Treatment of hypoparathyroidism with parathyroid hormone
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parathyroid hormone
PTH (1-34)
PTH (1-84)

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Cardona, E., Builes-Barrera, C. A., & Román-González, A. (2019). Treatment of hypoparathyroidism with parathyroid hormone. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 6(1), 35–41.


Hypoparathyroidism is an uncommon disorder of calcium metabolism. The main etiology is post-surgical in 75% of cases. Chronic hypoparathyroidism has an estimated prevalence of 2040 per 100,000 inhabitants. Clinical manifestations vary from asymptomatic to neuromuscular, neurological, cognitive, cardiac and decrease in quality of life. The standard treatment is calcium and calcitriol supplementation. Refractoriness to this therapeutic approach is frequent and is associated with a high incidence of adverse effects due to the high doses of supplements required. Until recently it was the only endocrine deficiency not treated with hormone replacement therapy. Recently the FDA has approved the use of recombinant PTH (1-84) for the treatment of refractory hypoparathyroidism. There are two PTH analogues available (PTH 1-84 and PTH 1-34). Both molecules have been associated with a decrease in the requirements of calcium and calcitriol supplementation, maintaining stable concentrations of serum calcium and phosphate, better quality of life and a more physiological bone metabolism with a low incidence of adverse effects. Currently hormone replacement therapy with PTH is not part of the routine treatment of hypoparathyroidism and has strict indications.
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