Calciferoles: las hormonas del momento
PDF (Español (España))
HTML (Español (España))

Keywords

Calcipherols
vitamin D
antirachitic factor
vitamin D receptor
cod liver oil

How to Cite

Jácome, A. (2019). Calciferoles: las hormonas del momento. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 6(4), 318–324. https://doi.org/10.53853/encr.6.4.551

Abstract

Discovery of calciferols was done after rachitism was recognized and studied. Herodotus link bone strength to sun light. Rachitism epidemics affected England and Scotland during second decade of the seventeenth century, making Glisson to describe the disease in 1650. In 1918, Mellamby discovered the cause, worried about the UK epidemics. Following McCollum ideas, he thought rachitism would be a nutritional deficiency. He examined scottish diet, and fed dogs with oat flour, putting them away from sun light. Once rachitic, they were cured with cod liver oil. He thought of vitamin A as the cause of the disease. McCollum then found in 1922 a second lipid-soluble factor responsible of bone calcification and named it vitamin D, as the fourth vitamin. Calciferols study showed that they were eminently diet compounds, essentials vitamins. They were later studied as hormones (DeLucca) but discovery of its receptor widened his action and is now regarded as an immunomodulator.

https://doi.org/10.53853/encr.6.4.551
PDF (Español (España))
HTML (Español (España))

References

1. Ardila E, Sierra O. Hormonas calciotróficas y metabolismo óseo. En: Jácome A, Ardila E, Casas LA. Fisiología endocrina. 4.a edición. Bogotá: Manual Moderno; 2017. p. 156-89.
2. Iglesias A, Restrepo JF, Toro CE. Historia de la Vitamina D. Barranquilla: Universidad Simón Bolívar; 2008.
3. Iglesias A, Restrepo JF. Historia de los mecanismos fisiológicos y bioquímicos de la vitamina D. Rev Colomb Reumatol. 2005;12(2):107-40.
4. Jácome Roca A. Historia de las hormonas. Bogotá: Academia Nacional de Medicina de Colombia; 2008.
5. The Nobel Prize and the discovery of vitamins. NobelPrize.org. [citado 25 de octubre de 2019]. Disponible en:
https://www.nobelprize.org/prizes/themes/the-nobel-prize-and-the-discovery-of-vitamins-2.
6. The Nobel Prize in Chemistry 1928. NobelPrize.org. [citado 25 de octubre de 2019]. Disponible en:
https://www.nobelprize.org/prizes/chemistry/1928/windaus/lecture/.
7. University of California Riverside. History of vitamin D. Disponible en: http:/vitamind.ucr.edu/about.html.
8. Vitamin A Saga. The Weston A. Price Foundation. [citado 25 de octubre de 2019]. Disponible en:
https://www.westonaprice.org/health-topics/abcs-of-nutrition/vitamin-a-saga/.
9. Hernigou P, Auregan JC, Dubory A. Vitamin D: part II; cod liver oil, ultraviolet radiation, and eradication of rickets. Int Orthop. 2019;43(3):735-49.
10. Jones G. The discovery and synthesis of the nutritional factor vitamin D. Int J Paleopathol. 2018;23:96-9.
11. Hopkins FG. The earlier history in vitamin research. The Nobel Prize in Physiology or Medicine 1929 [Internet]. NobelPrize.org. [citado 25 de octubre de 2019]. Disponible en: https://www.nobelprize.org/prizes/medicine/1929/hopkins/lecture/.
12. DeLuca HF. Vitamin D endocrinology. Ann Intern Med. 1976;85(3):367-77.
13. Holt LE. A tribute to Elmer V. McCollum. Am J Clin Nutr. 1968;21(10):1136-7.
14. Jácome Roca A. La Emulsión de Scott en la Cultura Hispanoamericana. Medicina (Ac.Col). 2005;27(2):122-7.
15. Sommer A. Vitamin A, new imperatives for an old vitamin. J Nutrit. 1989;119:96-100.
16. Hernigou P, Sitbon J, Dubory A, Auregan JC. Vitamin D history part III: the “modern times”-new questions for orthopaedic practice: deficiency, cell therapy, osteomalacia, fractures, supplementation, infections. Int Orthop. 2019;43(7):1755-71.
17. Skrobot A, Demkow U, Wachowska M. Immunomodulatory Role of Vitamin D: A Review. Adv Exp Med Biol. 2018;1108:13-23.

Authors must state that they reviewed, validated and approved the manuscript's publication.  Moreover, they must sign a model release that should be sent.  A copy may be reviewed here

Dimensions


PlumX


Downloads

Download data is not yet available.