Keywords
covid-19
vitamin C
Antioxidant
vitamin C
Antioxidant
How to Cite
Mejia, L., & Alvarado, A. (2020). Vitamin C as antioxidant in SARS-CoV-2 management. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 7(2S), 99–101. https://doi.org/10.53853/encr.7.2S.593
Abstract
The current situation of pandemic generated by the new coronavirus SARS-CoV-2, by its morbid-mortality, has caused the scientific community to be implementing different treatment strategies for its management. This is the case of vitamin C, the main non-enzymatic antioxidant in plasma (1), which has been used for the prevention of respiratory infections and for the treatment of sepsis in critical patients. This article aims to review the evidence surrounding the role of vitamin C as a possible adjuvant in the management of patients with SARS-CoV-2 infection.
References
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8. Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, et al. Randomized, prospective trial of antioxidant supplementation in critically III surgical patients. Ann Surg. 2002;236(6):814-22. doi: 10.1097/00000658- 200212000-00014.
9. Zhujiang Hospital. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock (HYVCTTSSS) [Internet]. Disponible en: https://clinicaltrials.gov/ct2/show/NCT03258684.
10. National Cancer Institute. High-dose vitamin C (PDQ®) - Health Professional Version [Internet]. Disponible en: https://bit.ly/3dmOCsm.
11. Zhang M, Jativa DF. Vitamin C supplementation in the critically ill: A systematic review and meta-analysis. SAGE Open Med. 2018;6:2050312118807615. doi:10.1177/2050312118807615.
2. Kashiouris MG, L’Heureux M, Cable CA, Fisher BJ, Leichtle SW, Fowler AA. The Emerging Role of Vitamin C as a Treatment for Sepsis. Nutrients. 2020;12(2):292. doi:10.3390/nu12020292.
3. Marshall JC. Clinical trials of mediator-directed therapy in sepsis: What have we learned? Intensive Care Med. 2000;26(Suppl. 1):S75-S83. doi:10.1007/s001340051122.
4. Borrelli E, Roux-Lombard P, Grau GE, Girardin E, Ricou B, Dayer J, et al. Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk. Crit Care Med. 1996;24(3):392-7. doi: 10.1097/00003246- 199603000-00006.
5. Fowler AA, Truwit JD, Hite RD, Morris PE, DeWilde C, Priday A, et al. Effect of Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. JAMA. 2019;322(13):1261-70. doi: 10.1001/jama.2019.11825.
6. Erol A. High-dose intravenous vitamin C treatment for COVID-19 [Internet]. Disponible en: https://bit.ly/3coGczw.
7. Herna?ndez A, Papadakos PJ, Torres A, González DA, Vives M, Ferrando C, et al. Dos terapias conocidas podri?an ser efectivas como adyuvantes en el paciente cri?tico infectado por COVID-19. Rev Esp Anestesiol Reanim. 2020;67(5):245-52. doi: https://doi.org/10.1016/j.redar.2020.03.004. Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, et al. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015;350(6266):1391-6. doi:10.1126/science.aaa5004.
8. Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, et al. Randomized, prospective trial of antioxidant supplementation in critically III surgical patients. Ann Surg. 2002;236(6):814-22. doi: 10.1097/00000658- 200212000-00014.
9. Zhujiang Hospital. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock (HYVCTTSSS) [Internet]. Disponible en: https://clinicaltrials.gov/ct2/show/NCT03258684.
10. National Cancer Institute. High-dose vitamin C (PDQ®) - Health Professional Version [Internet]. Disponible en: https://bit.ly/3dmOCsm.
11. Zhang M, Jativa DF. Vitamin C supplementation in the critically ill: A systematic review and meta-analysis. SAGE Open Med. 2018;6:2050312118807615. doi:10.1177/2050312118807615.
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