Hormonal and biochemical variables of bone mineral density and its correlation with young men obese and young men lean not-diabetic
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Keywords

obesity
bone density
densitometry

How to Cite

Romero, M. C., Sierra, S. F., Rincón, J. D., Martínez, L. A., Pulido, J. C., Maldonado, L. M., Franco, R., Arteaga, J. M., Alzate, J. P., & Camino, J. E. (2019). Hormonal and biochemical variables of bone mineral density and its correlation with young men obese and young men lean not-diabetic. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 6(3), 178–186. https://doi.org/10.53853/encr.6.3.532

Abstract

Introduction: Obesity has been associated with increased bone mineral density (BMD); however, recent studies report that it may lead to an increase in resorption and the risk of fracture.
Materials and methods: Analytical cross-sectional study that included men between 18 and 30 years old, in whom various hormonal measurements were taken (insulin, free and total testosterone, IGF-1, estradiol, leptin and adiponectin), biochemistry (PTOG-glucose, total cholesterol, HDL-C, LDL-C, RCP and HOMA-IR), anthropometric and others as body fat composition, BMD and bone mineral composition. The differences of the quantitative variables between obese and non-obese were evaluated by means of a T-student test or Wilcoxon test. To evaluate the correlation of BMD with the other variables, the Spearman correlation was used. Finally, a linear regression model is performed to predict BMD.
Results: This study included 34 obese and 35 non-obese individuals. In the non-obese group, an average of 1159 g (+/-0.08 g/cm2 ) of BMD was obtained compared to the group of obese men, with a mean of 1.311 g (+/-0.1 g/cm2 ) p = 0.001. It was found that BMD has a strong correlation with bone mineral content in the non-obese and moderate in the obese group. Adiponectin was negatively and moderately correlated in the obese group and weakly in the non-obese group. Finally, it was found that the presence of obesity, total fat, bone mineral content, basal insulin and HOMA-IR, significantly predict BMD in a linear regression model.
Conclusion: Both, BMD and bone mineral, content are higher in obese individuals compared to non-obese individuals, body mass index and variables such as insulin predict bone mineral density.

https://doi.org/10.53853/encr.6.3.532
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