Palabras clave
insulina
Frederick Banting
Charles Best
James Rickard Macleod
Frederick Banting
Charles Best
James Rickard Macleod
Cómo citar
Jácome, A. (2020). El descubrimiento de la insulina. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 7(2), 133–138. https://doi.org/10.53853/encr.7.2.614
Resumen
La insulina fue descubierta en Toronto en el verano de 1921. Los gestores del descubrimiento fueron Banting y Best, quienes permanecieron encerrados en aquellos calurosos meses haciendo experimentos en perros. Tanto estos dos investigadores como McLeod, quien era el profesor y jefe de Fisiología en Toronto, y Collip, quién enderezó las investigaciones hacia un producto más puro, reclamaron también su derecho. Zuelzer, en Alemania, Paulesco, en Rumania, y Scott, en Estados Unidos, lo hicieron igual y con anterioridad. Todos estos fueron rescatados por los historiadores en décadas posteriores, pero el premio Nobel lo ganaron Banting y McLeod, y con ellos perdurará el recuerdo.
Citas
1. Bliss M. The discovery of insulin. Chicago: The University of Chicago Press; 1982.
2. Karamitsos DT. The story of insulin discovery. Diabetes Res Clin Pract. 2011;93(Suppl 1):S2-8. doi: 10.1016/S0168-8227(11)70007-9
3. Best CH. Reminiscences of the Researches which Led to the Discovery of Insulin. Can Med Assoc J. 1942;47(5):398-400.
4. Rafuse J. Seventy-five years later, insulin remains Canada’s major medicalresearch coup. CMAJ.1996;155(9):1306-8.
5. Medvei VC. A History of Endocrinology. Lancaster, Boston: MTP Press Limited; 1982.
6. Paulesco NC. Action de l’extrait pancréatique injecté dans le sang, chez un animal diabétique. C.R. Soc. Biologie. 1921;85:555-559.
7. Lestradet H. [The discovery of insulin]. Bull Acad Natl Med.1996;180(2):437-45.
8. Jácome-Roca A. Historia de las hormonas. Bogotá: Academia Nacional de Medicina. Prismagraf Editores; 2008.
9. Opie EL. The relation of diabetes mellitus to lesions of the pancreas. Hyaline degeneration of the islands of Langerhans. J Exp Med. 1900;5(5):527- 40. doi: 10.1084/jem.5.5.527
10. Scott EL. On the influence of intravenous injections of an extract of the pancreas on experimental pancreatic diabetes. Am J Physiol. 1912;29(3):306- 10. doi: 10.1152/ajplegacy.1912.29.3.306
11. Kleiner IS. The action of intravenous injections of pancreas emulsions in experimental diabetes. J Biol Chem. 1919;40:153-70.
12. Murlin JR, Kramer B. The influence of pancreatic and duodenal extracts on the glycosuria and the respiratory metabolism of depancreatized dogs. Proc Soc Exp Biol Med. 1913;15:365-383.
13. Rosenfeld L. Insulin: discovery and controversy. Clin Chem. 2002;48(12):2270- 88.
14. Alpert JS. An Amazing Story: The Discovery of Insulin. Amer J Med. 2016;129(3):231-2. doi: 10.1016/j.amjmed.2016.01.001
15. Barron M. The relation of the islets of Langerhans to diabetes with special reference to cases of pancreatic lithiasis. Surg Gynec Obstet. 1920;31:437- 48.
16. Lewis RC, Benedict SR. A method for the estimation of sugar in small quantities of blood. J Biol Chem. 1915;20:61-72.
17. Folin O, Wu H. A system of blood analysis. Supplement I. A simplified and improved method for determination of sugar. J Biol Chem. 1920;41:367- 374.
18. Bliss M. Rewriting medical history: Charles Best and the Banting and Best myth. J Hist Med Allied Sci. 1993;48:253-74.
19. Collip JB. Frederick Grant Banting, discoverer of insulin. Sci Monthly. 1941;52:473-4.
20. Pratt JH. A reappraisal of researches leading to the discovery of insulin. J Hist Med Allied Sci. 1954;9(3):281-9.
21. Banting FG, Best CH, Collip JB, Campbell WR, Fletcher AA, Macleod JJR, Noble EC. The effect produced on diabetes by extracts of pancreas. Trans Assoc Am Physicians. 1922;37:337-47.
22. Banting FG, Best CH, Collip JB, Campbell WR, Fletcher AA. Pancreatic extracts in the treatment of diabetes mellitus. Preliminary report. Can Med Assoc J. 1922;12:141-6.
23. Banting FG, Best CH. The internal secretion of the pancreas. J Lab Clin Med. 1922;7(5):251-266.
24. Poulsen JE. The impact of August Krogh on the insulin treatment of diabetes and our present status. Acta Med Scand Suppl. 1975;578:7-14. doi: 10.1111/j.0954-6820.1975.tb06497.x
25. Cooper T, Ainsberg A. Breakthrough – Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle. New York: St. Martin’s Griffin Publishers; 2010.
