Immunosenescence, multimorbidity, frailty and COVID-19
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Gutiérrez Cortes, W. A. . (2021). Immunosenescence, multimorbidity, frailty and COVID-19 . Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 8(1).


Objective. The COVID-19 pandemic has caused a significant increase in hospitalizations and deaths from pneumonia with multi-organ disease. Taking into account that older persons have been the most affected by the pandemic and that their high mortality is due to conditions typical of advanced age such as frailty, Multimorbidity, and Immunosenescence, the author intends to briefly describe these variables and their relationship with mortality.

Methods. A systematic search was carried out in databases such as PubMed and Scopus, based on articles on immunosenescence, multimorbidity, frailty, and COVID-19 in the last year. The high-frequency MeSH terms were used, the terms were: Coronavirus, COVID-19, Frailty, Immunosenescence, Multimorbidity, Sarcopenia. A total of 500 articles were obtained, they were filtered by date, age, language, and type of article, obtaining 50 articles for review.

Discussion. COVID-19 poses a great threat to older persons. This is particularly true in people with frailty and multimorbidity.

Conclusion. It is recognized that the pandemic will require permanent efforts in an uncertain time frame, which is why different authors have drawn attention to four objectives: first, to do more clinical research in older persons, second, to link geriatricians for decision making, third, knowledge of the needs of vulnerable populations, and fourth emphasize the importance of person-centered approaches that promote respect for autonomy, justice, and beneficence.
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