Keywords
hypercortisolism
Cushing síndrome
Adrenal insufficiency
Glucocorticoids
How to Cite
Abstract
Objective: To determine salivary cortisol values in a small group of healthy schoolchildren and adolescents between the ages of 6-18 in the city of Medellín and determine their relationship with the circadian cycle according to the time of sampling.
Introduction: Salivary cortisol is an ultrafiltrate of plasma cortisol and reflects biologically active levels, this follows the circadian variation of serum cortisol, finding the highest levels in the morning and lower levels at midnight.
Methods: A descriptive observational study was carried out in which healthy schoolchildren and adolescents between 6 and 18 years of age were included. Two samples of saliva were collected in each child, the first at 8:00 a.m. and the second at 23:00 a.m. on the same day. The samples were processed by enzymatic immunoassay (EIA-ELISA) in Abad laboratory of the city of Medellín. The statistical method of Kolmogorov-Smirnov and Shapiro-Wilk was used to determine normality. For the presentation of results, the measures of central tendency and dispersion were used according to the normality of the variable.
Results: Data from 31 individuals were analyzed. 51.6 % of the population were men. The average age was 11.26 years (± 3.4) and the average BMI was 18.1 kg/m2 (± 2.8). With respect to cortisol levels, the cortisol level at 08:00 a.m. a median of 4.39 ng/ml was obtained (RIQ 2.76-6.98); and for the cortisol level at 11:00 p.m., a median of 0.51 ng/ml (RIQ 0.41-0.84) was obtained. There were no significant differences by sex.
Conclusion: The average salivary cortisol values in the group of healthy schoolchildren and adolescents in the city of Medellín are within the reference values reported in international studies, so it is recommended for the diagnosis and monitoring of hyper / hypocortisolism.
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