Keywords
absorción de yodoradiactivo
estados radioactivos
estados radioactivos
How to Cite
Tovar Rojas, L. (2018). Absorción de Yodoradioactivo en los estados radioactivos. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, -2(1-2-3), 61–99. https://doi.org/10.53853/encr.-2.1-2-3.365
Abstract
Conclusiones
- Confirmamos la afirmación de Mc Girr y Hutchison de que hay una forma de cretinismo esporádico con absorción alta de yodo radioactivo por el tiroides.
- Se corrobora lo dicho por Lawson Wilkins, George Clayton y Morgan Berthrong, en el sentido de la buena respuesta a la terapéutica con hormona tiroidea en pacientes afectos de cretinismo esporádico. En los casos con bocio, este llegó a desaparecer por completo.
- Pienso que en cretinismo esporádico con absorción alta de yodo radioactivo por el tiroides hay carencia de tirosina para combinar el yodo elemento que la glándula ha captado de la sangre. Por lo tanto, el yodo elemento el cual es muy activo, se combinará con sustancias proteicas que no son tirosina y formará por lo tanto compuestos orgánicos de yodo que no llegan a completar el ciclo metabólico que conduce a la producción de tiroxina.
- Esta combinación de yodo elemento con una proteína que no es tirosina sería, a mi juicio, la responsable de que en algunos casos el radioyodo proteico en sangre presenta cifras altas y, sin embargo el organismo sufre las consecuencias de la carencia de hormona tiroidea.
- En el cretinismo esporádico la captación alta de yodo radioactivo por el tiroides, puede hacerse disminuir a niveles normales o subnormales por medio de la terapéutica con hormona tiroidea según lo que se deduce del estudio de mis casos.
- He observado que la disminución de la captación de radio-yodo por el tiroides es tanto mayor cuanto más elevada sea la administración de extractos tiroideos.
- A mi parecer, y según mis casos, en el cretinismo esporadico con captación alta de yodo radioactivo por el tiroides, el radioyodo proteico en sangre está en la mayor parte de los casos más acorde con el cuadro clínico de estos enfermos, que el estudio topográfico y las cifras globales de absorción del isótopó.
References
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2. BARON D. N.—Hypothyroidism and Diabetes Mellitus. The Lancet. 769. 1955.
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4. BEEK; KRONSBEIN and HOBBS.–Technical considerations in I 131 tracer studies. J. Clin Endoc. 16, 1.102. 1956.
5. BEATTIE and CHAMBERS—The anti-thyroid action of paraaminosalicylic acid. J. Endocr. 1953, 10, 65.
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11. ERNEST YOUNT and MAXWELL LITTLE.--Renal Clearence in patients wiht Myxedema.-J. Clin. Endoc. 1956, 115, 343.
12. FLOREZ TASCON.—Tiroides. 1957.
13. FERNANDEZ NOGUERA.—Bol. Inst. Patcl. Med. 1952, 151.
14. FOOTE and MACLAGAN,—The Thigh-neck clerance. A simplified ralioactive test of thyroid function. The Lancet 1951, 868.
15. GILSANZ.-Lecciones de Medicina Interna. 1956.
16. GOLBERT S. GORDAM.—Year bock of Endocrinology. 1953, 1954, Series.
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18. GANONG and HUME.-Effect of partial Hypophysectomy on adrenocortical, Thyroid and Gonalal Function in the dog. The Lancet, 1955, 389.
19. GABRIELSEN and KRETCHMER.–Salivary secretion of iodide. J. Clin. Endoc. 1956, 16, 1.347.
20. GREEN; WHITE; ENGELMAN and KRUPP.—Effecto of Butazolidin on I 131 uptake by the thyroid gland. Proc. Soe. Expl Biol (N. Y.) 1953. 82/0 (155).
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22. HYDOVITZ and ROSE.—Goiter and Myxedema following prolonged, ingestión of iodine. Report of case with unusual thyroid function. J. Clin. Endoc. 1956, 16, 1.109.
23. HUBBLE D.–Familial Cretinism. The Lancet 1953, 1113.
24. KEATING; HAINES: POWER; WILLIAMS.–The radio iodine-acumulating function of the human thyroid gland as diagnoste test in clinical medicine. J. Clin. Endoc. 1950, 10, 1425.
25. LI; RALL; Mac. LENA; LIPSETT; RAY; PEARSON.–Thyroid function following Hypophysectomy in man. J. Clin. Endoc. 1955, 15, 1228.
26. LE MARQUAND, HAUSMANN, HEMSTED.--Death in myxedema coma. Britisch Medical Journal, 1955, II, 173.
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32. MARAÑON y NOVAK.—Bol. Inst. Patol. Med. 1954, 106.
