Clinical characteristics and factors associated with amputation in patients with diabetic foot disease
Cover of our Vol. 11, Issue 2, 2024
PDF (Español (España))
html (Español (España))

Keywords

Diabetes Mellitus
Diabetes Complications
Diabetes Mellitus Type 2
Diabetic Foot
Colombia

How to Cite

Matamoros, J. M., & Barragán Barreto, S. . (2024). Clinical characteristics and factors associated with amputation in patients with diabetic foot disease. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 11(2). https://doi.org/10.53853/encr.11.2.871

Abstract

Background: Diabetic foot disease is an undesirable outcome in the course of diabetes, and it is necessary to clinically characterize local patients and identify factors associated with the need for amputation.

Purpose: Determine the clinical characteristics and factors associated with amputation of patients with Diabetic Foot disease.

Methodology: This is a retrospective cross-sectional study, based on the review of 154 medical records of patients who who were treated at the Emergency Service of the Departmental Hospital of Villavicencio, Colombia in the period from July 2022 to June 2023. The following data were collected: age, sex, clinical history, residence, blood glucose, glycosylated hemoglobin, creatinine, type and level of amputation.

Results: Of the 154 patients included, 84 (54.5%) were men, with an average age of 64.2 years, and 41 patients (26.6%) resided in rural areas. Seventy-six (49.3%) underwent amputations, with 32 (20.7%) having a toe amputation, 15 (9.7%) transtibial, and 29 (18.8%) supracondylar. Sixty-six (42.8%) were smokers, and 102 patients (66.2%) were hypertensive. The average HbA1c was 10.1%, higher in the amputated group at 11.3%. The average creatinine level was 2.3 mg/dl, with 3.5 mg/dl in the amputated group. Hypertension was present in 72.3% of the amputated patients, showing a significant association with the risk of amputation (OR 2.2, CI = 1.10 - 4.37, P = 0.0244). Additionally, there was a positive association between a history of amputation and the risk of another amputation during hospitalization (OR 3.41, CI = 1.56 - 7.45, P = 0.002).

Conclusion: Diabetic foot disease and eventual amputation is related to clinical variables such as hypertension and previous amputation associated to paraclinical variables of patients such as their glycemic control and creatinine levels.

https://doi.org/10.53853/encr.11.2.871
PDF (Español (España))
html (Español (España))

References

Boulton AJM, Armstrong DG, Albert SF, Frykberg RG, Hellman R, Kirkman MS, et al. Comprehensive Foot Examination and Risk Assessment. Diabetes Care. 2008 Aug 1;31(8):1679–85.

Schaper NC, van Netten JJ, Apelqvist J, Bus SA, Hinchliffe RJ, Lipsky BA. Practical Guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update). Diabetes Metab Res Rev. 2020 Mar 16;36(S1).

Vargas-Uricoechea H, Casas-Figueroa LÁ. Epidemiología de la diabetes mellitus en Sudamérica: la experiencia de Colombia. Clínica e Investigación en Arteriosclerosis. 2016 Sep;28(5):245–56.

Aschner P. Epidemiología de la diabetes en Colombia. Avances en Diabetología. 2010 Apr;26(2):95–100.

Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, et al. Primary Prevention of Cardiovascular Diseases in People With Diabetes Mellitus. Diabetes Care. 2007 Jan 1;30(1):162–72.

Cavender MA, Steg PhG, Smith SC, Eagle K, Ohman EM, Goto S, et al. Impact of Diabetes Mellitus on Hospitalization for Heart Failure, Cardiovascular Events, and Death. Circulation. 2015 Sep 8;132(10):923–31.

Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus. J Vasc Surg. 2011 Jan;53(1):220-226.e5.

Singh N. Preventing Foot Ulcers in Patients With Diabetes. JAMA. 2005 Jan 12;293(2):217.

Bus SA. Priorities in offloading the diabetic foot. Diabetes Metab Res Rev. 2012 Feb 23;28(S1):54–9.

Everett E, Mathioudakis N. Update on management of diabetic foot ulcers. Ann N Y Acad Sci. 2018 Jan 29;1411(1):153–65.

