Frequency of hypophosphatasemia in the child population of the integrated subnet of the southwestern health services of Bogotá between 2018 and 2020
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alkaline phosphatase
short stature
bone mineralization

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González López, V., Torrijos, E., & Escobar Patrón, A. (2022). Frequency of hypophosphatasemia in the child population of the integrated subnet of the southwestern health services of Bogotá between 2018 and 2020. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 9(3).


Context: Alkaline phosphatase is involved in essential organic processes for survival; Although the pathological significance of its elevation is known, the clinical implications of its low levels are little recognized in daily clinical practice, despite the fact that its association with different clinical entities has been described, such as: malnutrition, hypothyroidism, anemia, chronic diseases. liver deposition and even inborn errors of metabolism such as hypophosphatasia. Objective:  The purpose of this study is to determine the frequency of hypophosphatasemia in the child population under 18 years of age in the southwestern subnetwork of Bogotá between 2018 and 2020 and to describe its demographic and clinical characteristics. Methods: Observational, cross-sectional study that analyzed 1062 medical records corresponding to FAL in children under 18 years of age over a two-year period.  Results: The frequency of hypophosphatasemia was 4.3% with a 95% CI (3.1%-5.6%). In females it was 3.5% and in males 5.4%, with a P of 0.124. The age group affected was those under 10 years of age, with a frequency of 10%. The main diagnoses related to hypophosphatasemia were malnutrition, short stature, and impaired renal function. Conclusions: Hypophosphatasemia has a low frequency in our pediatric population, which correlates with studies carried out internationally. The main diagnoses related to hypophosphatasemia are consistent with those described in the literature, such as malnutrition and short stature. Although hypophosphatasia is rare, one case was diagnosed in our population and there is one suspected case.
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Sharma, U., Pal, D., & Prasad, R. Alkaline Phosphatase: An Overview. Int J Clin Biochem Res. 2013;29(3), 269–278.

Khan A, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S et al. Hypophosphatasia: Canadian update on diagnosis and management. Osteoporosis International. 2019;30(9):1713-1722.

Bayramli R, Cevlik T, Guran T, Atay Z, Bas S, Haklar G, Bereket A, Turan S. Clinical Significance of Hypophosphatasemia in Children. Calcif Tissue Int. 2020 Jun;106(6):608-615.

Colantonio D, Kyriakopoulou L, Chan M, Daly C, Brinc D, Venner A et al. Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children. Clinical Chemistry. 2012;58(5):854-868.

Estey M, Cohen A, Colantonio D, Chan M, Marvasti T, Randell E et al. CLSI-based transference of the CALIPER database of pediatric reference intervals from Abbott to Beckman, Ortho, Roche and Siemens Clinical Chemistry Assays: Direct validation using reference samples from the CALIPER cohort. Clinical Biochemistry. 2013;46(13-14):1197-1219.

Rathbun J. "HYPOPHOSPHATASIA". American Journal of Diseases of Children. 1948;75(6):822.

Riancho-Zarrabeitia L, García-Unzueta M, Tenorio J, Gómez-Gerique J, Ruiz Pérez V, Heath K et al. Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults. European Journal of Internal Medicine. 2016;29:40-45.

Rockman-Greenberg, C. Hypophosphatasia., Pediatric endocrinology reviews?: PER. 2013 : 380–388.

Whyte, M. P. Molecular diagnosis of hypophosphatasia and differential diagnosis by targeted Next Generation Sequencing Hypophosphatasia and the Role of Alkaline Phosphatase in Skeletal Mineralization, Endocrine Reviews. Endocrine Society. 1994 (4): 439–461.

Saraff V, Narayanan V, Lawson A, Shaw N, Preece M, Högler W. A Diagnostic Algorithm for Children with Low Alkaline Phosphatase Activities: Lessons Learned from Laboratory Screening for Hypophosphatasia. The Journal of Pediatrics. 2016;172:181-186.

Rodriguez M,Hamilton I. Niveles bajos de fosfatasa alcalina en niños, Revisión retrospectiva. Rev. Hosp. Niños ( B. Aires) 2018;60 (270): 236-243.

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