Effect of liraglutide on serum androgen levels and sexual function in obese women
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Keywords

Obesity
women
Androgens
Sexual Health
Quality of Life

How to Cite

De la Hoz, F. E. (2022). Effect of liraglutide on serum androgen levels and sexual function in obese women. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 8(3). https://doi.org/10.53853/encr.8.3.685

Abstract

Objective. To analyze the variations in serum androgen levels and sexual function in women with obesity, after treatment with liraglutide and to establish their impact on quality of life.

Methods. Prospective, quasi-experimental pilot study, developed in 15 women with obesity; treated with liraglutide, between January and October 2020; in a private level III clinic in Armenia (Colombia). The serum levels of Total Testosterone (Tt), Free Testosterone (Tl), Androstenedione (A) and SHBG (Sex hormone binding globulin) were quantified. The Female Sexual Function Index (IFSF) instruments and the SF-36 Health Questionnaire were used. Four follow-ups were carried out (at the beginning, at four, eight and twelve weeks later). Descriptive statistics were applied.

Results. The average age was 37.41 ± 5.28 years (lower 27 and higher 45). The mean serum androgen levels at baseline were: Tt (0.39 ± 0.12 ng / ml), Tl (5.49 ± 1.37 pg / ml), A (2.58 ± 1.13 ng / ml) and SHBG (26.94 ± 13.74 ng / ml), and at the end: Tt (0.81 ± 0.15 ng / ml), Tl (12.57 ± 3.89 pg / ml), A (3.87 ± 1.28 ng / ml) and SHBG (49.62 ± 15.57 ng / ml), (p <0.05). The mean score of the SF-36 Health Questionnaire at the beginning was 63.91 ± 15.19 and at the end it was 79.63 ± 15.13 (p <0.05). The IFSF at the beginning was 23.47 ± 6.97 and at the end of 27.97 ± 6.45 (p <0.05). A clear improvement was observed in both sexual function and quality of life.

Conclusions. Liraglutide produced a significant increase in serum levels of Tt, Tl, A and SHBG; in addition to improving the sexual function and quality of life of the participating women. Liraglutide could become a promising drug for the treatment of obesity, achieving positive effects on sexual function and quality of life in women.

https://doi.org/10.53853/encr.8.3.685
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