Keywords
Hipotálamo
hipófisis
tiroides
interrelaciones hipotálamo-hipófiso-tiroideas
hipófisis
tiroides
interrelaciones hipotálamo-hipófiso-tiroideas
How to Cite
Otero-Ruiz, E. (2018). Hipotálamo, Hipófisis y Tiroides. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, -3(1), 53–65. https://doi.org/10.53853/encr.-3.1.347
Abstract
- Aún cuando existe mutua dependencia humoral (servomecanismo) entre hipófisis y tiroides, la capacidad de respuesta hipofisaria se halla presumiblemente regulada por el hipotálamo a través de un mediador humoral través de un mediador humoral de tipo nervioso o endocrino, de naturaleza no bien establecida hasta el presente.
- La hipófisis segrega una hormona tiroestimulante cuyo efecto principal es la aceleración del metabolismo de yodo por la glándula y que secundariamente produce aumento morfológico. La hormona es una glicoproteina caracterizable química (?) e inmunológicamente y dosificable por métodos biológicos. Estos últimos han permitido la identificación de un factor tiroestimulante "anormal" o "retardado" « en algunos casos de enfermedad de Basedow-Graves. El posible papel de la TSH, normal o anormal, en la etiología del hipertiroidismo, está todavía por aclararse.
References
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4. BROWN-GRANT, K.: The hypothalamus and the thyroid gland. Brit. Med. Bull. 16:165-169 (May) 1960.
5. WOLFF, J. AND GOLDBERG, R.C.: Disoders of iodine metabolism. En Thompson, R. H. ANI) KING, E. J.: Biochemical disorders in human disease. Academic Press, N. Y. 1957.
Pp. 289-351.
6. HARRIS, G. W.: Neural control of the pituitary gland. Arnold
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7. McCULLAGH, E. P., CLAMEN, M. GARDNER, W., J., KENNE
DY, R. J. AND LOCKHART, G.: Exophtalmos of Graves' disease: a summary of the present status of therapy. Ann. Int. Med. 48:445-470 (March) 1958.
8. NIKITOVICH-WINER, M. AND EVERETT, J.: Functional restitution of pituitary grafts retransplanted from kidney to median eminence. Endocrinology 63:916-930 (Dec.) 1958.
9. NIKITOVICH-WINER, M. AND EVERETT, J.: Histocytologic
changes in grafts of rat pituitary on the kidney and upon retransplantation under the diencephalon. Endocrinology 65:
357-368 (Sept.) 1959.
10. GREER. M. A.: The role of the hypothalamus in the control of thyroid function. J. Clin. Endocr. & Metab. 12:1259-1268 (Oct.) 1952.
11. HALMI. N. S. SPIRTOS, B. N., BOGDANOVE, E. M. AND LIP
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12. BOGDANOVE, E. M.. SPIRTOS, B. N. AND HALMI, N. S.: Further observations on pituitary structure and function in rats bearing hypotalamic lesions. Endocrinology 57:302-315
(Sept.) 1955.
13. BOGDANOVE, EE.M. AND BOGDANOVE, J. N.: Thyroid weight, microscopic structure and radioiodine concentration at various levels of thyrotropin secretion in the goitrogen-treated rat. Endocrinology 61:52-58 (July) 1957.
14. D'ANGELO, S.A. AND TRAUM, R.: Pituitary-thyroid function in rats with hypothalamic lesions. Endocrinology 59:593-595
(Nov.) 1956.
15. BOGDANOVE, F. M. AND D' ANGELO, S. A.: The effec of hypothalamic lesions on goitrogenesis and pituitary TSH secretion in the propyl-thiouracil treated guinea-pig. Endocrinology 6-1:53-61 (Jan.) 1959.
16. GREER., M. A.: Comunicación personal. (11th. Post-Grad. Assembly in Endocrinology and Meabolism, Endocrine Society,
San Francisco, Nov. 1959).
17. GREER, M. A.: Correlation of radioiodine uptake with thyroid weight in the mouse at various levels of exogenous and endogenous thyrotropin stimulation. Endocrinology 64: 724-729 (May) 1959.
