@article{Serrano_Hernández_Hung_Lozano_Paoli_Gómez_2019, title={Testicular histopathology of rats BIOU: Wistar exposed to malathion}, volume={6}, url={https://revistaendocrino.org/index.php/rcedm/article/view/544}, DOI={10.53853/encr.6.4.544}, abstractNote={<p><strong>Objective:</strong> To determine the histopathology of the testes of BIOU: Wistar rats chronically exposed to malathion compared to non-exposed rats. <br> <strong>Methods:</strong> Experimental study with 20 male rats randomized, 10 to the control group and 10 to the exposed group. The exposure consisted in the chronic application of inhaled malathion once a week for 2 hours for 14 weeks, with equivalent doses to those used by humans in agriculture. The control group was exposed to a placebo (distilled water) in the open air for the same interval time. Afterwards, they were sacrificed, a serum sample was obtained for the determination of acetylcholinesterase and the testicles were extracted for histopathological study. <br> <strong>Results:</strong> Acetylcholinesterase levels were significantly lower (p = 0.0001) in the exposed group than in the control group. In the histopathological study with light microscopy, in the exposed group, vacuolation of the germinal epithelium was observed in 50 % of the cases (p = 0.016) for an odds ratio of 3.00 (95 %:1.46- 6.13), as well as incomplete spermatogenesis in 40 % (p = 0.043) for an odds ratio of 2.66 (95 %:1.41-5.02), while there were no alterations in the control group. There was a significant inverse correlation (p = 0, 0001) between the number of histopathological alterations and acetylcholinesterase activity. <br> <strong>Conclusions:</strong> These results show that chronic exposure to malathion in BIOU: Wistar rats can produce deleterious effects on their reproductive system.</p>}, number={4}, journal={Revista Colombiana de Endocrinología, Diabetes & Metabolismo}, author={Serrano, R. and Hernández, G. A. and Hung, S. and Lozano, R. and Paoli, M. and Gómez, R.}, year={2019}, month={Dec.}, pages={252–259} }