Central diabetes insipidus secondary to hypophysitis. Report of two cases
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Diabetes Insipidus
Arginine Vasopressin

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Tovar, H., Flórez, A., Quintero, G., & Concha, D. (2021). Central diabetes insipidus secondary to hypophysitis. Report of two cases. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 7(4), 294–300. https://doi.org/10.53853/encr.7.4.657


Diabetes insipidus is a rare entity characterized by a deficiency in the secretion of the antidiuretic hormone (ADH) or resistance to its action, which causes an alteration in concentrating diuresis, consequently, high volumes of diluted urine. Diabetes insipidus can be of renal or central origin and the latter is the most frequent. Polyuria and polydipsia are the predominant clinical expressions in response to the patient’s inability to maintain a water balance. The causes of central diabetes insipidus are diverse, such as after pituitary surgery, pituitary adenoma, ischemic encephalopathy, trauma, hypophysitis, genetic or idiopathic origin. Primary hypophysitis is a rare entity, characterized by an inflammatory process of the pituitary gland, that affects the anterior and/or posterior pituitary function. We presented two cases of patients with diabetes insipidus secondary to hypophysitis studied on outpatient and inpatient

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