Aggressive behavior and clinical course of parathyroid carcinoma: a case report and review of the literature
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parathyroid neoplasia
Diabetes Mellitus

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Plata Upegui , C., Hernandez Caicedo, A. J., & Plata Upegui, L. J. (2022). Aggressive behavior and clinical course of parathyroid carcinoma: a case report and review of the literature. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 9(2).


Context: Primary hyperparathyroidism, is the third most frequent endocrine disorder. It is rarely caused by parathyroid carcinoma, an infrequent entity, difficult to diagnose and with a high recurrence and mortality rate.

Objective: To present the clinical course and approach to parathyroid carcinoma, emphasizing the pre-surgical clinical suspicion criteria, which are determinant in the initial surgical planning.

Methodology: The case of a young woman with severe hypercalcemia due to parathyroid carcinoma was presented. The behavior of the disease, complications and interventions received were documented. Correlation was made with the literature review, in terms of clinical manifestations, diagnosis, therapeutic options and importance of follow-up.

Results. The feedback of the actions taken with the patient was performed. The pre-surgical suspicion criteria were highlighted, in contrast with the available imaging studies, highlighting their advantages and disadvantages. The repercussions on hypercalcemia, which pharmacological and surgical interventions have, were identified.

Conclusions: Parathyroid carcinoma is a neoplasm of difficult diagnosis and high impact on patients' lives. Pre-surgical clinical suspicion is determinant for the initial surgical approach, since the complete elimination of the disease is the therapeutic objective. Survival is related to the control of hypercalcemia and long-term clinical follow-up, due to several therapeutic interventions are available to improve life expectancy.
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