Palabras clave
Vitamina D
osteoporosis
densidad mineral ósea
hiperparatiroidismo secundario
sarcopenia
vitamin D
bone mineral density
secondary hyperparathyroidism
osteoporosis
densidad mineral ósea
hiperparatiroidismo secundario
sarcopenia
vitamin D
bone mineral density
secondary hyperparathyroidism
Cómo citar
Rosero Olarte, O. (2017). Vitamina D y salud ósea en la mujer posmenopáusica. Revisión. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 2(1), 14–19. https://doi.org/10.53853/encr.2.1.66
Resumen
La vitamina D es un determinante importante de la salud ósea y de la función neuromuscular. Recientemente se ha catalogado el déficit de vitamina D como un problema epidémico de proporción mundial.
Evidencia reciente sugiere que el aporte de vitamina D en dosis suficiente disminuye el riesgo de fracturas, así como el riesgo de presentar caídas en pacientes ancianos.
Mantener un nivel adecuado de vitamina D es una práctica simple y poco costosa que contribuye a disminuir las consecuencias que su déficit representa para la salud ósea.
Abstract
Vitamin D is an important determinant of bone health and neuromuscular function. Vitamin D deficiency is now recognized as a worldwide epidemic.
Recent evidence suggests that vitamin D intake in a sufficient dose decreases the risk of fractures and falls among elderly patients.
It takes a simple and low-cost practice to maintain vitamin D at suitable levels, thus contributing to decrease the consequences that its deficit entails for bone health.
Citas
1. Holick MF. Vitamin D: Photobiology, metabolism, mechanism of action, and clinical applications. Flavus M. editor. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. American society for Bone and Mineral Research. Washington D.C. 2003; 129-137.
2. Holick MF. Vitamin D Deficiency. N Engl J Med 2007; 357:266-281.
3. Dusso A, Brown J, Slatopolsky E. Vitamin D. Am J Renal Physiol; 2005; 289: F8-F28.
4. Bouillon R. Vitamin D From photosyntesis, metabolism and action to clinical applications. De Groot LJ, Jamerson LJ. editors. Endocrinology. Philadelphia; WB Saunders; 2001; 1009-1035.
5. Kurnik B, Hruska K. Mechanism of stimulation of renal phosphate transport by 1,25-dihydroxycholecaiciferol. Biochim Biophys Acta; 1985; 817: 42-50.
6. Lips P. Vitamin D Deficiency and Secondary Hyperparathyroidism in the Elderly: Consequences for Bone Loss and Fractures and Therapeutic Implications. Endocrine Reviews; 2001; 22(4): 477-501.
7. Stejskal D, Bartek J, Pastrokova R, et al. Osteoprotegerin, RANK, RANKL. Biomed Papers; 2001; 145:61-64.
8. Lips P. The effect of vitamin D supplementation on vitamin D status and Parathyroid Function in elderly subjects. J Clin Endocrinol Metab; 1988; 67: 644-650.
9. Bruce D, St John A, Nicklason F, et al. Secondary Hyperparathyroidism in Patients from Western Australia with Hip Fracture: Relationship to Type of Hip Fracture, Renal Function, and Vitamin D Deficiency. J American Geriat rics Society; 1999; 47 (3): 354-359.
10. Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of Vitamin D Insufficiency in an Adult Normal Population. Osteoporos Int; 1997; 7:439-443.
11. Okumus M, Koybas? M, Tuncay F, et al Fibromyalgia syndrome: is it related to vitamin D deficiency in premenopausal female patients? Pain Manag Nurs. 2013 Dec;14(4):e156-161.
12. Jesus CA, Feder D, Peres MF. The role of vitamin D in pathophysiology and treatment of fibromyalgia. Curr Pain Headache Rep. 2013; 17(8):355-362.
13. Guilsun Kim, Ki Won Oh, Eun-Hee Jang et al. Relationship between Vitamin D, Parathyroid Hormone, and Bone Mineral Density in Elderly Koreans. J Korean Med Sci 2012; 27: 636-643.
14. Le Boff MS, Kohlmeier L, Hurwitz S. Occult vitamin D deficiency in postmenopausal US woman with acute hip fracture. JAMA; 1999; 281:1505-1511.
15. Kristin Holvik, Luai A. Ahmed, Siri Forsmo. Low Serum Levels of 25-Hydroxyvitamin D Predict Hip Fracture in the Elderly: A NOREPOS Study J Clin Endocrinol Metab 2013 98:8, 3341-3350.
