Hypophysitis with normal imaging
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Autoimmune diseases
Autoimmune hypophysitis
sella turcica

How to Cite

González-Arango J., García , A. F., Estupiñán-Vargas V. ., Monsalve-Arango, C., Aguilar-Londoño C. ., Aristizabal-Henao, N. ., & Torres-Grajales, J. L. . (2022). Hypophysitis with normal imaging. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 9(4). https://doi.org/10.53853/encr.9.4.742


Background: A hypophysitis is an inflammatory disease of the pituitary gland that compromise any portion of the gland and compromise the hormonal axes. Among the primary causes, the most frequent is lymphocytic or autoimmune hypophysitis.

Purpose: To present an interesting case and it’s clinical approach.

Case presentation: In the text we present a patient with history of lupus in whom pituitary hormone deficiencies were documented with a presumptive diagnosis of autoimmune hypophysitis. The diagnosis was based on clinical and laboratory findings. Cranial images were unremarkable, ruling out differential diagnoses

Discussion and conclusion: Hypophysitis can be classified as primary or secondary depending on the underlining cause. The final diagnosis is made with the pathology report. Cranial images support the diagnosis and help to rule out differentials but there have been described cases of hypophitis with normal images. We present the diagnostic approach to pituitary hormone deficiency in a patient with autoimmune disease with suspected adenohypophysitis based on clinical symptoms, history and biochemical profile, even in the context of normal images.

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