18. FLORSHEIM, W. H.: The effec of anterior hypothalmic lesions on thyroid function and goiter development in the rat. Endocrinology 62:783-789 (June) 1958.
19. FLORSHEIM, W. H.: influence of hypothalamus on pituitary-thyroid axis in the rai. Proc. Soc. Exp. Biol. & Med. 100:73 (Jan.) 1959.
20. HARRIS, G. W. AND WOODS, J. W : Hypothalamus-pituitary
thyroic relationships. Ciba. Found. Coll. on Endocrinology.
Vol. 10, 1957. Pp. 3-20.
21. ANDERSON, E., BATES. R. W.. HAWTHORNE, E., HAYMAKER, W. KNOWLTON, K., RIOCI, D, SPENCE w. T. WILSON, H.: The efects of midbrain and spinal cord transection on endocrine and metabolic function with postulation of a midorain hypothalamico pituitary activating system. Recent
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22. FORD, D. 1. AND GROSS, J.: The localization of 1-131 labeled triiodothyronine and thyroxine in the pituitary and brain of the male guinea-pig. Endocrinology 63:549-555 (Nov.) 1958.
23. FORD, D. II., KANTOUNIS, S AND LAWRENCE, R.: The localization of I-131 labeled triidothyronine in the pituitary and brain of normal and thyroidectomized male rats. Endocrinology 64:977-991 (June) 1959.
24. YAMADA, T, AND GREER, M. A.: Studies on the mechanism of hypothalamic control of thyrotropin secretion effect of thyroxine injection into the hypothalamus or the pituitary on thyroid iiormone release. Endocrinology 64.559-556 (April)
1959.
25. GREER. N. A.. YAMADA, T. AND JINO, S.: The participation of the central nervous system in the control of thyroid function Ann. N. Y. Acad. of Sciences Sti: 667-675 (April) 1960.
26. ROSE, S., NELSON, J. AND BRADLEY. 1. R.: Regulation of TSH release. Ann. N.Y. Acad. of Sciences 86:647-656 (April)
1960.
27. CROWN, J., LABELLA, F. AND ULVEDAL, F.: Studies on the
intracellular localization of anterior pituitary hormones by means of differential centrifugation, Endocrinology 66:1-12
(Jan.) 1960.
28. PURVES, TH. D. AND GRIESBACH, W. E.: Pituitary cytology in on Endocrinology Vol. 10. 1937. Pp. 51-58.
29. FURTH, J., DENT', J. BURNETT', W. AND GADSDEN, E.: The
mechanism of induction and the characteristics of pituitary tumors induced by thyroidectomy. J. Clin. Endocr. & Me:
tab. 15:81-97 (Jan.) 1953.
30. DENT, J., GADSDEN, E AND FURTH, J.: On the relation bet
ween thyroid depression and pituitary tumor inäuction in
mice. Cancer Research 15:70-75 (Jan.) 1955.
31. DENT, J., GADSDEN, E. AND FURTII, J.: Further studies on induction and growth of thyrotropic pituitary tumors in mice.
Cancer Res 16:171-174 (Feb.) 1956.
32. FURTH, J. AND CLIFTON, K. II.: Experimental pituitary tumors and the role of pituitary hormones in tumorigenesis of the breast and thyroid Cancer 10:842-853 (Jul-Aug.) 1957.
33. RAWSON, R, W. AND MONEY, W. L.: Comunicación personal (11 th. Post- Grad Assembly in Endocrinology and Metabolism, Endocrine Soc. San Francisco, No. 1959).
33a. MONEY, W. L., KUMAOKA, S., RAWSON, R. W. AND KROC,
R. L : Comparative effects of thyroxine analogues in experimental animals. Ann4 N. Y. Acad. of Sciencies 86:512-544 (Aprii) 1960
34. PIERCE, J, G., CARSTEN, M. E. AND WYNSTON, L. K.: Purification and chemistry of the thyroid stimulating hormone. Ann. N.Y. Acad. of Sciencies 86:612-624 (April) 1960. 35. PURVES, H. D. AND ADAMS, D.D.: Thyroid-stimulating hormone. Brit. Med. Bull. 16:128-132 (May) 1960.
