Hormonal and biochemical variables of bone mineral density and its correlation with young men obese and young men lean not-diabetic
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bone density

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Romero, M. C., Sierra, S. F., Rincón, J. D., Martínez, L. A., Pulido, J. C., Maldonado, L. M., Franco, R., Arteaga, J. M., Alzate, J. P., & Camino, J. E. (2019). Hormonal and biochemical variables of bone mineral density and its correlation with young men obese and young men lean not-diabetic. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 6(3), 178–186. https://doi.org/10.53853/encr.6.3.532


Introduction: Obesity has been associated with increased bone mineral density (BMD); however, recent studies report that it may lead to an increase in resorption and the risk of fracture.
Materials and methods: Analytical cross-sectional study that included men between 18 and 30 years old, in whom various hormonal measurements were taken (insulin, free and total testosterone, IGF-1, estradiol, leptin and adiponectin), biochemistry (PTOG-glucose, total cholesterol, HDL-C, LDL-C, RCP and HOMA-IR), anthropometric and others as body fat composition, BMD and bone mineral composition. The differences of the quantitative variables between obese and non-obese were evaluated by means of a T-student test or Wilcoxon test. To evaluate the correlation of BMD with the other variables, the Spearman correlation was used. Finally, a linear regression model is performed to predict BMD.
Results: This study included 34 obese and 35 non-obese individuals. In the non-obese group, an average of 1159 g (+/-0.08 g/cm2 ) of BMD was obtained compared to the group of obese men, with a mean of 1.311 g (+/-0.1 g/cm2 ) p = 0.001. It was found that BMD has a strong correlation with bone mineral content in the non-obese and moderate in the obese group. Adiponectin was negatively and moderately correlated in the obese group and weakly in the non-obese group. Finally, it was found that the presence of obesity, total fat, bone mineral content, basal insulin and HOMA-IR, significantly predict BMD in a linear regression model.
Conclusion: Both, BMD and bone mineral, content are higher in obese individuals compared to non-obese individuals, body mass index and variables such as insulin predict bone mineral density.

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