Frailty in elderly with diabetes: a narrative review
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frail elderly

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Morros-González, E. ., Vargas-Beltrán, M. P. ., Chacón-Valenzuela, E., Gómez, A. M., & Chavarro-Carvajal, D. (2022). Frailty in elderly with diabetes: a narrative review. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 8(4).


Context: The prevalence of older people with diabetes is relevant and frailty, as a reversible geriatric syndrome, has been related to different harmful health outcomes.
Objective: To describe the importance of the relationship between diabetes, frailty and the impact of comprehensive geriatric assessment in the management of older people with these conditions. In addition, describe tools for screening and diagnosis of frailty in older people with diabetes.
Methodology: A non-systematic search of the literature related to older people with
diabetes, frailty and the relationship between these conditions was carried out. Considering diabetes management guidelines and the frailty consensus.
Results: The management guidelines promote the multidimensional assessment of the elderly person with diabetes, seeking to guarantee comprehensive management
and adherence to it. Within the evaluation of the different domains, frailty as a geriatric syndrome becomes important to define the therapeutic objectives and goals, and there are different tools for its evaluation according to the level of care.
Conclusions: The diagnosis of frailty in older people with diabetes allows individualizing therapeutic management. We suggest using Frail as a screening questionnaire and the frailty phenotype criteria for its definitive diagnosis.
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Scheen A. Central nervous system: a conductor orchestrating metabolic regulations harmed by both hyperglycaemia and hypoglycaemia. Diabetes Metab. 2010;36 (supl. 3):S31-8. DOI:

Bunn F, Goodman C, Malone JR, Jones PR, Burton C, Rait G, et al. Managing diabetes in people with dementia: protocol for a realist review. Syst Rev. 2016;5(1):5. DOI:

Morley J, Vellas B, van Kan G, Anker S. Frailty consensus: a call to action. J Am. 2013;14(6):392-7. DOI:

Abizanda-Soler P, Rodríguez-Mañas L, editores. Tratado de Medicina Geriátrica. Madrid, España: Elsevier; 2020.

Gómez-Huelgas R, Gómez-Peralta F, Rodríguez L, Formiga F, Puig M, Mediavilla J, et al. Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano. Rev Esp Geriatr Gerontol. 2018;53(2):89-99. DOI:

Organización Panamericana de la Salud. División de promoción y protección de la salud. Encuesta Multicéntrica Salud Bienestar (SABE) en América Latina y Caribe. Washington: OPS; 2001.

Gómez F, Corchuelo J, Curcio CL, Calzada MT, Méndez F. SABE Colombia: survey on health, well-being, and aging in Colombia-study design and protocol. Curr Gerontol Geriatr Res. 2016. DOI:

Morros-González E, Borda MG, Reyes-Ortiz C, Chavarro-Carvajal D, Cano-Gutiérrez C. Anciano con diabetes y factores asociados. Acta Méd Colomb. 2017;42(4):230-6. DOI:

Gómez-Montes JF, Curcio-Borrero C, Henao GM. Fragilidad en ancianos Colombianos. Rev Med Sanitas. 2012;15(4):8-16.

Samper-Ternent R, Reyes-Ortiz C, Ottenbacher K, Cano CA. Frailty and sarcopenia in Bogotá: results from the SABE Bogotá Study. Aging Clin Exp Res. 2017;29(2):265-72. DOI:

Sinclair A, Dunning T, Rodriguez-Mañas L. Diabetes in older people: new insights and remaining challenges. Lancet Diabetes Endocrinol. 2014;3(4):275-85. DOI:

Morley J, Malmstrom TK, Rodriguez-Mañas L, Sinclair AJ. Frailty, Sarcopenia and Diabetes. J Am Med Dir Assoc. 2014;15(12):853-9. DOI:

Veronese N, Stubbs B, Fontana L, Trevisan C, Bolzetta F, De Rui M, et al. Frailty is associated with an increased risk of incident type 2 diabetes in the elderly. J Am Med Dir Assoc. 2016;17(10):902-7. DOI:

Howrey B, Al Snih S, Markides K, Ottenca. Frailty and Diabetes Among Mexican American Older Adults. Physiol Behav. 2011;176(1):139-48.