26. Macleod JJR. The source of insulin. A study of the effect produced on blood sugar by extracts of the pancreas and principal islets of fishes. J Metab Res. 1922;2:149-72
27. Leiva A, Brugués E, Leiva-Pérez A. The discovery of insulin: Continued controversies after ninety years. Endocr Nutr. 2011;58(9):449-56. doi: 10.1016/j.endonu.2011.10.001
2. Karamitsos DT. The story of insulin discovery. Diabetes Res Clin Pract. 2011;93(Suppl 1):S2-8. doi: 10.1016/S0168-8227(11)70007-9
3. Best CH. Reminiscences of the Researches which Led to the Discovery of Insulin. Can Med Assoc J. 1942;47(5):398-400.
4. Rafuse J. Seventy-five years later, insulin remains Canada’s major medicalresearch coup. CMAJ.1996;155(9):1306-8.
5. Medvei VC. A History of Endocrinology. Lancaster, Boston: MTP Press Limited; 1982.
6. Paulesco NC. Action de l’extrait pancréatique injecté dans le sang, chez un animal diabétique. C.R. Soc. Biologie. 1921;85:555-559.
7. Lestradet H. [The discovery of insulin]. Bull Acad Natl Med.1996;180(2):437-45.
8. Jácome-Roca A. Historia de las hormonas. Bogotá: Academia Nacional de Medicina. Prismagraf Editores; 2008.
9. Opie EL. The relation of diabetes mellitus to lesions of the pancreas. Hyaline degeneration of the islands of Langerhans. J Exp Med. 1900;5(5):527- 40. doi: 10.1084/jem.5.5.527
10. Scott EL. On the influence of intravenous injections of an extract of the pancreas on experimental pancreatic diabetes. Am J Physiol. 1912;29(3):306- 10. doi: 10.1152/ajplegacy.1912.29.3.306
11. Kleiner IS. The action of intravenous injections of pancreas emulsions in experimental diabetes. J Biol Chem. 1919;40:153-70.
12. Murlin JR, Kramer B. The influence of pancreatic and duodenal extracts on the glycosuria and the respiratory metabolism of depancreatized dogs. Proc Soc Exp Biol Med. 1913;15:365-383.
13. Rosenfeld L. Insulin: discovery and controversy. Clin Chem. 2002;48(12):2270- 88.
14. Alpert JS. An Amazing Story: The Discovery of Insulin. Amer J Med. 2016;129(3):231-2. doi: 10.1016/j.amjmed.2016.01.001
15. Barron M. The relation of the islets of Langerhans to diabetes with special reference to cases of pancreatic lithiasis. Surg Gynec Obstet. 1920;31:437- 48.
16. Lewis RC, Benedict SR. A method for the estimation of sugar in small quantities of blood. J Biol Chem. 1915;20:61-72.
17. Folin O, Wu H. A system of blood analysis. Supplement I. A simplified and improved method for determination of sugar. J Biol Chem. 1920;41:367- 374.
18. Bliss M. Rewriting medical history: Charles Best and the Banting and Best myth. J Hist Med Allied Sci. 1993;48:253-74.
19. Collip JB. Frederick Grant Banting, discoverer of insulin. Sci Monthly. 1941;52:473-4.
20. Pratt JH. A reappraisal of researches leading to the discovery of insulin. J Hist Med Allied Sci. 1954;9(3):281-9.
21. Banting FG, Best CH, Collip JB, Campbell WR, Fletcher AA, Macleod JJR, Noble EC. The effect produced on diabetes by extracts of pancreas. Trans Assoc Am Physicians. 1922;37:337-47.
22. Banting FG, Best CH, Collip JB, Campbell WR, Fletcher AA. Pancreatic extracts in the treatment of diabetes mellitus. Preliminary report. Can Med Assoc J. 1922;12:141-6.
23. Banting FG, Best CH. The internal secretion of the pancreas. J Lab Clin Med. 1922;7(5):251-266.
24. Poulsen JE. The impact of August Krogh on the insulin treatment of diabetes and our present status. Acta Med Scand Suppl. 1975;578:7-14. doi: 10.1111/j.0954-6820.1975.tb06497.x
25. Cooper T, Ainsberg A. Breakthrough – Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle. New York: St. Martin’s Griffin Publishers; 2010.
26. Macleod JJR. The source of insulin. A study of the effect produced on blood sugar by extracts of the pancreas and principal islets of fishes. J Metab Res. 1922;2:149-72
27. Leiva A, Brugués E, Leiva-Pérez A. The discovery of insulin: Continued controversies after ninety years. Endocr Nutr. 2011;58(9):449-56. doi: 10.1016/j.endonu.2011.10.001
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