Palabras clave
Hipotálamo
hipófisis
tiroides
interrelaciones hipotálamo-hipófiso-tiroideas
hipófisis
tiroides
interrelaciones hipotálamo-hipófiso-tiroideas
Cómo citar
Otero-Ruiz, E. (2018). Hipotálamo, Hipófisis y Tiroides. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, -3(1), 53–65. https://doi.org/10.53853/encr.-3.1.347
Resumen
- Aún cuando existe mutua dependencia humoral (servomecanismo) entre hipófisis y tiroides, la capacidad de respuesta hipofisaria se halla presumiblemente regulada por el hipotálamo a través de un mediador humoral través de un mediador humoral de tipo nervioso o endocrino, de naturaleza no bien establecida hasta el presente.
- La hipófisis segrega una hormona tiroestimulante cuyo efecto principal es la aceleración del metabolismo de yodo por la glándula y que secundariamente produce aumento morfológico. La hormona es una glicoproteina caracterizable química (?) e inmunológicamente y dosificable por métodos biológicos. Estos últimos han permitido la identificación de un factor tiroestimulante "anormal" o "retardado" « en algunos casos de enfermedad de Basedow-Graves. El posible papel de la TSH, normal o anormal, en la etiología del hipertiroidismo, está todavía por aclararse.
Citas
1. ARON, M., VAN CAULERT, C. AND STAHL, S.: Comptes rendues Soc. Biol., Paris 107:64. 1931. Citado por Brown-Grant
(2).
2. BROWN-GRANT, K.: The "feed-back" hypothesis of the control of thyroid function. Ciba Found. Coll. on Endocrinology, Vol. 10, 1957. Pp. 97-116.
3. GREER, M.A.: The influence of the central nervous system on the Control of thyrotropin secretion. Ciba Foun. Coll. on Endocrinology Vol. 10, 1957. Pp. 34-47.
4. BROWN-GRANT, K.: The hypothalamus and the thyroid gland. Brit. Med. Bull. 16:165-169 (May) 1960.
5. WOLFF, J. AND GOLDBERG, R.C.: Disoders of iodine metabolism. En Thompson, R. H. ANI) KING, E. J.: Biochemical disorders in human disease. Academic Press, N. Y. 1957.
Pp. 289-351.
6. HARRIS, G. W.: Neural control of the pituitary gland. Arnold
Publ. London, 1955.
7. McCULLAGH, E. P., CLAMEN, M. GARDNER, W., J., KENNE
DY, R. J. AND LOCKHART, G.: Exophtalmos of Graves' disease: a summary of the present status of therapy. Ann. Int. Med. 48:445-470 (March) 1958.
8. NIKITOVICH-WINER, M. AND EVERETT, J.: Functional restitution of pituitary grafts retransplanted from kidney to median eminence. Endocrinology 63:916-930 (Dec.) 1958.
9. NIKITOVICH-WINER, M. AND EVERETT, J.: Histocytologic
changes in grafts of rat pituitary on the kidney and upon retransplantation under the diencephalon. Endocrinology 65:
357-368 (Sept.) 1959.
10. GREER. M. A.: The role of the hypothalamus in the control of thyroid function. J. Clin. Endocr. & Metab. 12:1259-1268 (Oct.) 1952.
11. HALMI. N. S. SPIRTOS, B. N., BOGDANOVE, E. M. AND LIP
NER, H. L.: Endocrinology 52:19-27, 1953. Citado por Bogdanove (12).
12. BOGDANOVE, E. M.. SPIRTOS, B. N. AND HALMI, N. S.: Further observations on pituitary structure and function in rats bearing hypotalamic lesions. Endocrinology 57:302-315
(Sept.) 1955.
13. BOGDANOVE, EE.M. AND BOGDANOVE, J. N.: Thyroid weight, microscopic structure and radioiodine concentration at various levels of thyrotropin secretion in the goitrogen-treated rat. Endocrinology 61:52-58 (July) 1957.
14. D'ANGELO, S.A. AND TRAUM, R.: Pituitary-thyroid function in rats with hypothalamic lesions. Endocrinology 59:593-595
(Nov.) 1956.
