Resumen
Contexto: la influencia del contacto con disruptores endocrinos, tanto en el periodo prenatal como posnatal, ha generado preocupación, debido a su posible relación con el desarrollo de enfermedades endocrinológicas en la población pediátrica.
Objetivo: recopilar la evidencia científica con respecto a la presentación de enfermedades endocrinológicas en niños y adolescentes como consecuencia de la exposición a disruptores endocrinos.
Metodología: en esta revisión narrativa se examinó la literatura publicada sobre este tema mediante la utilización de bases de datos electrónicas y búsquedas manuales en revistas especializadas. En total se seleccionaron 33 artículos.
Resultados: se encontró relación entre el contacto con estas sustancias y el desarrollo de enfermedades no transmisibles, tales como obesidad, diabetes, síndrome metabólico, trastornos del crecimiento y desarrollo, y alteraciones en la función tiroidea. Asimismo, se ha comprobado que la exposición a dichos compuestos puede generar repercusiones a largo plazo en el desarrollo endocrino y reproductivo.
Conclusión: hay que realizar investigaciones adicionales para abordar las brechas en el conocimiento actual y establecer una base científica robusta que respalde la toma de decisiones en salud pública.
Citas
Gorini F, Bustaffa E, Coi A, Iervasi G, Bianchi F. Bisphenols as environmental triggers of thyroid dysfunction: clues and evidence. Int J Environ Res Public Health. 2020;17(8):2654. https://doi.org/10.3390/ijerph17082654
Stukenborg JB, Mitchell RT, Söder O. Endocrine disruptors and the male reproductive system. Best Pract Res Clin Endocrinol Metab. 2021;35(5):101567 https://doi.org/10.1016/j.beem.2021.101567
Kabir ER, Rahman MS, Rahman I. A review on endocrine disruptors and their possible impacts on human health. Environ Toxicol Pharmacol. 2015;40(1):241-58 https://doi.org/10.1016/j.etap.2015.06.009
La Merrill MA, Vandenberg LN, Smith MT, Goodson W, Browne P, Patisaul HB, et al. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nat Rev Endocrinol. 2020;16(1):45-57. https://doi.org/10.1038/s41574-019-0273-8
Anne B, Raphael R. Endocrine Disruptor Chemicals. En: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, et al., editores. Endotext [Internet]. South Dartmouth, Massachusetts, Estados Unidos: MDText.com, Inc.; 2000 [actualizado 2021 mzo. 16; citado 2023 may]. https://www.ncbi.nlm.nih.gov/books/NBK569327/
Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev. 2009;30(4):293-342. https://doi.org/10.1210/er.2009-0002
The Endocrine Disruption Exchange. Comprendiendo la disrupcio?n endocrina [Internet]. Colorado, Estados Unidos: TEDX; 2023 [citado 2023 my. 23]. https://endocrinedisruption.org/assets/media/documents/EDC%20Fact%20Sheet-Spanish%20Translation%2020180131.pdf
Predieri B, Iughetti L, Bernasconi S, Street ME. Endocrine disrupting chemicals’ effects in children: what we know and what we need to learn? Int J Mol Sci. 2022;23(19):11899. https://doi.org/10.3390/ijms231911899
Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR, Lee DH, et al. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev. 2012;33(3):378-455. https://doi.org/10.1210/er.2011-1050
Kiess W, Häussler G, Vogel M. Endocrine-disrupting chemicals and child health. Vol. 35, Best Pract Res Clin Endoc Metab. 2021;35(5):101516. https://doi.org/10.1016/j.beem.2021.101516
Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, et al. EDC-2: The Endocrine Society’s second scientific statement on endocrine-disrupting chemicals. Endocr Rev. 2015;36(6):E1-150. https://doi.org/10.1210/er.2015-1010
Perng W, Cantoral A, Soria-Contreras DC, Betanzos-Robledo L, Kordas K, Liu Y, et al. Exposición a químicos disruptores endócrinos obesogénicos y obesidad en niños y jóvenes de origen latino o hispano en Estados Unidos y Latinoamérica: una perspectiva del curso de la vida. Obes Rev. 2021;22(supl. 5):e13352. https://doi.org/10.1111/obr.13352