36. WERNER, S. C., OTERO-RUIZ, E., BATES, R. W. AND SIEGEL.
B.: Neutralization of human serum pituitary thyrotropic fractions with antiesra to bovine pituitary Thyrotropin. Nature 185: 472-473 (Feb) 1960.
37. CLINE. M. J., SELENKO0, H. A. AND BOOKE, M. S.: Inhibition of thyrotropic activity by inniunologically specific an
tiserum. Endocrinology 67:273-276 (Aug.) 1960
38. HALMI. N. S.: Factors influencing the thyroidal iodine pump. Ciba Found. Coll. on Endocrinology. Vol 10, 1957. Pp. 79-96.
39. SONENBERG, M. AND MONEY, W. L.: Chemical derivatives of thyroid stimulating hormone preparations. Ann. N.Y. Acad.
of Sciences 86:625-646 (April) 1960.
40. SMITH, P.E. AND SMITII, L.P.: J. Med. Research 43:267, 1922. Citado por Purves & Adams (35).
41. BROWN, J. R.: The measurement of thyroid-stimulating hormone (TSH) in body bluids: a critical review. Acta Endocrinologica 32:289-309, 1959.
42. BAKKE. J. ... HEIDEMANN, L... LAWRENCE, N. AND WIDERG,
C. Endocrinology G1:252, 1957.
41b. D'ANGELO, S. A, AND GORDON, A. S. Endrocrinology 46-39, 1950.
41c. HENRY, 1:. AND BLOCITE-MICHEL. 1.: Ann. Endocr. Paris 16:258, 1955.
41d. QUERIDO, A., KASSENAAR. A. II. AND LAMEIJER, L.D.: Acta
Endo. Copenhagen 12:335. 1953.
41e. KRISS. J.P. AND GREENSPAN, F.S.: J. Clin. Endocr. & Me.
tab. 14:770, 1951.
41f. GILLILAND, IC. AND STRUDWICK, J.!.: Clin Science. 12:265 1953.
41g. ADAMS, D.D. AND PURVES, U. D: Endocrinology 57:17, 1955.
41h. McKENZIE, J.M.: Fderations Proceedings 16:17, 1957.
42. GREER. M.A. AND SHULL. II. T.: A quantitative study of the
effect of thyrotropin upon the thyroidal secretion rate in euthyroid and thyrotoxic subjects. J. Clin. Endocr. & Me
tab 07:1030-1099 (Sept.) 1957.
43. ADAMS, D.D.: The presence of an abnormal TSH in the serum of some thyrotoxic patients. J. Clin. Endocr. & Metab. 18:699 712 (July) 1958.
44. MCKENZIE, J. M.: Delaved thyroid response to serum from thyro-toxic patients. Endocrinology 62:863-868 (June) 1958.
45. ADAMS, D.D.. PURVES, II.D. AND SIRETT. N. E.. The response of hypophysectomized mice to injection of human serum ( thyroic stimulator. Endocrinology 68:154-155 (Jan.) 1961.
46. DOBYNS. B. M. AND WILSON, L.A.: An exophalamos-producing substance in the serum of patients suffering from progressive exophtalmos. J. Clin. Endocr. & Metab. 14:1392-1102 (Nov.) 1954.
47. WERNER. S.C.. HAMILTON. JI. AND NEMETIT, N.: Graves'disease: Hyperthyroidism or hyperpituitarism? J. Clin. Endocr. & Metab. 12:1561-1571 (Dec.) 1952.
48. A.W.G. Effect of thyrotropic hormone on the accumulation of radioative iodine in thyrotoxicosis. J. Clin. En
docr. & Metab. 19:1252-1257 (Oct.) 1959.