15. BOGDANOVE, F. M. AND D' ANGELO, S. A.: The effec of hypothalamic lesions on goitrogenesis and pituitary TSH secretion in the propyl-thiouracil treated guinea-pig. Endocrinology 6-1:53-61 (Jan.) 1959.
16. GREER., M. A.: Comunicación personal. (11th. Post-Grad. Assembly in Endocrinology and Meabolism, Endocrine Society,
San Francisco, Nov. 1959).
17. GREER, M. A.: Correlation of radioiodine uptake with thyroid weight in the mouse at various levels of exogenous and endogenous thyrotropin stimulation. Endocrinology 64: 724-729 (May) 1959.
18. FLORSHEIM, W. H.: The effec of anterior hypothalmic lesions on thyroid function and goiter development in the rat. Endocrinology 62:783-789 (June) 1958.
19. FLORSHEIM, W. H.: influence of hypothalamus on pituitary-thyroid axis in the rai. Proc. Soc. Exp. Biol. & Med. 100:73 (Jan.) 1959.
20. HARRIS, G. W. AND WOODS, J. W : Hypothalamus-pituitary
thyroic relationships. Ciba. Found. Coll. on Endocrinology.
Vol. 10, 1957. Pp. 3-20.
21. ANDERSON, E., BATES. R. W.. HAWTHORNE, E., HAYMAKER, W. KNOWLTON, K., RIOCI, D, SPENCE w. T. WILSON, H.: The efects of midbrain and spinal cord transection on endocrine and metabolic function with postulation of a midorain hypothalamico pituitary activating system. Recent
Progr. Hormone Res. Acad. Press, N. Y. 1957. Pp. 21-59.
22. FORD, D. 1. AND GROSS, J.: The localization of 1-131 labeled triiodothyronine and thyroxine in the pituitary and brain of the male guinea-pig. Endocrinology 63:549-555 (Nov.) 1958.
23. FORD, D. II., KANTOUNIS, S AND LAWRENCE, R.: The localization of I-131 labeled triidothyronine in the pituitary and brain of normal and thyroidectomized male rats. Endocrinology 64:977-991 (June) 1959.
24. YAMADA, T, AND GREER, M. A.: Studies on the mechanism of hypothalamic control of thyrotropin secretion effect of thyroxine injection into the hypothalamus or the pituitary on thyroid iiormone release. Endocrinology 64.559-556 (April)
1959.
25. GREER. N. A.. YAMADA, T. AND JINO, S.: The participation of the central nervous system in the control of thyroid function Ann. N. Y. Acad. of Sciences Sti: 667-675 (April) 1960.
26. ROSE, S., NELSON, J. AND BRADLEY. 1. R.: Regulation of TSH release. Ann. N.Y. Acad. of Sciences 86:647-656 (April)
1960.
27. CROWN, J., LABELLA, F. AND ULVEDAL, F.: Studies on the
intracellular localization of anterior pituitary hormones by means of differential centrifugation, Endocrinology 66:1-12
(Jan.) 1960.
28. PURVES, TH. D. AND GRIESBACH, W. E.: Pituitary cytology in on Endocrinology Vol. 10. 1937. Pp. 51-58.
29. FURTH, J., DENT', J. BURNETT', W. AND GADSDEN, E.: The
mechanism of induction and the characteristics of pituitary tumors induced by thyroidectomy. J. Clin. Endocr. & Me:
tab. 15:81-97 (Jan.) 1953.
30. DENT, J., GADSDEN, E AND FURTH, J.: On the relation bet
ween thyroid depression and pituitary tumor inäuction in
mice. Cancer Research 15:70-75 (Jan.) 1955.
31. DENT, J., GADSDEN, E. AND FURTII, J.: Further studies on induction and growth of thyrotropic pituitary tumors in mice.
Cancer Res 16:171-174 (Feb.) 1956.
32. FURTH, J. AND CLIFTON, K. II.: Experimental pituitary tumors and the role of pituitary hormones in tumorigenesis of the breast and thyroid Cancer 10:842-853 (Jul-Aug.) 1957.
33. RAWSON, R, W. AND MONEY, W. L.: Comunicación personal (11 th. Post- Grad Assembly in Endocrinology and Metabolism, Endocrine Soc. San Francisco, No. 1959).
