Palabras clave
Diabetes Mellitus Juvenil
Diabetes sacarina juvenil
insulina
Diabetes sacarina juvenil
insulina
Cómo citar
Fletcher, P. E., Trejos, J., & Luna, A. (2018). Problemática de la Diabetes Mellitus Juvenil. Revisión de 61 casos del Hospital General C.S.S. y del Hospital del Niño de Panamá. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, -11(1), 4–12. https://doi.org/10.53853/encr.-11.1.194
Resumen
Fragmento
Mientras no se pruebe lo contrario, en la Diabetes mellitus juvenil la herencia juega un papel primordial. Prevalece la opinión de que el factor hereditario sea un gene autosómico recesivo; pero otros piensan en la posibilidad de un gene multifactorial y algunos en un gene dominante. Otra causa capaz de producir diabetes en el niño sería la fibrosis quística; también procesos inflamatorios o granulomatosos y tumores.
La forma máis frecuente de diabetes sacarina juvenil, es aquella caracterizada por una falta de insulina casi absoluta, de aparición aguda, con la sintomatología clásica de la diabetes franca, con progreso en ocasiones hasta la ceto-acidosis. Desde 1960, Fajans informa sobre la diabetes juvenil química, latente y sub-clínica. También existe la pre-diabetes, con un retardo o disminución en la elevación de la insulinemia post estimulación pancreática, en el mellizo idéntico no diabético, en el hijo con dos padres diabéticos.
Citas
1. White P.; The child with diabetes. Med. Clin. N. Amer., 49: 1069-1079, 1965.
2. Simpson, N.E.: Multifactorial inheritance. A possible hypothesis for Diabetes. Diabetes, 462-471, 1964.
3. Harris H.: The familial distribution of diabetes mellitus: Study of relatives of 1, 241 diabetic propositi. Ann, Eugenics, 15: 95-119, 1950.
4. Hanwdwerger S., Roth J. Gorden P., Di Sant Agnese P., Carpenter D.F. and Peter G.: Glucose intolerance in cystic fibrosis, New Eng. J. Med. 281: 451-461, 1969.
5. Fajans, S.S., and Conn, J.W.: Tolbutamide induced improvement in carbohydrate tolerance of young people with mild diabetes mellitus. Diabetes, 9: 83-88, 1960.
6. Fajans, S.S., and Conn, J.W.: The use of tolbutamide in the treatment of young people with mild diabetes mellitus-A progress report. Diabetes, 11 (suppl.): 123-126, 1962.
7. Fajans, S.S. and Conn, J.W.: Prediabetes, subclinical diabetes and latent clinical diabetes: Interpretation, diagnosis and treatment. In leibel, B.S. and Wrenshall, G.S., eds.: On the Nature and treatment of diabetes. New Excerpta Medica Foundation, International Congress Series, 84, chap. 46, pp.641-656, 1965.
8. Fajans, S.S., Floyd, J.C., Jr. Conn, J.W., and Pek, S.: The course of asymptomatic diabetes of children, adolescents, and young adults. in Camerini-Davalos, R.A., and Cole, J.S., eds. Advances in Metabolic Disorders. Early Diabetes. New York, Academic Press, 1970, pp.377-384.
9. Fajans, S.S., Floyd, J.C., Jr. Pek, S. and Conn, J.W.: The course of asymptomatic diabetes in young people, as determined by levels of blood glucose and plasma insulin. Trans. Assoc. Amer. Phys, 82: 211-224, 1969.
10. Fajans, S.S. Floyd, J.C. Jr., Pek, s, and Conn, J.W. Studies on the natural history of asymptomatic diabetes in young people. Presented at the Panamerican Congress of Endocrinology, Aug. 17-21, 1970, sao Paulo, Brasil, Excerpta Medica, international Congress Series. (in press).
11. Fajans, S. et al. Studies on the Natural History of Asyntomatic Diabetes in young People. Metabolism, vol. 22, No. 2, 1973.
12. Jackson, R.L.: the definition of chemical Diabetes in Children. Metabolism, Vol. 22, No. 2, 1973
13. Cerasi, E., and Luft, R.: Insulin response to glucose infusion in diabetic and non-diabetic monozygotic twin pairs. Genetic Control of insulin Response? Acta. Endocrinol. 55: 330-345, 1967.
14. Siperstein, M.D., Unger, R.H. and Madison, L.L.: Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients. J. Clin. Invest., 47: 1973-1999, 1968.