16. Alfonso J. Cruz-Jentoft1, Jean Pierre Baeyens, Jürgen M. Bauer et al Sarcopenia: European consensus on definition and diagnosisReport of the European Working Group on Sarcopenia in Older People. Age Ageing 2010: 39 (4): 412-423.
17. Holick MF. High prevalence of vitamin D inadequacy and implications for Health. Mayo Clin Proc; 2006; 81: 353-373.
18. Christian M. Girgis, Roderick J. Clifton-Bligh et al. The Roles of Vitamin D in Skeletal Muscle: Form, Function, and Metabolism. Endocr Rev. 2013 Feb;34(1):33-83.
19. Dawson H, Heaney RP, Holick MF. Estimation of optimal vitamin D status. Osteoporos Int; 2005; 16: 713-716.
20. Priemel M. Von Domarus C, Klatte TO. Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675?patients. J Bon Miner Res 2010; 25, 2, :305–312.
21. Holick MF, Siris E, Binkley N. Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving Osteoporosis Therapy. J Clin Endocrinol Metab; 2005; 90: 3215-3224.
22. Nesby-O’Dell S, Scanlon K, Cogswell M. et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age. Am J Clin Nutr; 2002; 76: 187-192.
23. Rodríguez J, Valdivia G, Trincado P. Fracturas vertebrales osteoporosis y vitamina D en la postmenopausia. Estudio en 555 mujeres en Chile. Rev Med Chile; 2007; 135: 31-36.
24. Binkley N, Novotny R, Krueger D. Low Vitamin D Status despite Abundant Sun Exposure. J Clin Endocrinol Metab; 2007; 92: 2130-2135.
25. Deyanira, González Devia; Claudia, Zúñiga Libreros; William, Kattah Calderón. Insuficiencia de vitamina D en pacientes adultos con baja masa ósea y osteoporosis en la Fundación Santa Fe de Bogotá 2008-2009 / Vitamin D insufficiency in adults patients with low bone mass and osteoporosis in the Fundación Santa Fe de Bogotá 2008-2009. Rev.Colomb.Reumatol.; 17(4); 212-218; 2010-09
26. Molina JF, Molina J, Jorge, Escobar JA. et al Niveles de 25 hidroxivitamina D y su correlación clínica con diferentes variables metabólicas y cardiovasculares en una población de mujeres posmenopáusicas. Acta Med Colomb 2011; 36: 18-23.
27. María Patricia, Hormaza; Diana, Cuesta; Lina María, Martínez; Mónica María, Massaro; María Nazareth, Campo; María del Pilar, Vélez; Gabriel Jaime, Rendón; Camilo Andrés, Agudelo. Niveles séricos de 25 hidroxivitamina d en mujeres no menopáusicas, menopáusicas y posmenopáusicas. Rev Colomb Obstet Ginecol; 62(3); 231-236; 2011-09.
28. Chel VGM, Ooms ME, Pooo-Snijders L, et al. Ultraviolet Irradiation Corrects Vitamin D Deficiency and Suppresses Secondary Hyperparathyroidism in the Elderly. J Bone Miner Res; 1998; 13: 1238-1242.
29. The American Academic of dermatology. Position Statement on Vitamin D. http://www.aad.org/Forms/Policies/Uploads/PS/PSVitamin%20D%20 Postition%20Statement.pdf
30. Brazier M, Kamel S, Maamer M. et al. Markers of bone remodelling in the elderly subject: effects of vitamin d insufficiency and its correction. J Bone Miner Res; 1995; 10: 1753-1761.
31. Prestwood KM, Pannullo AM, Kenny AM, et al. The effect of a short course of calcium and vitamin D on bone turnover in older women. Osteoporos Int; 1996; 6:314-319.
32. Sakalli H, Arslan D , Yucel AE. The efect of oral and parenteral vitamin D supplementation in the elderly: a prospective, double-blinded, randomized, placebo-controlled study.; Rheumatol Int; 2012: 32:2279–2283.
33. Grimnes G, Joakimsen R, Figenschau Y, Torjesen PA, Almås B, Jorde R. The effect of high-dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass--a randomized controlled 1-year trial. Osteoporos Int. 2012: 23(1):201-11.
34. Ooms M, Roos J, Bezemer P, et al. Prevention of bone loss by Vitamin D supplementation in elderly women: a randomized double-blind trial. J Clin Endocrinol Metab; 1995; 80:1052-1058.
35. Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014 11;383 (9912):146-55.