33a. MONEY, W. L., KUMAOKA, S., RAWSON, R. W. AND KROC,
R. L : Comparative effects of thyroxine analogues in experimental animals. Ann4 N. Y. Acad. of Sciencies 86:512-544 (Aprii) 1960
34. PIERCE, J, G., CARSTEN, M. E. AND WYNSTON, L. K.: Purification and chemistry of the thyroid stimulating hormone. Ann. N.Y. Acad. of Sciencies 86:612-624 (April) 1960. 35. PURVES, H. D. AND ADAMS, D.D.: Thyroid-stimulating hormone. Brit. Med. Bull. 16:128-132 (May) 1960.
36. WERNER, S. C., OTERO-RUIZ, E., BATES, R. W. AND SIEGEL.
B.: Neutralization of human serum pituitary thyrotropic fractions with antiesra to bovine pituitary Thyrotropin. Nature 185: 472-473 (Feb) 1960.
37. CLINE. M. J., SELENKO0, H. A. AND BOOKE, M. S.: Inhibition of thyrotropic activity by inniunologically specific an
tiserum. Endocrinology 67:273-276 (Aug.) 1960
38. HALMI. N. S.: Factors influencing the thyroidal iodine pump. Ciba Found. Coll. on Endocrinology. Vol 10, 1957. Pp. 79-96.
39. SONENBERG, M. AND MONEY, W. L.: Chemical derivatives of thyroid stimulating hormone preparations. Ann. N.Y. Acad.
of Sciences 86:625-646 (April) 1960.
40. SMITH, P.E. AND SMITII, L.P.: J. Med. Research 43:267, 1922. Citado por Purves & Adams (35).
41. BROWN, J. R.: The measurement of thyroid-stimulating hormone (TSH) in body bluids: a critical review. Acta Endocrinologica 32:289-309, 1959.
42. BAKKE. J. ... HEIDEMANN, L... LAWRENCE, N. AND WIDERG,
C. Endocrinology G1:252, 1957.
41b. D'ANGELO, S. A, AND GORDON, A. S. Endrocrinology 46-39, 1950.
41c. HENRY, 1:. AND BLOCITE-MICHEL. 1.: Ann. Endocr. Paris 16:258, 1955.
41d. QUERIDO, A., KASSENAAR. A. II. AND LAMEIJER, L.D.: Acta
Endo. Copenhagen 12:335. 1953.
41e. KRISS. J.P. AND GREENSPAN, F.S.: J. Clin. Endocr. & Me.
tab. 14:770, 1951.
41f. GILLILAND, IC. AND STRUDWICK, J.!.: Clin Science. 12:265 1953.
41g. ADAMS, D.D. AND PURVES, U. D: Endocrinology 57:17, 1955.
41h. McKENZIE, J.M.: Fderations Proceedings 16:17, 1957.
42. GREER. M.A. AND SHULL. II. T.: A quantitative study of the
effect of thyrotropin upon the thyroidal secretion rate in euthyroid and thyrotoxic subjects. J. Clin. Endocr. & Me
tab 07:1030-1099 (Sept.) 1957.
43. ADAMS, D.D.: The presence of an abnormal TSH in the serum of some thyrotoxic patients. J. Clin. Endocr. & Metab. 18:699 712 (July) 1958.
44. MCKENZIE, J. M.: Delaved thyroid response to serum from thyro-toxic patients. Endocrinology 62:863-868 (June) 1958.
45. ADAMS, D.D.. PURVES, II.D. AND SIRETT. N. E.. The response of hypophysectomized mice to injection of human serum ( thyroic stimulator. Endocrinology 68:154-155 (Jan.) 1961.
46. DOBYNS. B. M. AND WILSON, L.A.: An exophalamos-producing substance in the serum of patients suffering from progressive exophtalmos. J. Clin. Endocr. & Metab. 14:1392-1102 (Nov.) 1954.
47. WERNER. S.C.. HAMILTON. JI. AND NEMETIT, N.: Graves'disease: Hyperthyroidism or hyperpituitarism? J. Clin. Endocr. & Metab. 12:1561-1571 (Dec.) 1952.
