Palabras clave
yodo 131
tecnecio 99m
yodo radioactivo
tecnecio 99m
yodo radioactivo
Cómo citar
De León Usta, A., & Ahumada Barona, J. J. (2018). YODO 131 Y TECNECIO 99m en el estudio funcional y morfológico de Tiroides. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, -13(3), 125–135. https://doi.org/10.53853/encr.-13.3.159
Resumen
Fragmento
Las numerosas experiencias con el yodo radioactivo desde su introducción en 1938 para el estudio de la glandula tiroides (1) y su posterior empleo en el tratamiento de algunas afecciones de la misma (2), han dado a este radionúclido un sitio de reconocido privilegio en la medicina. Por la misma época del nacimiento de este, Perrier y Segre ( 3) obtuvieron por primera vez el elemento Tecnecio, mediante el bombardeo del Molibdeno con deuterones, dando a conocer sus características químicas dos años más tarde (4 ). Pero no fue sino 25 años despues cuando el Tecnecio 99m entró al campo médico al obtenerse facilmente de un generador (5). Su preeminente posición en la Medicina Nuclear en la actualidad, se debe a la facilidad de su obtención, a su ventajosa vida física media de seis horas, a su emisión gamma única de 140 kev, con la consiguiente baja radiación en los procedimientos diagnósticos a los pacientes, su facil detección y a la posibilidad de marcar diversos radiofármacos con relativa sencillez.
Citas
1. Hertz S. Roberts A, Evans RD; Radioactive iodine as an indicator in the study of thyroid physiology. Proc Soc Exp Biol Med.38:510,1938.
2. Hertz S, Roberts A: Application of radioactive iodine in therapy of Graves' disease. J Clin Invest 21:624, 1942.
3. Perrier C, Segré E : Radioactive isotopes of element 43. Nature 140:193,1937.
4. Perrier C, Segré E. Some Chemical properties of element 43. J Chem Phys 7: 155,1939.
5. Richards P: The Technetium 99m generator. En Radioactive Pharmaceuticals. (Andrews GA Kniseley RM, Wagner HN. eds). US Departament of Commerce. USAEC, Oak Ridge, Tenn: 1966. p 323-334.
6. Shambaugh GEIII, Quinn JL, Oyasu R, Freinkel N: Disparate thyroid imaging. Combined studies with sodium pertechnetate 99mTc and radioactive iodine. JAMA 228:866-869,1974.
7. Miller JM, Kasenter AG,Marks DS:Disparate imaging of the autonomous fuctiotioning thyroid nodule with 99m Pertechnetate and radioiodine. J Nucl Med 17:532-533, 1976.
8. Baumann EJ, Mertzger N: Behavior of the thyroid toward elements of the seventh periodic group. I Halogens and thiocyanate.Proc Soc Exp Biol Med 70:536. 1949.
9. Strauss HW.Herley PJ.Wagner HN: Advantages of 99mTc pertechnetate for thyroid scanning in patients with decreased radioiodine uptake. Radiology 97: 307-310.1970.
10. Keyes JW. Thrall JH. Carey JE: Technical considerations in In Vivo Thyroid studies. Sem Nucl Med 8:43-57,1978.
11. Berens SV, Long RF,Caplan GE: Thyroid 99mTc pertchnetate uptake: simple and accurate. Clin Nucl Med 1:148-149,1976.
12. Selby JB.Caldwell JG.Magoun SE, Beihn RM: The use of the 99mTc pertchnetate neck/thigh ratio as a test of thyroid function.Radiology 114:107-110,1975.
13. Selby JB.Buse MG, Goonerathe NS. Moore DO: The Anger camera and the pertechnetate ion in the routine evaluation of the thyroid uptake and imaging.Clin Nucl Med 4:233-237, 1979.