36. Boonen S, Bischoff F, Cooper C, et al. Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int; 2006; 78: 257-270.
37. Murad MH, Elamin KB, Abu Elnour NO, Elamin MB, Alkatib AA, Fatourechi MM et al. Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011; 96(10):2997-3006
38. Kattah W. Epidemiología de osteoporosis algunos datos de la población mundial. Revista Colombiana de Menopausia; 1995; 1 (2) 33-35.
39. Bischoff H, Willett W, Wong J, et al. Fracture prevention With vitamin D supplementation. JAMA; 2005; 293; 2257-2264.
40. Heike A. Bischoff F, Walter C. Willett, E,Lips P, Meunier PJ, Ronan A. et al. A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention. N Engl J Med 2012; 367:40-49.
41. Holick MF, Binkley N, Bischoff-Ferrari, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011, 96(7):1911–1930.
42. Fahad Alshahrani, Naji Aljohani. Vitamin D: Deficiency, Sufficiency and Toxicity. Nutrients. 2013; 5 (9):3605-3616.
2. Holick MF. Vitamin D Deficiency. N Engl J Med 2007; 357:266-281.
3. Dusso A, Brown J, Slatopolsky E. Vitamin D. Am J Renal Physiol; 2005; 289: F8-F28.
4. Bouillon R. Vitamin D From photosyntesis, metabolism and action to clinical applications. De Groot LJ, Jamerson LJ. editors. Endocrinology. Philadelphia; WB Saunders; 2001; 1009-1035.
5. Kurnik B, Hruska K. Mechanism of stimulation of renal phosphate transport by 1,25-dihydroxycholecaiciferol. Biochim Biophys Acta; 1985; 817: 42-50.
6. Lips P. Vitamin D Deficiency and Secondary Hyperparathyroidism in the Elderly: Consequences for Bone Loss and Fractures and Therapeutic Implications. Endocrine Reviews; 2001; 22(4): 477-501.
7. Stejskal D, Bartek J, Pastrokova R, et al. Osteoprotegerin, RANK, RANKL. Biomed Papers; 2001; 145:61-64.
8. Lips P. The effect of vitamin D supplementation on vitamin D status and Parathyroid Function in elderly subjects. J Clin Endocrinol Metab; 1988; 67: 644-650.
9. Bruce D, St John A, Nicklason F, et al. Secondary Hyperparathyroidism in Patients from Western Australia with Hip Fracture: Relationship to Type of Hip Fracture, Renal Function, and Vitamin D Deficiency. J American Geriat rics Society; 1999; 47 (3): 354-359.
10. Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of Vitamin D Insufficiency in an Adult Normal Population. Osteoporos Int; 1997; 7:439-443.
11. Okumus M, Koybas? M, Tuncay F, et al Fibromyalgia syndrome: is it related to vitamin D deficiency in premenopausal female patients? Pain Manag Nurs. 2013 Dec;14(4):e156-161.
12. Jesus CA, Feder D, Peres MF. The role of vitamin D in pathophysiology and treatment of fibromyalgia. Curr Pain Headache Rep. 2013; 17(8):355-362.
13. Guilsun Kim, Ki Won Oh, Eun-Hee Jang et al. Relationship between Vitamin D, Parathyroid Hormone, and Bone Mineral Density in Elderly Koreans. J Korean Med Sci 2012; 27: 636-643.
14. Le Boff MS, Kohlmeier L, Hurwitz S. Occult vitamin D deficiency in postmenopausal US woman with acute hip fracture. JAMA; 1999; 281:1505-1511.
15. Kristin Holvik, Luai A. Ahmed, Siri Forsmo. Low Serum Levels of 25-Hydroxyvitamin D Predict Hip Fracture in the Elderly: A NOREPOS Study J Clin Endocrinol Metab 2013 98:8, 3341-3350.
16. Alfonso J. Cruz-Jentoft1, Jean Pierre Baeyens, Jürgen M. Bauer et al Sarcopenia: European consensus on definition and diagnosisReport of the European Working Group on Sarcopenia in Older People. Age Ageing 2010: 39 (4): 412-423.
17. Holick MF. High prevalence of vitamin D inadequacy and implications for Health. Mayo Clin Proc; 2006; 81: 353-373.
18. Christian M. Girgis, Roderick J. Clifton-Bligh et al. The Roles of Vitamin D in Skeletal Muscle: Form, Function, and Metabolism. Endocr Rev. 2013 Feb;34(1):33-83.
19. Dawson H, Heaney RP, Holick MF. Estimation of optimal vitamin D status. Osteoporos Int; 2005; 16: 713-716.
20. Priemel M. Von Domarus C, Klatte TO. Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675?patients. J Bon Miner Res 2010; 25, 2, :305–312.