33. MARAÑON y ECHEVARRIA.—Bo!. Inst. Patol. Med. 1955, 90. 34. MARTINEZ DIAZ.—Bol. Patol. Med. 1947, 52.
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37. MORGANS; TROTTER.–Two cases of myxedema attributed of iodide administration. The Lancet 1953, 1335.
38. Mc GIRR and HUTCHISON.–Radioactive-iodine studies in nonendemic goitrous cretinism. The Lancet 1953, 1117.
39. MARCEL MOLDEN.—Hypothermic coma in Mixedema, Britsch Medical Journal 1955, II, 764.
40. MASON; OLIVER.–Urinary excretion of radioactive iodine as a diagnostic test. The Lancet 1949, 2, 456.
41. NORMAN SHARRER and SAMUEL ASPER—Inhibition of thyroidal radio-iodine uptake following intravenous administration of Thyroxine to normal and to Hypophysectomized adult subjects. J. Clin. Eadoc. 1956, 1311.
42. NORAH ELPHIASTONE.—Thiouracil in pregnancy its efeect on the foetus. The Lancet 1953, 1281.
43. NORBERT FREINKEL and SIDNEY INGBAR.–Concentration gradients for inorganic I 131 and chloride in myxedema human saliva. J. Clin. Investig. 1953, 32, 1077.
44. PEDRO-PONS y TAVERNA TORN.–Tratado de Patología y Clínica Médica. 1953.
45. PAWLAK-Bo!d. Inst. Patol. Med. 1954, 161.
46. PAUL STARR.—Diagnosis of hypothyroidism (PB I in diagnosis of hipothyroidism). The J. Clin. Endoc. 1953, 13, 1422.
47. ROSALIND PITT-RIVERS; STANBURY ard RAPP.-Conversión of thyroxine to 3-5-3' triiodothyronine in vivo. J. Clin. Endoc. 1955, 617.
48. RUSSELL FRASER and OLIVER GARROD --Primary myxedema apparently dating from post-partum shock. Britisch Medical Journa!, 1955, II, 1484.
49. REISS M. and HAIGH.–Various Forms of Hypothyroidism in mental disorder. Proceeding of the Roy. Soc. Med. 1954, 47, 889.
50. SANTIAGO PI SUNER.–Bioquímica, 1956.
51. STANBURY; KASSENAAR; MEIJER and TERPSTRA. -The occurrence of mono-and Di-iodotyrosine in the blood of a patient with congenital goiter. J. Clin. Endoc. 1955, 1216.
52. CHUMANN CHARLES.-Hypothyroidism due to thyrotropin deficiency without other manifestation of hypopituitarism. J Clin, Endoc. 1953, 13, 795.
53. STANBURY JOHN; KALEDVO OHELA and ROSALIND PITT-RIVERS. The Metabolism of iodine in a goitrous cretins compared with that in 2 patients receving methimazola, J. Clin. Endoc. 1955, 15. 54.
54. Sporadic cretinism with goitre. The Lancet 1955, 1328.
55. STANBURY and QUERIDO.-Genito and environmental factor in cretinism: a clasification. J. Clin. Edoc. 1956. 16, 1522.
56. TAYLOR and 'STEWART.-Distribution of Radis-iodine in Human Thyroid Gland. The Lancet 1951, 232.
57. TAYLOR.-Calcium a goitrogen. J. Clin. Endoc. 1954, 14, 1412.
58. THOMPSON; STURTEVANT; BIRDAND GLAZKO.-The effect of metabolites of chloramphenicol (chloromycetin) on the thyroid of the rat. "Endocrinology 1954, 55 (665).
59. TRUNNELL and WADE.-Cronologia del estudio de la síntesis de los compuestos yodados po medio del análisis cromatográfico. J. Clin. Endoc. 1955, 107, 117.
60. TROTTER W. R.-Effects of Triiodothyrcscetic acid as case of myxedema. The Lancet 1955, 374.
61. VELASQUEZ L.–Farmacologia. 1953.
62. WILKINS; CLAYTON and BERTHRONG.–Development of goiters in cretins iodine deficiency: hypothyroidism due to appatent inability of the thyroid gland to synthesize hormone. Endocrinology Excerpta Médica. 1955, 9, 287.
63. WILLIS SENSENBACH; LEONARD MADISON; SEYMOUR EISENBERG and LAMAR OCHS.–Cerebral circulation in Myxedema. Journal of Clin. Investigation. 1954, 1438.