49. WERNER. S.C AND WELLINGTON, S.: Hyperthyroidism in a
patient with a pituitary chromophobe adenoma and a fragment of normal pituitary. J. Clin. Endocr. & Metab. 18:266-270 (March) 1958.
50. FAJANS, S: Hyperthyroidism in a a patient with post-partum necrosis of the pituitary: case report and implication. J. Clin. Endocr. & Metab. 18:271-277 (March) 1958.
(2).
2. BROWN-GRANT, K.: The "feed-back" hypothesis of the control of thyroid function. Ciba Found. Coll. on Endocrinology, Vol. 10, 1957. Pp. 97-116.
3. GREER, M.A.: The influence of the central nervous system on the Control of thyrotropin secretion. Ciba Foun. Coll. on Endocrinology Vol. 10, 1957. Pp. 34-47.
4. BROWN-GRANT, K.: The hypothalamus and the thyroid gland. Brit. Med. Bull. 16:165-169 (May) 1960.
5. WOLFF, J. AND GOLDBERG, R.C.: Disoders of iodine metabolism. En Thompson, R. H. ANI) KING, E. J.: Biochemical disorders in human disease. Academic Press, N. Y. 1957.
Pp. 289-351.
6. HARRIS, G. W.: Neural control of the pituitary gland. Arnold
Publ. London, 1955.
7. McCULLAGH, E. P., CLAMEN, M. GARDNER, W., J., KENNE
DY, R. J. AND LOCKHART, G.: Exophtalmos of Graves' disease: a summary of the present status of therapy. Ann. Int. Med. 48:445-470 (March) 1958.
8. NIKITOVICH-WINER, M. AND EVERETT, J.: Functional restitution of pituitary grafts retransplanted from kidney to median eminence. Endocrinology 63:916-930 (Dec.) 1958.
9. NIKITOVICH-WINER, M. AND EVERETT, J.: Histocytologic
changes in grafts of rat pituitary on the kidney and upon retransplantation under the diencephalon. Endocrinology 65:
357-368 (Sept.) 1959.
10. GREER. M. A.: The role of the hypothalamus in the control of thyroid function. J. Clin. Endocr. & Metab. 12:1259-1268 (Oct.) 1952.
11. HALMI. N. S. SPIRTOS, B. N., BOGDANOVE, E. M. AND LIP
NER, H. L.: Endocrinology 52:19-27, 1953. Citado por Bogdanove (12).
12. BOGDANOVE, E. M.. SPIRTOS, B. N. AND HALMI, N. S.: Further observations on pituitary structure and function in rats bearing hypotalamic lesions. Endocrinology 57:302-315
(Sept.) 1955.
13. BOGDANOVE, EE.M. AND BOGDANOVE, J. N.: Thyroid weight, microscopic structure and radioiodine concentration at various levels of thyrotropin secretion in the goitrogen-treated rat. Endocrinology 61:52-58 (July) 1957.
14. D'ANGELO, S.A. AND TRAUM, R.: Pituitary-thyroid function in rats with hypothalamic lesions. Endocrinology 59:593-595
(Nov.) 1956.
15. BOGDANOVE, F. M. AND D' ANGELO, S. A.: The effec of hypothalamic lesions on goitrogenesis and pituitary TSH secretion in the propyl-thiouracil treated guinea-pig. Endocrinology 6-1:53-61 (Jan.) 1959.
16. GREER., M. A.: Comunicación personal. (11th. Post-Grad. Assembly in Endocrinology and Meabolism, Endocrine Society,
San Francisco, Nov. 1959).
17. GREER, M. A.: Correlation of radioiodine uptake with thyroid weight in the mouse at various levels of exogenous and endogenous thyrotropin stimulation. Endocrinology 64: 724-729 (May) 1959.
18. FLORSHEIM, W. H.: The effec of anterior hypothalmic lesions on thyroid function and goiter development in the rat. Endocrinology 62:783-789 (June) 1958.
19. FLORSHEIM, W. H.: influence of hypothalamus on pituitary-thyroid axis in the rai. Proc. Soc. Exp. Biol. & Med. 100:73 (Jan.) 1959.