21. Holick MF, Siris E, Binkley N. Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving Osteoporosis Therapy. J Clin Endocrinol Metab; 2005; 90: 3215-3224.
22. Nesby-O’Dell S, Scanlon K, Cogswell M. et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age. Am J Clin Nutr; 2002; 76: 187-192.
23. Rodríguez J, Valdivia G, Trincado P. Fracturas vertebrales osteoporosis y vitamina D en la postmenopausia. Estudio en 555 mujeres en Chile. Rev Med Chile; 2007; 135: 31-36.
24. Binkley N, Novotny R, Krueger D. Low Vitamin D Status despite Abundant Sun Exposure. J Clin Endocrinol Metab; 2007; 92: 2130-2135.
25. Deyanira, González Devia; Claudia, Zúñiga Libreros; William, Kattah Calderón. Insuficiencia de vitamina D en pacientes adultos con baja masa ósea y osteoporosis en la Fundación Santa Fe de Bogotá 2008-2009 / Vitamin D insufficiency in adults patients with low bone mass and osteoporosis in the Fundación Santa Fe de Bogotá 2008-2009. Rev.Colomb.Reumatol.; 17(4); 212-218; 2010-09
26. Molina JF, Molina J, Jorge, Escobar JA. et al Niveles de 25 hidroxivitamina D y su correlación clínica con diferentes variables metabólicas y cardiovasculares en una población de mujeres posmenopáusicas. Acta Med Colomb 2011; 36: 18-23.
27. María Patricia, Hormaza; Diana, Cuesta; Lina María, Martínez; Mónica María, Massaro; María Nazareth, Campo; María del Pilar, Vélez; Gabriel Jaime, Rendón; Camilo Andrés, Agudelo. Niveles séricos de 25 hidroxivitamina d en mujeres no menopáusicas, menopáusicas y posmenopáusicas. Rev Colomb Obstet Ginecol; 62(3); 231-236; 2011-09.
28. Chel VGM, Ooms ME, Pooo-Snijders L, et al. Ultraviolet Irradiation Corrects Vitamin D Deficiency and Suppresses Secondary Hyperparathyroidism in the Elderly. J Bone Miner Res; 1998; 13: 1238-1242.
29. The American Academic of dermatology. Position Statement on Vitamin D. http://www.aad.org/Forms/Policies/Uploads/PS/PSVitamin%20D%20 Postition%20Statement.pdf
30. Brazier M, Kamel S, Maamer M. et al. Markers of bone remodelling in the elderly subject: effects of vitamin d insufficiency and its correction. J Bone Miner Res; 1995; 10: 1753-1761.
31. Prestwood KM, Pannullo AM, Kenny AM, et al. The effect of a short course of calcium and vitamin D on bone turnover in older women. Osteoporos Int; 1996; 6:314-319.
32. Sakalli H, Arslan D , Yucel AE. The efect of oral and parenteral vitamin D supplementation in the elderly: a prospective, double-blinded, randomized, placebo-controlled study.; Rheumatol Int; 2012: 32:2279–2283.
33. Grimnes G, Joakimsen R, Figenschau Y, Torjesen PA, Almås B, Jorde R. The effect of high-dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass--a randomized controlled 1-year trial. Osteoporos Int. 2012: 23(1):201-11.
34. Ooms M, Roos J, Bezemer P, et al. Prevention of bone loss by Vitamin D supplementation in elderly women: a randomized double-blind trial. J Clin Endocrinol Metab; 1995; 80:1052-1058.
35. Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014 11;383 (9912):146-55.
36. Boonen S, Bischoff F, Cooper C, et al. Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int; 2006; 78: 257-270.
37. Murad MH, Elamin KB, Abu Elnour NO, Elamin MB, Alkatib AA, Fatourechi MM et al. Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011; 96(10):2997-3006
38. Kattah W. Epidemiología de osteoporosis algunos datos de la población mundial. Revista Colombiana de Menopausia; 1995; 1 (2) 33-35.
39. Bischoff H, Willett W, Wong J, et al. Fracture prevention With vitamin D supplementation. JAMA; 2005; 293; 2257-2264.
40. Heike A. Bischoff F, Walter C. Willett, E,Lips P, Meunier PJ, Ronan A. et al. A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention. N Engl J Med 2012; 367:40-49.
41. Holick MF, Binkley N, Bischoff-Ferrari, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011, 96(7):1911–1930.
42. Fahad Alshahrani, Naji Aljohani. Vitamin D: Deficiency, Sufficiency and Toxicity. Nutrients. 2013; 5 (9):3605-3616.
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