Experiencia en enfermedad de Cushing en el Hospital de San José: reporte de una serie de casos entre 2010 y 2023

pituitary gland
Cushing’s disease
hypercortisolism
pituitary adenoma
case series
adrenocorticotropic hormone
pituitary adrenocorticotropic hormone hypersecretion
neuroendocrine tumors

How to Cite

Tabares Rodríguez, S. C., & Rojas García , W. . (2026). Experience with Cushing’s disease at San José Hospital: A case series from 2010 to 2023. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 13(1). https://doi.org/10.53853/encr.13.1.959

Abstract

Introduction: Cushing's disease is a rare disorder characterized by pituitary overproduction of adrenocorticotropic hormone (ACTH), which leads to chronic and sustained exposure to endogenous corticosteroids.

Objective: The objective of this study was to characterize a series of Cushing's disease cases at San José Hospital in Bogotá.

Methodology: A descriptive study of patients with pituitary neuroendocrine tumors and associated Cushing's disease treated in the Endocrinology Department of San José Hospital (Bogotá, Colombia) between 2010 and 2023.

Results: A total of 12 cases of ACTH-producing pituitary tumors were identified. Eleven of these were women, with a mean age of 39.5 years at diagnosis. A total of 54.5% (n=6) of the cases were microadenomas, and the main documented symptoms were centripetal obesity (58.3%), violaceous striae (58.3%), and steroid acne (58.3%). All patients underwent surgery, and 7 (58%) required additional therapy for biochemical control, including reoperation (n = 3; 42%), radiotherapy (n = 4; 57%), somatostatin analogues (n = 5; 71%), and ketoconazole (n = 2; 28%).

Conclusions: The clinical and paraclinical presentation of this entity is similar among the different populations studied and the one in our study; however, the overall disease remission rate is relatively lower compared with that reported for the general international population.

https://doi.org/10.53853/encr.13.1.959

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Experience with Cushing's disease at San José Hospital: A case series from 2010 to 2023

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