García-Esquinas E, Graciani A, Guallar-Castillón P, López-García E, Rodríguez-Mañas L, Rodríguez-Artalejo F. Diabetes and risk of frailty and its potential mechanisms: a prospective cohort study of older adults. J Am Med Dir Assoc. 2015 sept. 1;16(9):748-54. DOI:

Tobergte DR, Curtis S. Diagnóstico y tratamiento de diabetes mellitus en el anciano. J Chem Inf Model. 2013;53(9):1689-99.

Casals C, Casals-Sánchez JL, Suárez-Cadenas E, Aguilar-Trujillo MP, Estébanez-Carvajal FM, Vázquez-Sánchez MA. Fragilidad en el adulto mayor con diabetes mellitus tipo 2 y su relación con el control glucémico, perfil lipídico, tensión arterial, equilibrio, grado de discapacidad y estado nutricional. Nutr Hosp. 2018;35(4):820-6. DOI:

Sinclair AJ, Rodríguez-Mañas L. Diabetes and Frailty: Two Converging Conditions? Can J Diabetes. 2016;40(1):77-83. DOI:

Chao C, Wang J, Chien KL, COhort of GEriatric Nephrology in NTUH (COGENT) study group. Both pre-frailty and frailty increase healthcare utilization and adverse health outcomes in patients with type 2 diabetes mellitus 11 Medical and Health Sciences 1103 Clinical Sciences. Cardiovasc Diabetol. 2018;17(1):1-13. DOI:

van den Beld AW, Kaufman JM, Zillikens C, Lamberts S, Egan J, van der Lely A. The physiology of endocrine systems with ageing HHS Public Access. Lancet Diabetes Endocrinol. 2018;6(8):647-58. DOI:

Sawlani S, Saini R, Vuppuluri R, Rojas L, Patel M, Patel P, et al. Endocrine Changes with Aging. Endocrinol Int J. 2016;3(6):133-43.

Navarrete-Reyes AP, Ávila-Funes JA. Diabetes mellitus y el síndrome de fragilidad en el anciano. Rev Investig Clin. 2010;62(4):327-32.

Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, et al. Frailty in older adults: Evidence for a phenotype. J Gerontol Med Sci. 2001;56(3):146-64. DOI:

Rockwood K, Stadnyk K, MacKnight C, McDowell I, Hebert R, Hogan DB. A brief clinical instrument to classify frailty in elderly people. Lancet. 1999;353:205-6. DOI:

Rockwood K, Song X, MacKnight C, Bergman H, Hogan D, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. Can Med Assoc J. 2005;173(5):489-95. DOI:

Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med. 2011;27(1):17-26. DOI:

Rolfson D, Majumdar S, Tsuyuki R, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing. 2006;35(5):526-9. DOI:

Abellan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A. task force on frailty assessment of older people in clinical practice. J Nutr Heal Aging. 2008;12(1):29-37. DOI:

Abellan G, Rolland YM, Morley JE, Vellas B. Frailty: toward a clinical definition. J Am Med Dir Assoc. 2008;9(2):71-2. DOI:

Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged african americans. J Nutr Heal Aging. 2012;16(7):601-8. DOI:

Li JJ, Jiang S, Zhu ML, Liu X, Sun X, Zhao SQ. Comparison of Three Frailty Scales for Prediction of Adverse Outcomes Among Older Adults: A Prospective Cohort Study. J Nutr Heal Aging. 2021;25(4):419-24. DOI:

Gómez JF, Curcio CL, Alvarado B, Zunzunegui MV, Guralnik J. Validity and reliability of the Short Physical Performance Battery (SPPB): a pilot study onrmobility in the Colombian Andes. Colomb Med. 2013;44(3):165-71. DOI:

Wennie-Huang WN, Perera S, Vanswearingen J, Studenski S. Performance measures predict onset of activity of daily living difficulty in community-dwelling older adults. J Am Geriatr Soc. 2010;58(5):844-52. DOI:

Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;332(9):556-62. DOI:

Leroith D, Biessels GJ, Braithwaite SS, Casanueva FF, Draznin B, Halter JB, et al. Treatment of Diabetes in Older Adults: An Endocrine Society. J Clin Endocrinol Metab. 2019;104:1520-74. DOI:

American Diabetes Association. Older Adults: Standards of Medical Care in Diabetes - 2021. Diabetes Care. 2021;44(supl. 1):S168-79. DOI:

Dent E, Morley JE, Cruz-Jentoft AJ, Woodhouse L, Rodriguez-Mañas L, Fried L, et al. Physical frailty: ICFSR International Clinical Practice Guidelines for identification and management. J nutr Heal Aging. 2019;23(9):771-87. DOI:

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