L, Wallaschofski H, Grotevendt A, Völzke H, Nauck M, Hannemann A. Association between serum vitamin D concentrations and inflammatory markers in the general adult population. Metabolism. 2014;63(8):1056-62. doi: 10.1016/j.metabol.2014.05.002
12. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G, et al. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation. 2005;112(17):2627-33. doi: 10.1161/CIRCULATIONAHA.105.553198
13. Litonjua A. Childhood asthma may be a consequence of vitamin D deficiency. Curr Opin Allergy Clin Immunol. 2009;9(3):202-7. doi: 10.1097/ ACI.0b013e32832b36cd
14. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4(2):80-90. doi: 10.1038/ncpendmet0716
15. Chishimba L, Thickett D, Stockley R, Wood A. The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax. 2010;65(5):456- 62. doi: 10.1136/thx.2009.128793
16. Hansen S, Maslova E, Strom M, Linneberg A, Halldorsson T, Granström, et al. The long-term programming effect of maternal 25hydroxyvitamin D in pregnancy on allergic airway disease and lung function offspring after 20 to 25 years of follow-up. J Allergy Clin Immunol. 2015;136(1):169-76. doi: 10.1016/j.jaci.2014.12.1924
17. van Oeffelen A, Bekkers M, Smit H, Kerkhof M, Koppelman G, HavemanNies A, et al. Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol. 2011;22(8):784- 93. doi: 10.1111/j.1399-3038.2011.01190.x
18. Rothers J, Wright al, Stern DA, Halonen M, Camargo C. Cord blood 25-hydroxyvitamin D levels are associated with aeroallergen sensitization in children from Tucson, Arizona. J Allergy Clin Immunol. 2011;128(5):1093- 9. doi: 10.1016/j.jaci.2011.07.015
19. Gale C, Robinson SM, Harvey NC, Jiang J, Martyn C, Godfrey K, et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr. 2008;62(1):68-77. doi: 10.1038/sj.ejcn.1602680
20. Janssen HC, Samson MM, Verhaar HJ. Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr. 2002;75(4):611-5. doi: 10.1093/ajcn/75.4.611
21. Bischoff-Ferrari HA, Borchers M, Gudat F, Dürmüller U, Stähelin H, Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res. 2004;19(2):265-9. doi: 10.1359/jbmr.2004.19.2.265
22. Dawson H. Vitamin D and muscle function. J Steroid Biochem Mol Biol. 2017;173:313-6. doi: 10.1016/j.jsbmb.2017.03.018
23. Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck A, Staehelin H, Orav E, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Internal Med. 2009;169(6):551-61. doi: 10.1001/archinternmed.2008.600
24. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005;293(18):2257- 64. doi: 10.1001/jama.293.18.2257
25. Bischoff-Ferrari HA. Vitamin D and fracture prevention. Rheum Dis Clin North Am. 2012;38(1):107-13. doi: 10.1016/j.rdc.2012.03.010
26. Boonen S, Bischoff-Ferrari HA, Cooper C, Lips P, Ljunggren O, Meunier P, et al. Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int. 2006;78(5):257-70. doi: 10.1007/s00223-005-0009-8
27. Anders KM, Stuart AL, Williamson EJ, Simpson J, Kotowicz M, Young D, et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010;303(18):1815-22. doi: 10.1001/jama.2010.594
28. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer O, Theiler R, et al. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016;176(2):175-83. doi: 10.1001/jamainternmed.2015.7148
29. Vásquez D, Cano C, Gómez A, González M, Guzmán R, Martínez J, et al. Vitamina D. Consenso colombiano de expertos. Medicina. 2017;39(2):140- 57.
30. Yomayusa-González N, Low-Padilla E, Oliveros-Velásquez JD, MendivelsoDuarte F, Gómez-Gómez O, Castilla-Gutiérrez A, et al. Recomendaciones para el uso racional de la prueba 25-hidroxi vitamina D Policy Brief. Rev Colomb Nefrol. 2019;6(2):179-92.
2. Chiodini I, Bolland MJ. Calcium supplementation in osteoporosis: useful or harmful? 2018;178(4):D13-D25. doi: 10.1530/EJE-18-0113
3. Grant WB, Lahore H, Mc Donnell SL, Baggerly C, French C, Aliano J, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. doi: 10.3390/nu12040988
4. Garland CF, Kim JJ, Mohr SB, Burgette S, Gorham E, Grant W, et al. Metaanalysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D. Am J Public Health. 2014;104(8):e43-50. doi: 10.2105/AJPH.2014.302034
5. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Int Med. 2008;168(15):1629-37. doi: 10.1001/archinte.168.15.1629
6. Jia X, Aucott LS, McNeill G. Nutritional status and subsequent all-cause mortality in men and women aged 75 years or over living in the community. Br J Nutr. 2007;98(3):593-9. doi: 10.1017/S0007114507725163
7. Sempos CT, Durazo-Arvizu RA, Dawson-Hughes B, Yetley E, Looker A, Schleicher R, et al. Is there a Reverse J-shaped Association between 25-Hydroxyvitamin D and All-Cause Mortality. Results from the US Nationally Representative NHANES. J Clin Endocrinol Metabol. 2013:98(7):3001-9. doi: 10.1210/jc.2013-1333
8. Dror Y, Giveon SM, Hoshen M, Feldhamer I, Balicer R, Feldman B, et al. Vitamin d levels for preventing acute coronary syndrome and mortality: evidence of a nonlinear association. J Clin Endocrinol Metabol. 2013;98(5):2160-7. doi: 10.1210/jc.2013-1185
9. Durup D, Jorgensen HL, Christensen J, Schwarz P, Heegaard A, Lind B. A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study. J Clin Endocrinol Metabol. 2012;97(8):2644-52. doi: 10.1210/jc.2012-1176.