Palestro CJ, Love C. Nuclear Medicine and Diabetic Foot Infections. Semin Nucl Med. 2009 Jan;39(1):52–65.

Font-Jimenez I, Llauradó-Serra M, Pallarés-Martí À, García-Hedrera F. Factores psicosociales implicados en la amputación. Revisión sistemática de la literatura. Aten Primaria. 2016 Mar;48(3):207–10.

Craus S, Mula A, Coppini D V. The foot in diabetes – a reminder of an ever-present risk. Clinical Medicine. 2023 May;23(3):228–33.

Cerqueira MMB da F, Maia HMSF, Mercês MC das, Santos da Natividade M, Almeida O dos S, Santana EF, et al. Complications related to diabetic foot ulcer and associated social vulnerability factors at a referral centre in Brazil. J Wound Care. 2022 Nov 2;31(11):946–60.

He A, Ding X, Huang J, Luo X, Meng J, Cao Y, et al. [Clinical characteristics and risk factors of lower extremity arterial disease in patients with diabetic foot ulcer]. Nan Fang Yi Ke Da Xue Xue Bao. 2022 Apr 20;42(4):604–9.

Brennan MB, Powell WR, Kaiksow F, Kramer J, Liu Y, Kind AJH, et al. Association of Race, Ethnicity, and Rurality With Major Leg Amputation or Death Among Medicare Beneficiaries Hospitalized With Diabetic Foot Ulcers. JAMA Netw Open. 2022 Apr 21;5(4):e228399.

Ugwu E, Adeleye O, Gezawa I, Okpe I, Enamino M, Ezeani I. Predictors of lower extremity amputation in patients with diabetic foot ulcer: findings from MEDFUN, a multi-center observational study. J Foot Ankle Res. 2019 Dec 14;12(1):34.

Dra. Elaine Castañeira Jorge, Dra. Odalis Vázquez Díaz, Dr. C. Arístides Lázaro García Herrera, Dr. Ridel Febles Sanabria. Caracterización del riesgo de presentar pie diabético. Servicio Provincial de Angiología de Matanzas. 2014-2015. Rev Méd Electrón. 2018 Sep;40(5).

Piran N, Farhadian M, Soltanian AR, Borzouei S. Diabetic foot ulcers risk prediction in patients with type 2 diabetes using classifier based on associations rule mining. Sci Rep. 2024 Jan 5;14(1):635.

Skrepnek GH, Mills JL, Armstrong DG. A Diabetic Emergency One Million Feet Long: Disparities and Burdens of Illness among Diabetic Foot Ulcer Cases within Emergency Departments in the United States, 2006–2010. PLoS One. 2015 Aug 6;10(8):e0134914.

Cullen K, Jones M, Sheehan C, Game F, Vedhara K, Fitzsimmons D. Development of a resource-use measure to capture costs of diabetic foot ulcers to the United Kingdom National Health Service, patients and society. Journal of Research in Nursing. 2023 Dec 27;28(8):565–78.

Frescos N, Stopher L, Jansen S, Kaminski MR. The financial burden of diabetes-related foot disease in Australia: a systematic review. J Foot Ankle Res. 2023 Dec 27;16(1):92.

Rubio JA, Jiménez S, Álvarez J. Características clínicas y mortalidad de los pacientes atendidos en una Unidad Multidisciplinar de Pie Diabético. Endocrinol Diabetes Nutr. 2017 May;64(5):241–9.

Riaz M, Miyan Z, Zaidi SI, Alvi SF, Fawwad A, Ahmadani MY, et al. Characteristics of a large cohort of patients with diabetes having at?risk feet and outcomes in patients with foot ulceration referred to a tertiary care diabetes unit. Int Wound J. 2016 Oct 2;13(5):594–9.

Jin L, Xu W. Renal function as risk factor for diabetic foot ulcers: A meta?analysis. Int Wound J. 2023 Nov 22;

Gong HP, Ren Y, Zha PP, Li Y, Raju B, Gao Y, et al. [Clinical Characteristics of Diabetic Patients with Initial and Recurrent Foot Ulcers]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 Nov;53(6):969–75.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2024 Revista Colombiana de Endocrinología, Diabetes & Metabolismo

Dimensions


PlumX


Downloads

Download data is not yet available.