64. WERNER.–Pituitary mixedema; case. J. Clin. Edoc. 1954, 14, 553
65. ZUZEK NOVAK.--Bol. Inst. Patel. Med. 1955, 29.
2. BARON D. N.—Hypothyroidism and Diabetes Mellitus. The Lancet. 769. 1955.
3. BLOM; TERPSTRA.—Higt PBI 131 concentration in blood of patients with myxedema: preliminary report. J. Clin. Endoc, 13, 989. 1953.
4. BEEK; KRONSBEIN and HOBBS.–Technical considerations in I 131 tracer studies. J. Clin Endoc. 16, 1.102. 1956.
5. BEATTIE and CHAMBERS—The anti-thyroid action of paraaminosalicylic acid. J. Endocr. 1953, 10, 65.
6. COSTA.-Thyroid function in crecins. The Lancet 202, 1953.
7. COULAUD.-Appearence of goitres in tb. patients trated and cured with PAS. Action of PAS on rats' thyroid. Rev. Tubero. 1954, 18 (261). Endocrinology Excerpta Medica, 1955. 9, 20). .
8. DUCOUDRE R.–Bsl. Inst. Patol. Mel. 1952, 170.
9. DUDLEY and MACLAGAN.—Myxedema from resorcinol ointmen:. The Lancet. 1951, 530.
10. DI GEORGE; D' ANGELO; PASHKIS.–Thyropituitary relations in cretinism and Hypothyroidism. The Lancet 1955, 389.
11. ERNEST YOUNT and MAXWELL LITTLE.--Renal Clearence in patients wiht Myxedema.-J. Clin. Endoc. 1956, 115, 343.
12. FLOREZ TASCON.—Tiroides. 1957.
13. FERNANDEZ NOGUERA.—Bol. Inst. Patcl. Med. 1952, 151.
14. FOOTE and MACLAGAN,—The Thigh-neck clerance. A simplified ralioactive test of thyroid function. The Lancet 1951, 868.
15. GILSANZ.-Lecciones de Medicina Interna. 1956.
16. GOLBERT S. GORDAM.—Year bock of Endocrinology. 1953, 1954, Series.
17. GILBERT S. GORDAM.–Year book Endocrinology. 1954, 1955 Series.
18. GANONG and HUME.-Effect of partial Hypophysectomy on adrenocortical, Thyroid and Gonalal Function in the dog. The Lancet, 1955, 389.
19. GABRIELSEN and KRETCHMER.–Salivary secretion of iodide. J. Clin. Endoc. 1956, 16, 1.347.
20. GREEN; WHITE; ENGELMAN and KRUPP.—Effecto of Butazolidin on I 131 uptake by the thyroid gland. Proc. Soe. Expl Biol (N. Y.) 1953. 82/0 (155).
21. HODGES ROBERT; EVANS; FITUS; BRADBURY and KEETEL. The accumulation of radioactivite iodine by human fetal thyroids. The J. Clin. Endoc. 1955, 115. 661.
22. HYDOVITZ and ROSE.—Goiter and Myxedema following prolonged, ingestión of iodine. Report of case with unusual thyroid function. J. Clin. Endoc. 1956, 16, 1.109.
23. HUBBLE D.–Familial Cretinism. The Lancet 1953, 1113.
24. KEATING; HAINES: POWER; WILLIAMS.–The radio iodine-acumulating function of the human thyroid gland as diagnoste test in clinical medicine. J. Clin. Endoc. 1950, 10, 1425.
25. LI; RALL; Mac. LENA; LIPSETT; RAY; PEARSON.–Thyroid function following Hypophysectomy in man. J. Clin. Endoc. 1955, 15, 1228.
26. LE MARQUAND, HAUSMANN, HEMSTED.--Death in myxedema coma. Britisch Medical Journal, 1955, II, 173.
27. MAC GAVACK, THOMAS HODGE.—The Thyroid, 1951.
28. MARAÑON.—Bol Inst. Patol. Med. 1949. 145.
29. MARAÑON.–Bol Inst. Patol. Med. 1950, 214.
30. MARANON.–Bcl. Inst. Patol. Med. 1951, 207.
31. MARAÑON, GIL y POROVNE.—Bol Inst. Patol. Mel, 1954, 269.
32. MARAÑON y NOVAK.—Bol. Inst. Patol. Med. 1954, 106.
33. MARAÑON y ECHEVARRIA.—Bo!. Inst. Patol. Med. 1955, 90. 34. MARTINEZ DIAZ.—Bol. Patol. Med. 1947, 52.
35. MORRIS DAVID-Transient Hypothyroidism in a newborn infant. The Lancet. 1953, 1284
36. Mc GIRR and HUTCHOSON.–Dysgenesis of the Thyroid Gland as a cause of cretinism and Juvenile Myxedema. The Journal Endo:. 1955, 5, 653.