48. A.W.G. Effect of thyrotropic hormone on the accumulation of radioative iodine in thyrotoxicosis. J. Clin. En
docr. & Metab. 19:1252-1257 (Oct.) 1959.
49. WERNER. S.C AND WELLINGTON, S.: Hyperthyroidism in a
patient with a pituitary chromophobe adenoma and a fragment of normal pituitary. J. Clin. Endocr. & Metab. 18:266-270 (March) 1958.
50. FAJANS, S: Hyperthyroidism in a a patient with post-partum necrosis of the pituitary: case report and implication. J. Clin. Endocr. & Metab. 18:271-277 (March) 1958.
(2).
2. BROWN-GRANT, K.: The "feed-back" hypothesis of the control of thyroid function. Ciba Found. Coll. on Endocrinology, Vol. 10, 1957. Pp. 97-116.
3. GREER, M.A.: The influence of the central nervous system on the Control of thyrotropin secretion. Ciba Foun. Coll. on Endocrinology Vol. 10, 1957. Pp. 34-47.
4. BROWN-GRANT, K.: The hypothalamus and the thyroid gland. Brit. Med. Bull. 16:165-169 (May) 1960.
5. WOLFF, J. AND GOLDBERG, R.C.: Disoders of iodine metabolism. En Thompson, R. H. ANI) KING, E. J.: Biochemical disorders in human disease. Academic Press, N. Y. 1957.
Pp. 289-351.
6. HARRIS, G. W.: Neural control of the pituitary gland. Arnold
Publ. London, 1955.
7. McCULLAGH, E. P., CLAMEN, M. GARDNER, W., J., KENNE
DY, R. J. AND LOCKHART, G.: Exophtalmos of Graves' disease: a summary of the present status of therapy. Ann. Int. Med. 48:445-470 (March) 1958.
8. NIKITOVICH-WINER, M. AND EVERETT, J.: Functional restitution of pituitary grafts retransplanted from kidney to median eminence. Endocrinology 63:916-930 (Dec.) 1958.
9. NIKITOVICH-WINER, M. AND EVERETT, J.: Histocytologic
changes in grafts of rat pituitary on the kidney and upon retransplantation under the diencephalon. Endocrinology 65:
357-368 (Sept.) 1959.
10. GREER. M. A.: The role of the hypothalamus in the control of thyroid function. J. Clin. Endocr. & Metab. 12:1259-1268 (Oct.) 1952.
11. HALMI. N. S. SPIRTOS, B. N., BOGDANOVE, E. M. AND LIP
NER, H. L.: Endocrinology 52:19-27, 1953. Citado por Bogdanove (12).
12. BOGDANOVE, E. M.. SPIRTOS, B. N. AND HALMI, N. S.: Further observations on pituitary structure and function in rats bearing hypotalamic lesions. Endocrinology 57:302-315
(Sept.) 1955.
13. BOGDANOVE, EE.M. AND BOGDANOVE, J. N.: Thyroid weight, microscopic structure and radioiodine concentration at various levels of thyrotropin secretion in the goitrogen-treated rat. Endocrinology 61:52-58 (July) 1957.
14. D'ANGELO, S.A. AND TRAUM, R.: Pituitary-thyroid function in rats with hypothalamic lesions. Endocrinology 59:593-595
(Nov.) 1956.
15. BOGDANOVE, F. M. AND D' ANGELO, S. A.: The effec of hypothalamic lesions on goitrogenesis and pituitary TSH secretion in the propyl-thiouracil treated guinea-pig. Endocrinology 6-1:53-61 (Jan.) 1959.
16. GREER., M. A.: Comunicación personal. (11th. Post-Grad. Assembly in Endocrinology and Meabolism, Endocrine Society,
San Francisco, Nov. 1959).
17. GREER, M. A.: Correlation of radioiodine uptake with thyroid weight in the mouse at various levels of exogenous and endogenous thyrotropin stimulation. Endocrinology 64: 724-729 (May) 1959.
18. FLORSHEIM, W. H.: The effec of anterior hypothalmic lesions on thyroid function and goiter development in the rat. Endocrinology 62:783-789 (June) 1958.