10. Amrein K, Quraishi SA, Litonjua AA, Gibbons F, Pieber T, Camargo C, et al. Evidence for a U-shaped relationship between prehospital vitamin D status and mortality: a cohort study. J Clin Endocrinol Metab. 2014;99(4):1461- 9. doi: 10.1210/jc.2013-3481
11. Mellenthin L, Wallaschofski H, Grotevendt A, Völzke H, Nauck M, Hannemann A. Association between serum vitamin D concentrations and inflammatory markers in the general adult population. Metabolism. 2014;63(8):1056-62. doi: 10.1016/j.metabol.2014.05.002
12. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G, et al. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation. 2005;112(17):2627-33. doi: 10.1161/CIRCULATIONAHA.105.553198
13. Litonjua A. Childhood asthma may be a consequence of vitamin D deficiency. Curr Opin Allergy Clin Immunol. 2009;9(3):202-7. doi: 10.1097/ ACI.0b013e32832b36cd
14. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4(2):80-90. doi: 10.1038/ncpendmet0716
15. Chishimba L, Thickett D, Stockley R, Wood A. The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax. 2010;65(5):456- 62. doi: 10.1136/thx.2009.128793
16. Hansen S, Maslova E, Strom M, Linneberg A, Halldorsson T, Granström, et al. The long-term programming effect of maternal 25hydroxyvitamin D in pregnancy on allergic airway disease and lung function offspring after 20 to 25 years of follow-up. J Allergy Clin Immunol. 2015;136(1):169-76. doi: 10.1016/j.jaci.2014.12.1924
17. van Oeffelen A, Bekkers M, Smit H, Kerkhof M, Koppelman G, HavemanNies A, et al. Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol. 2011;22(8):784- 93. doi: 10.1111/j.1399-3038.2011.01190.x
18. Rothers J, Wright al, Stern DA, Halonen M, Camargo C. Cord blood 25-hydroxyvitamin D levels are associated with aeroallergen sensitization in children from Tucson, Arizona. J Allergy Clin Immunol. 2011;128(5):1093- 9. doi: 10.1016/j.jaci.2011.07.015
19. Gale C, Robinson SM, Harvey NC, Jiang J, Martyn C, Godfrey K, et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr. 2008;62(1):68-77. doi: 10.1038/sj.ejcn.1602680
20. Janssen HC, Samson MM, Verhaar HJ. Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr. 2002;75(4):611-5. doi: 10.1093/ajcn/75.4.611
21. Bischoff-Ferrari HA, Borchers M, Gudat F, Dürmüller U, Stähelin H, Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res. 2004;19(2):265-9. doi: 10.1359/jbmr.2004.19.2.265
22. Dawson H. Vitamin D and muscle function. J Steroid Biochem Mol Biol. 2017;173:313-6. doi: 10.1016/j.jsbmb.2017.03.018
23. Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck A, Staehelin H, Orav E, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Internal Med. 2009;169(6):551-61. doi: 10.1001/archinternmed.2008.600
24. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005;293(18):2257- 64. doi: 10.1001/jama.293.18.2257
25. Bischoff-Ferrari HA. Vitamin D and fracture prevention. Rheum Dis Clin North Am. 2012;38(1):107-13. doi: 10.1016/j.rdc.2012.03.010
26. Boonen S, Bischoff-Ferrari HA, Cooper C, Lips P, Ljunggren O, Meunier P, et al. Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int. 2006;78(5):257-70. doi: 10.1007/s00223-005-0009-8
27. Anders KM, Stuart AL, Williamson EJ, Simpson J, Kotowicz M, Young D, et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010;303(18):1815-22. doi: 10.1001/jama.2010.594
28. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer O, Theiler R, et al. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016;176(2):175-83. doi: 10.1001/jamainternmed.2015.7148
29. Vásquez D, Cano C, Gómez A, González M, Guzmán R, Martínez J, et al. Vitamina D. Consenso colombiano de expertos. Medicina. 2017;39(2):140- 57.
30. Yomayusa-González N, Low-Padilla E, Oliveros-Velásquez JD, MendivelsoDuarte F, Gómez-Gómez O, Castilla-Gutiérrez A, et al. Recomendaciones para el uso racional de la prueba 25-hidroxi vitamina D Policy Brief. Rev Colomb Nefrol. 2019;6(2):179-92.
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