20. HARRIS, G. W. AND WOODS, J. W : Hypothalamus-pituitary
thyroic relationships. Ciba. Found. Coll. on Endocrinology.
Vol. 10, 1957. Pp. 3-20.
21. ANDERSON, E., BATES. R. W.. HAWTHORNE, E., HAYMAKER, W. KNOWLTON, K., RIOCI, D, SPENCE w. T. WILSON, H.: The efects of midbrain and spinal cord transection on endocrine and metabolic function with postulation of a midorain hypothalamico pituitary activating system. Recent
Progr. Hormone Res. Acad. Press, N. Y. 1957. Pp. 21-59.
22. FORD, D. 1. AND GROSS, J.: The localization of 1-131 labeled triiodothyronine and thyroxine in the pituitary and brain of the male guinea-pig. Endocrinology 63:549-555 (Nov.) 1958.
23. FORD, D. II., KANTOUNIS, S AND LAWRENCE, R.: The localization of I-131 labeled triidothyronine in the pituitary and brain of normal and thyroidectomized male rats. Endocrinology 64:977-991 (June) 1959.
24. YAMADA, T, AND GREER, M. A.: Studies on the mechanism of hypothalamic control of thyrotropin secretion effect of thyroxine injection into the hypothalamus or the pituitary on thyroid iiormone release. Endocrinology 64.559-556 (April)
1959.
25. GREER. N. A.. YAMADA, T. AND JINO, S.: The participation of the central nervous system in the control of thyroid function Ann. N. Y. Acad. of Sciences Sti: 667-675 (April) 1960.
26. ROSE, S., NELSON, J. AND BRADLEY. 1. R.: Regulation of TSH release. Ann. N.Y. Acad. of Sciences 86:647-656 (April)
1960.
27. CROWN, J., LABELLA, F. AND ULVEDAL, F.: Studies on the
intracellular localization of anterior pituitary hormones by means of differential centrifugation, Endocrinology 66:1-12
(Jan.) 1960.
28. PURVES, TH. D. AND GRIESBACH, W. E.: Pituitary cytology in on Endocrinology Vol. 10. 1937. Pp. 51-58.
29. FURTH, J., DENT', J. BURNETT', W. AND GADSDEN, E.: The
mechanism of induction and the characteristics of pituitary tumors induced by thyroidectomy. J. Clin. Endocr. & Me:
tab. 15:81-97 (Jan.) 1953.
30. DENT, J., GADSDEN, E AND FURTH, J.: On the relation bet
ween thyroid depression and pituitary tumor inäuction in
mice. Cancer Research 15:70-75 (Jan.) 1955.
31. DENT, J., GADSDEN, E. AND FURTII, J.: Further studies on induction and growth of thyrotropic pituitary tumors in mice.
Cancer Res 16:171-174 (Feb.) 1956.
32. FURTH, J. AND CLIFTON, K. II.: Experimental pituitary tumors and the role of pituitary hormones in tumorigenesis of the breast and thyroid Cancer 10:842-853 (Jul-Aug.) 1957.
33. RAWSON, R, W. AND MONEY, W. L.: Comunicación personal (11 th. Post- Grad Assembly in Endocrinology and Metabolism, Endocrine Soc. San Francisco, No. 1959).
33a. MONEY, W. L., KUMAOKA, S., RAWSON, R. W. AND KROC,
R. L : Comparative effects of thyroxine analogues in experimental animals. Ann4 N. Y. Acad. of Sciencies 86:512-544 (Aprii) 1960
34. PIERCE, J, G., CARSTEN, M. E. AND WYNSTON, L. K.: Purification and chemistry of the thyroid stimulating hormone. Ann. N.Y. Acad. of Sciencies 86:612-624 (April) 1960. 35. PURVES, H. D. AND ADAMS, D.D.: Thyroid-stimulating hormone. Brit. Med. Bull. 16:128-132 (May) 1960.