19. FLORSHEIM, W. H.: influence of hypothalamus on pituitary-thyroid axis in the rai. Proc. Soc. Exp. Biol. & Med. 100:73 (Jan.) 1959.
20. HARRIS, G. W. AND WOODS, J. W : Hypothalamus-pituitary
thyroic relationships. Ciba. Found. Coll. on Endocrinology.
Vol. 10, 1957. Pp. 3-20.
21. ANDERSON, E., BATES. R. W.. HAWTHORNE, E., HAYMAKER, W. KNOWLTON, K., RIOCI, D, SPENCE w. T. WILSON, H.: The efects of midbrain and spinal cord transection on endocrine and metabolic function with postulation of a midorain hypothalamico pituitary activating system. Recent
Progr. Hormone Res. Acad. Press, N. Y. 1957. Pp. 21-59.
22. FORD, D. 1. AND GROSS, J.: The localization of 1-131 labeled triiodothyronine and thyroxine in the pituitary and brain of the male guinea-pig. Endocrinology 63:549-555 (Nov.) 1958.
23. FORD, D. II., KANTOUNIS, S AND LAWRENCE, R.: The localization of I-131 labeled triidothyronine in the pituitary and brain of normal and thyroidectomized male rats. Endocrinology 64:977-991 (June) 1959.
24. YAMADA, T, AND GREER, M. A.: Studies on the mechanism of hypothalamic control of thyrotropin secretion effect of thyroxine injection into the hypothalamus or the pituitary on thyroid iiormone release. Endocrinology 64.559-556 (April)
1959.
25. GREER. N. A.. YAMADA, T. AND JINO, S.: The participation of the central nervous system in the control of thyroid function Ann. N. Y. Acad. of Sciences Sti: 667-675 (April) 1960.
26. ROSE, S., NELSON, J. AND BRADLEY. 1. R.: Regulation of TSH release. Ann. N.Y. Acad. of Sciences 86:647-656 (April)
1960.
27. CROWN, J., LABELLA, F. AND ULVEDAL, F.: Studies on the
intracellular localization of anterior pituitary hormones by means of differential centrifugation, Endocrinology 66:1-12
(Jan.) 1960.
28. PURVES, TH. D. AND GRIESBACH, W. E.: Pituitary cytology in on Endocrinology Vol. 10. 1937. Pp. 51-58.
29. FURTH, J., DENT', J. BURNETT', W. AND GADSDEN, E.: The
mechanism of induction and the characteristics of pituitary tumors induced by thyroidectomy. J. Clin. Endocr. & Me:
tab. 15:81-97 (Jan.) 1953.
30. DENT, J., GADSDEN, E AND FURTH, J.: On the relation bet
ween thyroid depression and pituitary tumor inäuction in
mice. Cancer Research 15:70-75 (Jan.) 1955.
31. DENT, J., GADSDEN, E. AND FURTII, J.: Further studies on induction and growth of thyrotropic pituitary tumors in mice.
Cancer Res 16:171-174 (Feb.) 1956.
32. FURTH, J. AND CLIFTON, K. II.: Experimental pituitary tumors and the role of pituitary hormones in tumorigenesis of the breast and thyroid Cancer 10:842-853 (Jul-Aug.) 1957.
33. RAWSON, R, W. AND MONEY, W. L.: Comunicación personal (11 th. Post- Grad Assembly in Endocrinology and Metabolism, Endocrine Soc. San Francisco, No. 1959).
33a. MONEY, W. L., KUMAOKA, S., RAWSON, R. W. AND KROC,
R. L : Comparative effects of thyroxine analogues in experimental animals. Ann4 N. Y. Acad. of Sciencies 86:512-544 (Aprii) 1960
34. PIERCE, J, G., CARSTEN, M. E. AND WYNSTON, L. K.: Purification and chemistry of the thyroid stimulating hormone. Ann. N.Y. Acad. of Sciencies 86:612-624 (April) 1960. 35. PURVES, H. D. AND ADAMS, D.D.: Thyroid-stimulating hormone. Brit. Med. Bull. 16:128-132 (May) 1960.
36. WERNER, S. C., OTERO-RUIZ, E., BATES, R. W. AND SIEGEL.
B.: Neutralization of human serum pituitary thyrotropic fractions with antiesra to bovine pituitary Thyrotropin. Nature 185: 472-473 (Feb) 1960.
