Frequency of hypophosphatasemia in the child population of the integrated subnet of the southwestern health services of Bogotá between 2018 and 2020
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alkaline phosphatase
short stature
bone mineralization

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González López, V., Torrijos, E., & Escobar Patrón, A. (2022). Frequency of hypophosphatasemia in the child population of the integrated subnet of the southwestern health services of Bogotá between 2018 and 2020. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 9(3).


Context: Alkaline phosphatase is involved in essential organic processes for survival; Although the pathological significance of its elevation is known, the clinical implications of its low levels are little recognized in daily clinical practice, despite the fact that its association with different clinical entities has been described, such as: malnutrition, hypothyroidism, anemia, chronic diseases. liver deposition and even inborn errors of metabolism such as hypophosphatasia. Objective:  The purpose of this study is to determine the frequency of hypophosphatasemia in the child population under 18 years of age in the southwestern subnetwork of Bogotá between 2018 and 2020 and to describe its demographic and clinical characteristics. Methods: Observational, cross-sectional study that analyzed 1062 medical records corresponding to FAL in children under 18 years of age over a two-year period.  Results: The frequency of hypophosphatasemia was 4.3% with a 95% CI (3.1%-5.6%). In females it was 3.5% and in males 5.4%, with a P of 0.124. The age group affected was those under 10 years of age, with a frequency of 10%. The main diagnoses related to hypophosphatasemia were malnutrition, short stature, and impaired renal function. Conclusions: Hypophosphatasemia has a low frequency in our pediatric population, which correlates with studies carried out internationally. The main diagnoses related to hypophosphatasemia are consistent with those described in the literature, such as malnutrition and short stature. Although hypophosphatasia is rare, one case was diagnosed in our population and there is one suspected case.
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