36. WERNER, S. C., OTERO-RUIZ, E., BATES, R. W. AND SIEGEL.
B.: Neutralization of human serum pituitary thyrotropic fractions with antiesra to bovine pituitary Thyrotropin. Nature 185: 472-473 (Feb) 1960.
37. CLINE. M. J., SELENKO0, H. A. AND BOOKE, M. S.: Inhibition of thyrotropic activity by inniunologically specific an
tiserum. Endocrinology 67:273-276 (Aug.) 1960
38. HALMI. N. S.: Factors influencing the thyroidal iodine pump. Ciba Found. Coll. on Endocrinology. Vol 10, 1957. Pp. 79-96.
39. SONENBERG, M. AND MONEY, W. L.: Chemical derivatives of thyroid stimulating hormone preparations. Ann. N.Y. Acad.
of Sciences 86:625-646 (April) 1960.
40. SMITH, P.E. AND SMITII, L.P.: J. Med. Research 43:267, 1922. Citado por Purves & Adams (35).
41. BROWN, J. R.: The measurement of thyroid-stimulating hormone (TSH) in body bluids: a critical review. Acta Endocrinologica 32:289-309, 1959.
42. BAKKE. J. ... HEIDEMANN, L... LAWRENCE, N. AND WIDERG,
C. Endocrinology G1:252, 1957.
41b. D'ANGELO, S. A, AND GORDON, A. S. Endrocrinology 46-39, 1950.
41c. HENRY, 1:. AND BLOCITE-MICHEL. 1.: Ann. Endocr. Paris 16:258, 1955.
41d. QUERIDO, A., KASSENAAR. A. II. AND LAMEIJER, L.D.: Acta
Endo. Copenhagen 12:335. 1953.
41e. KRISS. J.P. AND GREENSPAN, F.S.: J. Clin. Endocr. & Me.
tab. 14:770, 1951.
41f. GILLILAND, IC. AND STRUDWICK, J.!.: Clin Science. 12:265 1953.
41g. ADAMS, D.D. AND PURVES, U. D: Endocrinology 57:17, 1955.
41h. McKENZIE, J.M.: Fderations Proceedings 16:17, 1957.
42. GREER. M.A. AND SHULL. II. T.: A quantitative study of the
effect of thyrotropin upon the thyroidal secretion rate in euthyroid and thyrotoxic subjects. J. Clin. Endocr. & Me
tab 07:1030-1099 (Sept.) 1957.
43. ADAMS, D.D.: The presence of an abnormal TSH in the serum of some thyrotoxic patients. J. Clin. Endocr. & Metab. 18:699 712 (July) 1958.
44. MCKENZIE, J. M.: Delaved thyroid response to serum from thyro-toxic patients. Endocrinology 62:863-868 (June) 1958.
45. ADAMS, D.D.. PURVES, II.D. AND SIRETT. N. E.. The response of hypophysectomized mice to injection of human serum ( thyroic stimulator. Endocrinology 68:154-155 (Jan.) 1961.
46. DOBYNS. B. M. AND WILSON, L.A.: An exophalamos-producing substance in the serum of patients suffering from progressive exophtalmos. J. Clin. Endocr. & Metab. 14:1392-1102 (Nov.) 1954.
47. WERNER. S.C.. HAMILTON. JI. AND NEMETIT, N.: Graves'disease: Hyperthyroidism or hyperpituitarism? J. Clin. Endocr. & Metab. 12:1561-1571 (Dec.) 1952.
48. A.W.G. Effect of thyrotropic hormone on the accumulation of radioative iodine in thyrotoxicosis. J. Clin. En
docr. & Metab. 19:1252-1257 (Oct.) 1959.
49. WERNER. S.C AND WELLINGTON, S.: Hyperthyroidism in a
patient with a pituitary chromophobe adenoma and a fragment of normal pituitary. J. Clin. Endocr. & Metab. 18:266-270 (March) 1958.
50. FAJANS, S: Hyperthyroidism in a a patient with post-partum necrosis of the pituitary: case report and implication. J. Clin. Endocr. & Metab. 18:271-277 (March) 1958.
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