37. CLINE. M. J., SELENKO0, H. A. AND BOOKE, M. S.: Inhibition of thyrotropic activity by inniunologically specific an
tiserum. Endocrinology 67:273-276 (Aug.) 1960
38. HALMI. N. S.: Factors influencing the thyroidal iodine pump. Ciba Found. Coll. on Endocrinology. Vol 10, 1957. Pp. 79-96.
39. SONENBERG, M. AND MONEY, W. L.: Chemical derivatives of thyroid stimulating hormone preparations. Ann. N.Y. Acad.
of Sciences 86:625-646 (April) 1960.
40. SMITH, P.E. AND SMITII, L.P.: J. Med. Research 43:267, 1922. Citado por Purves & Adams (35).
41. BROWN, J. R.: The measurement of thyroid-stimulating hormone (TSH) in body bluids: a critical review. Acta Endocrinologica 32:289-309, 1959.
42. BAKKE. J. ... HEIDEMANN, L... LAWRENCE, N. AND WIDERG,
C. Endocrinology G1:252, 1957.
41b. D'ANGELO, S. A, AND GORDON, A. S. Endrocrinology 46-39, 1950.
41c. HENRY, 1:. AND BLOCITE-MICHEL. 1.: Ann. Endocr. Paris 16:258, 1955.
41d. QUERIDO, A., KASSENAAR. A. II. AND LAMEIJER, L.D.: Acta
Endo. Copenhagen 12:335. 1953.
41e. KRISS. J.P. AND GREENSPAN, F.S.: J. Clin. Endocr. & Me.
tab. 14:770, 1951.
41f. GILLILAND, IC. AND STRUDWICK, J.!.: Clin Science. 12:265 1953.
41g. ADAMS, D.D. AND PURVES, U. D: Endocrinology 57:17, 1955.
41h. McKENZIE, J.M.: Fderations Proceedings 16:17, 1957.
42. GREER. M.A. AND SHULL. II. T.: A quantitative study of the
effect of thyrotropin upon the thyroidal secretion rate in euthyroid and thyrotoxic subjects. J. Clin. Endocr. & Me
tab 07:1030-1099 (Sept.) 1957.
43. ADAMS, D.D.: The presence of an abnormal TSH in the serum of some thyrotoxic patients. J. Clin. Endocr. & Metab. 18:699 712 (July) 1958.
44. MCKENZIE, J. M.: Delaved thyroid response to serum from thyro-toxic patients. Endocrinology 62:863-868 (June) 1958.
45. ADAMS, D.D.. PURVES, II.D. AND SIRETT. N. E.. The response of hypophysectomized mice to injection of human serum ( thyroic stimulator. Endocrinology 68:154-155 (Jan.) 1961.
46. DOBYNS. B. M. AND WILSON, L.A.: An exophalamos-producing substance in the serum of patients suffering from progressive exophtalmos. J. Clin. Endocr. & Metab. 14:1392-1102 (Nov.) 1954.
47. WERNER. S.C.. HAMILTON. JI. AND NEMETIT, N.: Graves'disease: Hyperthyroidism or hyperpituitarism? J. Clin. Endocr. & Metab. 12:1561-1571 (Dec.) 1952.
48. A.W.G. Effect of thyrotropic hormone on the accumulation of radioative iodine in thyrotoxicosis. J. Clin. En
docr. & Metab. 19:1252-1257 (Oct.) 1959.
49. WERNER. S.C AND WELLINGTON, S.: Hyperthyroidism in a
patient with a pituitary chromophobe adenoma and a fragment of normal pituitary. J. Clin. Endocr. & Metab. 18:266-270 (March) 1958.
50. FAJANS, S: Hyperthyroidism in a a patient with post-partum necrosis of the pituitary: case report and implication. J. Clin. Endocr. & Metab. 18:271-277 (March) 1958.
Los autores deben declarar revisión, validación y aprobación para publicación del manuscrito, además de la cesión de los derechos de publicación, mediante un documento que debe ser enviado antes de la aparición del escrito. Puede consultar una copia del documento aquí