Efficacy of two phosphodiesterase 5 inhibitors combined with ginkgo biloba in erectile dysfunction in men with chronic diseases
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erectile dysfunction
cronic disease

How to Cite

Espitia, F. J., & Orozco, L. (2019). Efficacy of two phosphodiesterase 5 inhibitors combined with ginkgo biloba in erectile dysfunction in men with chronic diseases. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 6(3), 155–163. https://doi.org/10.53853/encr.6.3.529


Objective: To compare the therapeutic efficacy of two selective inhibitors of 5-phosphodiesterase in combination with ginkgo biloba for the treatment of erectile dysfunction in men with chronic concomitant diseases.
Material and methods: Controlled, masked and randomized clinical trial; made between july 2013 and december 2016. Men older than 45 years with non-psychogenic erectile dysfunction in treatment for chronic diseases were included. The variables of primary interest were: international index of erectile function score, monthly coital frequency, time of drug response, percentage of satisfaction of the improvement of the dysfunction and adverse effects. Quantitative variables are presented as continuous variables through measures of central tendency and dispersion.
Results: 22 men were treated with tadalafil plus ginkgo biloba (group A) and 23 with vardenafil plus ginkgo biloba (group B); mean age 57.6 ± 8.4 years and 58.2 ± 7.8 for each group, respectively. The score of the initial international index of erectile function was 9.63 ± 1.26 (group A) and 10.35 ± 1.59 (group B); at the end of the study it was 21.78 ± 0.9 (group A), and 18.57 ± 0.3 (group B), p <0.015. At the end of the study, group A increased sexual activity from 2 sexual encounters per month to 9, while group B increased from 2 to 6, p <0.021.
Conclusions: The combination tadalafil plus ginkgo biloba has a satisfactory therapeutic efficacy on the improvement in the international index of erectile function score, favoring the monthly coital frequency, with time of onset of action and less adverse effects.

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