14. Sostre S,Parkih S:A visual index of thyroid function. Clin Nucl Med 4: 59,1979.
15. Otero-Ruiz E: Thyroid scintiscanning with radioiodine:experience in an endemic goiter region. J Nucl Med 7:343,1966.
16. Wahner HW, Cuello C. Aljure F: Bocio nodular y cancer de tiroides. Rev Soc Col Endrocrinol 5:85-87,1968.
17. Ahumada J. Gonzalez W, Velasquez I:Evaluación de la gammagrafia como metodo diagnóstico en patologia tiroidea. Rev Soc Col Endocrinol 9: 53-62,1973.
18. Villabona G. Mejia D. Ahumada J: Frecuencia del cancer en el nódulo "frio" único de tiroides. Rev lnst Nal Cancerol Col 1:129-140,1980.
19. Hurley JR. Becker DV: Thyroid suppresion and stimulation testing: the place of scanning in the evaluation of nodular thyroid disease. Sem Nucl Med 11:149-160, 1981.
20. Brooks JR ; The solitary thyroid nodule. Am J Surg 125 477.1973.
21. Nelson RL. Wahner HW,Gorman CA: Rectilinear thyroid scanning as a predictor of malignaney. Ann lnt Med 88:41-48.1978.
22. Tonami. N. Bunko H Michigishi T. Kuwajima A, Hisada K : Clinical application of 201 Tl scintigraphy in patients with cold thyroid nodules. Clin Nucl Med 3:217, 1978.
23. Steinberg M, Cavalieri RR . Choy SH: Uptake of technetium 99m pertechnetate in a primary thyroid carcinoma: need for caution in evaluating nodules. J Clin Endocrinol 31:81-84, 1970.
24. Usher MS. Arzoumanion AY: Thyroid nodule scans made woth pertechnetate and iodine may give unconsistent results J Nucl Med 12:136-137, 1971.
25. Hyrbayashi S. Koga Y, Kitahara T, Hishida T. Kiga M. lono S: lnconsistent images of thyroid nodules scintigrams made with iodone and pertechnetate: case report.J Nucl Med 16: 918, 1975.
26. Turner JW, Spencer RP: Thyroid carcinoma presenting as a pertechnetate "hot" nodule but without 131 I uptake: case report. J Nucl Med 17:22-23, 1976.
27. Massin JP. Planchon C, Pérez R : Comparison of 99mTc pertechnetate and 131 I in scanning of thyroid nodule. Clin Nucl Med 2:324-333, 1977.
28. Erjavec M. Movrin T. Auersberg M, Golough R : Comparative accumulation of 99mTc and 131 I on thyroid nodules: case report. J Nucl Med 18:346-347.1977.
29. Alderson PO, Summer HW, Siegel BA: The single palpable thyroid nodule. Evaluation by 99mTc pertechnetate imaging. Cancer 37:258-265, 1976.
30. McDougall IR, Kriss JP: Which radioisotope for diagnosis of thyroid disorders. Clin Nucl Med 1: 217-223. 1976.
31. Baum S: lmaging the nonfunctioning thyroid nodule. Clin Nucl Med 2:336-339, 1977
2. Hertz S, Roberts A: Application of radioactive iodine in therapy of Graves' disease. J Clin Invest 21:624, 1942.
3. Perrier C, Segré E : Radioactive isotopes of element 43. Nature 140:193,1937.
4. Perrier C, Segré E. Some Chemical properties of element 43. J Chem Phys 7: 155,1939.
5. Richards P: The Technetium 99m generator. En Radioactive Pharmaceuticals. (Andrews GA Kniseley RM, Wagner HN. eds). US Departament of Commerce. USAEC, Oak Ridge, Tenn: 1966. p 323-334.
6. Shambaugh GEIII, Quinn JL, Oyasu R, Freinkel N: Disparate thyroid imaging. Combined studies with sodium pertechnetate 99mTc and radioactive iodine. JAMA 228:866-869,1974.
7. Miller JM, Kasenter AG,Marks DS:Disparate imaging of the autonomous fuctiotioning thyroid nodule with 99m Pertechnetate and radioiodine. J Nucl Med 17:532-533, 1976.
8. Baumann EJ, Mertzger N: Behavior of the thyroid toward elements of the seventh periodic group. I Halogens and thiocyanate.Proc Soc Exp Biol Med 70:536. 1949.
