Tuberculosis y vitamina D: una relación intrigante

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Ramírez Ramos, C. F., Salamanca-Montilla, J. F., Correa, S., Torres-Restrepo, J. M., Ramírez-Méndez, D. A., Rivera-Marín, J. D., Pinzón-Tovar, A., & Lastra-González, G. (2019). Tuberculosis y vitamina D: una relación intrigante. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 6(2), 114–120.


La tuberculosis permanece como la enfermedad infecciosa que más muertes ha causado a lo largo de la historia de la existencia humana, sin poderse aún lograr su control. En años recientes ha emergido un cúmulo importante de evidencia clínica acerca de la función de la vitamina D (calcitriol o 1,25 hidroxivitamina D) en un papel que va más allá de la homeostasis del calcio. Su papel en el sistema inmunológico es muy interesante vinculando su déficit como un factor de riesgo contribuyente y así mismo fisiopatológico en un gran número de enfermedades autoinmunes e infecciosas. Dentro de éstas se destaca la tuberculosis, enfermedad endémica en nuestro país y en la cual el déficit de dicho compuesto (vitamina D) crea un factor de riesgo para desarrollar esta enfermedad en su forma activa.

Presentamos una revisión detallada de los estudios que explican el papel de la vitamina D en la susceptibilidad para el desarrollo de tuberculosis y los resultados de los estudios clínicos de suplencia de la misma publicados a la fecha.


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