Keywords
Deficiency
Newborn
Pregnancy
Risk factors
How to Cite
Abstract
Objective: to examine the prevalence of hypovitaminosis D in pregnant women and their newborns in Bogotá, Colombia.
Methods: A cross-sectional study was performed measuring the 25-hydroxyvitamin D (25(OH)D) levels in maternal blood and cord blood by chemiluminescent immunoassay. Peripheral blood samples were obtained when cord blood levels were <30 ng/mL.
Results: The study included 88 blood samples from pregnant women, 90 cord blood samples (two twin births), and 43 peripheral neonatal blood samples. According to the ranges established by the Global Consensus of the European Society for Pediatric Endocrinology (ESPE), the prevalence of hypovitaminosis D were 26%, 34%, and 67% in pregnant women, umbilical cord, and neonates, respectively. According to ranges by the Endocrine Society, the prevalence was 66%, 83%, and 100%, respectively. Maternal 25(OH)D levels were found to be correlated with neonatal levels (Spearman's Rho 0.67, p <0.001). According to the ESPE and Endocrine Society cut-off points, between 12.3% and 56.7% of neonates born to mothers with vitamin D sufficiency, had hypovitaminosis D.
Conclusions: The prevalence of hypovitaminosis D was high in pregnant women and neonates. Sufficient levels of vitamin D in the maternal sample did not guarantee adequate levels in this neonatal sample. The estimation of prevalence varies depending on which international diagnostic criteria guidelines are used.
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