9. Strauss HW.Herley PJ.Wagner HN: Advantages of 99mTc pertechnetate for thyroid scanning in patients with decreased radioiodine uptake. Radiology 97: 307-310.1970.
10. Keyes JW. Thrall JH. Carey JE: Technical considerations in In Vivo Thyroid studies. Sem Nucl Med 8:43-57,1978.
11. Berens SV, Long RF,Caplan GE: Thyroid 99mTc pertchnetate uptake: simple and accurate. Clin Nucl Med 1:148-149,1976.
12. Selby JB.Caldwell JG.Magoun SE, Beihn RM: The use of the 99mTc pertchnetate neck/thigh ratio as a test of thyroid function.Radiology 114:107-110,1975.
13. Selby JB.Buse MG, Goonerathe NS. Moore DO: The Anger camera and the pertechnetate ion in the routine evaluation of the thyroid uptake and imaging.Clin Nucl Med 4:233-237, 1979.
14. Sostre S,Parkih S:A visual index of thyroid function. Clin Nucl Med 4: 59,1979.
15. Otero-Ruiz E: Thyroid scintiscanning with radioiodine:experience in an endemic goiter region. J Nucl Med 7:343,1966.
16. Wahner HW, Cuello C. Aljure F: Bocio nodular y cancer de tiroides. Rev Soc Col Endrocrinol 5:85-87,1968.
17. Ahumada J. Gonzalez W, Velasquez I:Evaluación de la gammagrafia como metodo diagnóstico en patologia tiroidea. Rev Soc Col Endocrinol 9: 53-62,1973.
18. Villabona G. Mejia D. Ahumada J: Frecuencia del cancer en el nódulo "frio" único de tiroides. Rev lnst Nal Cancerol Col 1:129-140,1980.
19. Hurley JR. Becker DV: Thyroid suppresion and stimulation testing: the place of scanning in the evaluation of nodular thyroid disease. Sem Nucl Med 11:149-160, 1981.
20. Brooks JR ; The solitary thyroid nodule. Am J Surg 125 477.1973.
21. Nelson RL. Wahner HW,Gorman CA: Rectilinear thyroid scanning as a predictor of malignaney. Ann lnt Med 88:41-48.1978.
22. Tonami. N. Bunko H Michigishi T. Kuwajima A, Hisada K : Clinical application of 201 Tl scintigraphy in patients with cold thyroid nodules. Clin Nucl Med 3:217, 1978.
23. Steinberg M, Cavalieri RR . Choy SH: Uptake of technetium 99m pertechnetate in a primary thyroid carcinoma: need for caution in evaluating nodules. J Clin Endocrinol 31:81-84, 1970.
24. Usher MS. Arzoumanion AY: Thyroid nodule scans made woth pertechnetate and iodine may give unconsistent results J Nucl Med 12:136-137, 1971.
25. Hyrbayashi S. Koga Y, Kitahara T, Hishida T. Kiga M. lono S: lnconsistent images of thyroid nodules scintigrams made with iodone and pertechnetate: case report.J Nucl Med 16: 918, 1975.
26. Turner JW, Spencer RP: Thyroid carcinoma presenting as a pertechnetate "hot" nodule but without 131 I uptake: case report. J Nucl Med 17:22-23, 1976.
27. Massin JP. Planchon C, Pérez R : Comparison of 99mTc pertechnetate and 131 I in scanning of thyroid nodule. Clin Nucl Med 2:324-333, 1977.
28. Erjavec M. Movrin T. Auersberg M, Golough R : Comparative accumulation of 99mTc and 131 I on thyroid nodules: case report. J Nucl Med 18:346-347.1977.
29. Alderson PO, Summer HW, Siegel BA: The single palpable thyroid nodule. Evaluation by 99mTc pertechnetate imaging. Cancer 37:258-265, 1976.
30. McDougall IR, Kriss JP: Which radioisotope for diagnosis of thyroid disorders. Clin Nucl Med 1: 217-223. 1976.
31. Baum S: lmaging the nonfunctioning thyroid nodule. Clin Nucl Med 2:336-339, 1977
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