37. MORGANS; TROTTER.–Two cases of myxedema attributed of iodide administration. The Lancet 1953, 1335.
38. Mc GIRR and HUTCHISON.–Radioactive-iodine studies in nonendemic goitrous cretinism. The Lancet 1953, 1117.
39. MARCEL MOLDEN.—Hypothermic coma in Mixedema, Britsch Medical Journal 1955, II, 764.
40. MASON; OLIVER.–Urinary excretion of radioactive iodine as a diagnostic test. The Lancet 1949, 2, 456.
41. NORMAN SHARRER and SAMUEL ASPER—Inhibition of thyroidal radio-iodine uptake following intravenous administration of Thyroxine to normal and to Hypophysectomized adult subjects. J. Clin. Eadoc. 1956, 1311.
42. NORAH ELPHIASTONE.—Thiouracil in pregnancy its efeect on the foetus. The Lancet 1953, 1281.
43. NORBERT FREINKEL and SIDNEY INGBAR.–Concentration gradients for inorganic I 131 and chloride in myxedema human saliva. J. Clin. Investig. 1953, 32, 1077.
44. PEDRO-PONS y TAVERNA TORN.–Tratado de Patología y Clínica Médica. 1953.
45. PAWLAK-Bo!d. Inst. Patol. Med. 1954, 161.
46. PAUL STARR.—Diagnosis of hypothyroidism (PB I in diagnosis of hipothyroidism). The J. Clin. Endoc. 1953, 13, 1422.
47. ROSALIND PITT-RIVERS; STANBURY ard RAPP.-Conversión of thyroxine to 3-5-3' triiodothyronine in vivo. J. Clin. Endoc. 1955, 617.
48. RUSSELL FRASER and OLIVER GARROD --Primary myxedema apparently dating from post-partum shock. Britisch Medical Journa!, 1955, II, 1484.
49. REISS M. and HAIGH.–Various Forms of Hypothyroidism in mental disorder. Proceeding of the Roy. Soc. Med. 1954, 47, 889.
50. SANTIAGO PI SUNER.–Bioquímica, 1956.
51. STANBURY; KASSENAAR; MEIJER and TERPSTRA. -The occurrence of mono-and Di-iodotyrosine in the blood of a patient with congenital goiter. J. Clin. Endoc. 1955, 1216.
52. CHUMANN CHARLES.-Hypothyroidism due to thyrotropin deficiency without other manifestation of hypopituitarism. J Clin, Endoc. 1953, 13, 795.
53. STANBURY JOHN; KALEDVO OHELA and ROSALIND PITT-RIVERS. The Metabolism of iodine in a goitrous cretins compared with that in 2 patients receving methimazola, J. Clin. Endoc. 1955, 15. 54.
54. Sporadic cretinism with goitre. The Lancet 1955, 1328.
55. STANBURY and QUERIDO.-Genito and environmental factor in cretinism: a clasification. J. Clin. Edoc. 1956. 16, 1522.
56. TAYLOR and 'STEWART.-Distribution of Radis-iodine in Human Thyroid Gland. The Lancet 1951, 232.
57. TAYLOR.-Calcium a goitrogen. J. Clin. Endoc. 1954, 14, 1412.
58. THOMPSON; STURTEVANT; BIRDAND GLAZKO.-The effect of metabolites of chloramphenicol (chloromycetin) on the thyroid of the rat. "Endocrinology 1954, 55 (665).
59. TRUNNELL and WADE.-Cronologia del estudio de la síntesis de los compuestos yodados po medio del análisis cromatográfico. J. Clin. Endoc. 1955, 107, 117.
60. TROTTER W. R.-Effects of Triiodothyrcscetic acid as case of myxedema. The Lancet 1955, 374.
61. VELASQUEZ L.–Farmacologia. 1953.
62. WILKINS; CLAYTON and BERTHRONG.–Development of goiters in cretins iodine deficiency: hypothyroidism due to appatent inability of the thyroid gland to synthesize hormone. Endocrinology Excerpta Médica. 1955, 9, 287.
63. WILLIS SENSENBACH; LEONARD MADISON; SEYMOUR EISENBERG and LAMAR OCHS.–Cerebral circulation in Myxedema. Journal of Clin. Investigation. 1954, 1438.
64. WERNER.–Pituitary mixedema; case. J. Clin. Edoc. 1954, 14, 553
65. ZUZEK NOVAK.--Bol. Inst. Patel. Med. 1955, 29.
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