15. Cornblath, M., and Schwartz, R.: Disorders of Carbohydrate Metabolism in Infancy. Philadelphia, W.B. Saunders, 1966, chap. 6.
16. Crain, A. J. Sussman, M.B., and Weil, W.B.Jr. family interaction, diabetes, and sibling relationship, internat. J. Social Pysichiat. 12; 35-43, 1966.
17. Swift, Ch. R.: Adjustment Problems in Juvenile Diabetes. Psychosomatic Medicine. Vol. XXIX, No. 6, 1967.
18. Camerini-Davalos, R. Marble, A. White, P. Belmonte, M. and Sargent, l: Effect of sulfonylurea compounds in diabetes children. New England J.Med. 256:817-1957.
19. Brush, J.M.: Initial stabilization of the diabetic child. A. J. Dis. Child.67: 429, 1944.
2. Simpson, N.E.: Multifactorial inheritance. A possible hypothesis for Diabetes. Diabetes, 462-471, 1964.
3. Harris H.: The familial distribution of diabetes mellitus: Study of relatives of 1, 241 diabetic propositi. Ann, Eugenics, 15: 95-119, 1950.
4. Hanwdwerger S., Roth J. Gorden P., Di Sant Agnese P., Carpenter D.F. and Peter G.: Glucose intolerance in cystic fibrosis, New Eng. J. Med. 281: 451-461, 1969.
5. Fajans, S.S., and Conn, J.W.: Tolbutamide induced improvement in carbohydrate tolerance of young people with mild diabetes mellitus. Diabetes, 9: 83-88, 1960.
6. Fajans, S.S., and Conn, J.W.: The use of tolbutamide in the treatment of young people with mild diabetes mellitus-A progress report. Diabetes, 11 (suppl.): 123-126, 1962.
7. Fajans, S.S. and Conn, J.W.: Prediabetes, subclinical diabetes and latent clinical diabetes: Interpretation, diagnosis and treatment. In leibel, B.S. and Wrenshall, G.S., eds.: On the Nature and treatment of diabetes. New Excerpta Medica Foundation, International Congress Series, 84, chap. 46, pp.641-656, 1965.
8. Fajans, S.S., Floyd, J.C., Jr. Conn, J.W., and Pek, S.: The course of asymptomatic diabetes of children, adolescents, and young adults. in Camerini-Davalos, R.A., and Cole, J.S., eds. Advances in Metabolic Disorders. Early Diabetes. New York, Academic Press, 1970, pp.377-384.
9. Fajans, S.S., Floyd, J.C., Jr. Pek, S. and Conn, J.W.: The course of asymptomatic diabetes in young people, as determined by levels of blood glucose and plasma insulin. Trans. Assoc. Amer. Phys, 82: 211-224, 1969.
10. Fajans, S.S. Floyd, J.C. Jr., Pek, s, and Conn, J.W. Studies on the natural history of asymptomatic diabetes in young people. Presented at the Panamerican Congress of Endocrinology, Aug. 17-21, 1970, sao Paulo, Brasil, Excerpta Medica, international Congress Series. (in press).
11. Fajans, S. et al. Studies on the Natural History of Asyntomatic Diabetes in young People. Metabolism, vol. 22, No. 2, 1973.
12. Jackson, R.L.: the definition of chemical Diabetes in Children. Metabolism, Vol. 22, No. 2, 1973
13. Cerasi, E., and Luft, R.: Insulin response to glucose infusion in diabetic and non-diabetic monozygotic twin pairs. Genetic Control of insulin Response? Acta. Endocrinol. 55: 330-345, 1967.
14. Siperstein, M.D., Unger, R.H. and Madison, L.L.: Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients. J. Clin. Invest., 47: 1973-1999, 1968.
15. Cornblath, M., and Schwartz, R.: Disorders of Carbohydrate Metabolism in Infancy. Philadelphia, W.B. Saunders, 1966, chap. 6.
16. Crain, A. J. Sussman, M.B., and Weil, W.B.Jr. family interaction, diabetes, and sibling relationship, internat. J. Social Pysichiat. 12; 35-43, 1966.
17. Swift, Ch. R.: Adjustment Problems in Juvenile Diabetes. Psychosomatic Medicine. Vol. XXIX, No. 6, 1967.
18. Camerini-Davalos, R. Marble, A. White, P. Belmonte, M. and Sargent, l: Effect of sulfonylurea compounds in diabetes children. New England J.Med. 256:817-1957.
19. Brush, J.M.: Initial stabilization of the diabetic child. A. J. Dis. Child.67: 429, 1944.
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