https://revistaendocrino.org/index.php/rcedm Revista Colombiana de Endocrinología, Diabetes y Metabolismo Asociación Colombiana de Endocrinología, Diabetes y Metabolismo en-US Revista Colombiana de Endocrinología, Diabetes & Metabolismo 2389-9786 <p>Authors must state that they reviewed, validated and approved the manuscript's publication. &nbsp;Moreover, they must sign a model release that should be sent. &nbsp;A copy may be reviewed <a style="outline: none; color: #323a32; text-decoration: none;" href="http://actamedicacolombiana.com/docs/CartaCD.pdf">here</a></p> https://revistaendocrino.org/index.php/rcedm/article/view/981 <p><strong>Background:</strong> Iodine-refractory differentiated thyroid carcinoma (IRDTC) is associated with increased recurrence, metastatic disease, and mortality. Sorafenib and lenvatinib are approved in IDC for the treatment of locally unresectable disease and/or progressive metastatic disease, considering their positive impact on progression-free survival (PFS) and disease control. However, some patients develop resistance from the outset or after initiating these treatments.</p> <p><strong>Objective:</strong> To identify the molecular resistance mechanisms described to these tyrosine kinase inhibitors (TKIs) in IDC.</p> <p><strong>Methodology:</strong> A literature search was conducted, including articles in English or Spanish, all study types, and studies from the past 15 years. The PICO search strategy was: thyroid cancer OR thyroid carcinoma OR thyroid neoplasms AND sorafenib OR lenvatinib AND resistance OR non-response OR therapeutic failure. It does not present ethical implications.</p> <p><strong>Results:</strong> Three studies reported resistance to sorafenib and one to lenvatinib in IDC.</p> <p><strong>Conclusions:</strong> The identified resistance mechanisms were decreased miR-124/506, increased TSP-1 and TFG? induced by tumor pericytes, and KRAS and TERT mutations.</p> Andrés Flórez Romero Yesid Camilo Hurtado Amézquita Carlos Arturo Revérénd Copyright (c) 2026 Revista Colombiana de Endocrinología, Diabetes & Metabolismo http://creativecommons.org/licenses/by-nc-nd/4.0 2026-05-27 2026-05-27 13 2 10.53853/encr.13.2.981 https://revistaendocrino.org/index.php/rcedm/article/view/967 <p><strong>Introduction: </strong>Anorexia nervosa is a psychiatric disorder that entails serious somatic sequelae, including endocrine and cardiovascular involvement. One of its rarest and most severe manifestations is polyserositis, which demands prompt clinical management.</p> <p><strong>Objective: </strong>To describe a case of anorexia nervosa complicated by polyserositis and profound endocrine dysfunction, emphasizing the diagnostic process, multidisciplinary management, and clinical evolution.</p> <p><strong>Case presentation: </strong>A 17-year-old female adolescent presented with a 10-month history of progressive weight loss, amenorrhea, cold intolerance, and autonomic symptoms. She was admitted after a syncopal episode with signs of shock—hypotension, bradycardia, and cachexia. Transthoracic echocardiography revealed a moderate-to-severe pericardial effusion with hemodynamic compromise, necessitating pericardiectomy and drainage. An exudative pleural effusion was also documented. Rheumatologic and oncologic work-ups were negative. Endocrine assessment showed hypogonadotropic hypogonadism, suppressed insulin-like growth factor-1 (IGF-1), elevated growth hormone levels, and dysregulation of the thyrotropic axis, all in the context of severe malnutrition. A progressive nutritional rehabilitation program was instituted, achieving a weekly weight gain of 600 g, which led to normalization of the hormonal profile and complete clinical resolution.</p> <p><strong>Discussion: </strong>Polyserositis in anorexia nervosa is a rare yet potentially life-threatening presentation. Its pathophysiology involves prolonged malnutrition, neuroendocrine dysfunction, and cardiovascular alterations. Diagnostic evaluation must rule out infectious, neoplastic, and autoimmune etiologies and should be conducted within a multidisciplinary framework.</p> <p><strong>Conclusion: </strong>This case underscores the need to consider anorexia nervosa as an underlying cause of polyserositis in severely malnourished adolescents. Monitored nutritional rehabilitation and a coordinated multidisciplinary approach were pivotal to achieving clinical and hormonal recovery.</p> Aura María Salazar Solarte Wilfredo Antonio Rivera-Martínez Cristina Vernaza Obando Jose Mauricio González Murillo Yesit Bolaños Moreno Alin Abreu Lomba Copyright (c) 2026 Revista Colombiana de Endocrinología, Diabetes & Metabolismo http://creativecommons.org/licenses/by-nc-nd/4.0 2026-05-26 2026-05-26 13 2 10.53853/encr.13.2.967