@article{Román González_Padilla Zambrano_López Montoya_Gutiérrez_Builes-Barrera_2022, title={Genetic causes of acromegalia: a narrative review}, volume={9}, url={https://revistaendocrino.org/index.php/rcedm/article/view/737}, DOI={10.53853/encr.9.2.737}, abstractNote={<p><strong>Context:  </strong>Acromegaly is caused in most cases by growth hormone-producing pituitary tumors. These tumors usually occur in a sporadic context or rarely, associated with a hereditary syndrome. In recent years, the landscape of family mutations and syndromes associated with acromegaly and gigantism has expanded.</p> <p><strong>Objective</strong>: The aim of this review focus on the current knowledge of the genetic bases causing familial acromegaly.</p> <p><strong>Methods</strong>: Medical electronic databases and endocrine textbooks were reviewed. Genetic causes of acromegaly are presented.</p> <p><strong>Results</strong>: The genetic causes of acromegaly are diseases such as Carney Complex, multiple endocrine neoplasia type 1, familial isolated pituitary tumors (FIPA), X-linked acrogigantism (XLAG), familial pituitary adenomas with pheochromocytoma/paraganglioma (3P), McCune Albright syndrome and neurofibromatosis.</p> <p><strong>Conclusions</strong>: Multiple endocrine neoplasia should be rule out in all cases of acromegaly though calcium and parathyroid hormone measurement. All patients should have a complete family history ruling out FIPA. Also, in patients presenting at a young age other genetic causes of acromegaly must be sought.</p>}, number={2}, journal={Revista Colombiana de Endocrinología, Diabetes & Metabolismo}, author={Román González , Alejandro and Padilla Zambrano , Huber Said and López Montoya, Vanessa and Gutiérrez , Johnayro and Builes-Barrera , Carlos Alfonso}, year={2022}, month={Mar.} }