Pozo Román J, Márquez Rivera M, Muñoz Calvo MT. Pubertad precoz y retraso puberal. Adolescere. 2017;5(1):23-49. https://www.adolescenciasema.org/ficheros/REVISTA%20ADOLESCERE/vol5num1-2017/23-49%20Pubertad%20precoz%20y%20retraso%20puberal.pdf
De Angelis M, Schramm KW. Perinatal effects of persistent organic pollutants on thyroid hormone concentration in placenta and breastmilk. Mol Aspects Med. 2022;87:100988. https://doi.org/10.1016/j.mam.2021.100988
Kyriacou A, Tziaferi V, Toumba M. Stress, Thyroid dysregulation, and thyroid cancer in children and adolescents: proposed impending mechanisms. Horm Res Paediatr. 2023;96(1):44-53. https://doi.org/10.1159/000524477
Diamanti-Kandarakis E, Papalou O, Kandaraki E. Endocrine-disrupting chemicals and PCOS: A novel contributor in the etiology of the syndrome. En: Diamanti-Kandarakis E, editora. Polycystic ovary syndrome: challenging issues in the modern era of individualized medicine. Países Bajos: Elsevier; 2022. p. 227-44. https://doi.org/10.1016/B978-0-12-823045-9.00015-8
Saccardo Sarni RO, Kochi C, Suano-Souza FI. Childhood obesity: an ecological perspective. J Pediatr. 2022;98(supl. 1):S38-46. https://doi.org/10.1016/j.jped.2021.10.002
Sargis RM, Simmons RA. Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors. Diabetologia. 2019;62:1811-22. https://doi.org/10.1007/s00125-019-4940-z
Heras-González L, Espino D, Jimenez-Casquet MJ, Lopez-Moro A, Olea-Serrano F, Mariscal-Arcas M. Influence of BPA exposure, measured in saliva, on childhood weight. Front Endocrinol (Lausanne). 2022;13:1040583. https://doi.org/10.3389/fendo.2022.1040583
Predieri B, Bruzzi P, Bigi E, Ciancia S, Madeo SF, Lucaccioni L, et al. Endocrine disrupting chemicals and type 1 diabetes. Int J Mol Sci. 2020;21(8):2937. https://doi.org/10.3390/ijms21082937
Baldo F, Barbi E, Tornese G. Delayed pubarche. Ital J Pediatr. 2021;47(1):180. https://doi.org/10.1186/s13052-021-01134-0
Cargnelutti F, Di Nisio A, Pallotti F, Spaziani M, Tarsitano MG, Paoli D, et al. Risk factors on testicular function in adolescents. J Endocrinol Invest. 2022;45(9):1625-39. https://doi.org/10.1007/s40618-022-01769-8
Jung MK, Choi HS, Suh J, Kwon A, Chae HW, Lee WJ, et al. The analysis of endocrine disruptors in patients with central precocious puberty. BMC Pediatr. 2019;19(1):323. https://doi.org/10.1186/s12887-019-1703-4
Lopez-Rodriguez D, Franssen D, Heger S, Parent AS. Endocrine-disrupting chemicals and their effects on puberty. Best Pract Res Clin Endocrinol Metab. 2021;35(5):101579. https://doi.org/10.1016/j.beem.2021.101579
Encarnação T, Pais AA, Campos MG, Burrows HD. Endocrine disrupting chemicals: Impact on human health, wildlife and the environment. Sci Prog. 2019;102(1):3-42. https://doi.org/10.1177/0036850419826802
Ramsey JT, Li Y, Arao Y, Naidu A, Coons LA, Diaz A, et al. Lavender products associated with premature thelarche and prepubertal gynecomastia: case reports and endocrine-disrupting chemical activities. J Clin Endocrinol Metab. 2019;104(11):5393-405. https://doi.org/10.1210/jc.2018-01880
Ak?n L, Kendirci M, Narin F, Kurto?lu S, Hatipo?lu N, Elmal? F. Endocrine disruptors and polycystic ovary syndrome: Phthalates. J Clin Res Pediatr Endocrinol. 2020;12(4):393-400. https://doi.org/10.4274/jcrpe.galenos.2020.2020.0037
Luo Y, Nie Y, Tang L, Xu CC, Xu L. The correlation between UDP-glucuronosyltransferase polymorphisms and environmental endocrine disruptors levels in polycystic ovary syndrome patients. Medicine. 2020;99(11):e19444. https://doi.org/10.1097/MD.0000000000019444
Sakali AK, Bargiota A, Fatouros I, Jamurtas A, Macut D, Mastorakos G, et al. Effects on puberty of nutrition-mediated endocrine disruptors employed in agriculture. Nutrients. 2021;13(11):4184. https://doi.org/10.3390/nu13114184
Kumar M, Sarma DK, Shubham S, Kumawat M, Verma V, Prakash A, et al. Environmental endocrine-disrupting chemical exposure: role in non-communicable diseases. Front Public Health. 2020;8:553850. https://doi.org/10.3389/fpubh.2020.553850

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
Derechos de autor 2024 Revista Colombiana de Endocrinología, Diabetes & Metabolismo

