GLP1 analogs: Blazing new trails in diabetes management
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Keywords

GLP1
diabetes

How to Cite

Casas Figueroa, L. A. (2022). GLP1 analogs: Blazing new trails in diabetes management. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 9(2). https://doi.org/10.53853/encr.9.2.754

Abstract

In the early 1900s (1902), researchers Bayliss and Starling described that pancreatic secretions were produced by chemical stimuli as well as neural stimuli, and that secretions coming from the intestine contained "something" that was released into the circulation and had the ability to stimulate pancreatic secretions, the first hormone being named secretin. These findings contributed to the understanding that there are key interactions between hormones and the nervous system, which are necessary for gastrointestinal functions. A few years later these hormones were considered to contribute to glucose regulation in diabetic patients, supported by Barre's experiments, and the effect of incretin, given by gastrointestinal hormones after oral glucose loading, was later clarified by research published by Perley and Kipnis. In 1983 a glucagon-like peptide (GLP-1) was isolated from the intestine and found to stimulate insulin secretion and inhibit glucagon secretion, as well as inhibitory effects on food intake and gastric emptying, which prompted the development of GLP-1-based treatments.

https://doi.org/10.53853/encr.9.2.754
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References

Bayliss WM, Starling EH. The mechanism of pancreatic secretion. J Physiol. 1902 sept. 12;28(5):325-53. https://doi.org/10.1113/jphysiol.1902.sp000920

Zuns E, La Barre J. Contributions a l’étude des variations physiologiques de la sécrétion interne du pancréas relations entre les sécrétions externe et interne du pancréas. Arch Intern Physiol. 1929;31:20-44. https://doi.org/10.1080/13813455.1929.11864670

Perley J, Kipnis DM. Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects. J. Clin Invest. 1967 dic.;46(12):1954-62. https://doi.org/10.1172/JCI105685

Bell GI, Santerre DF, Mullenbach GT. Hamster preproglucagon contains sequence of glucagon and two related peptides. Nature. 1983;302:716-8. https://doi.org/10.1038/302716a0

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Cantor-Cruz F, Gómez-Gómez O, Mendivelso-Duarte F, Ruiz PC, Rincón-Sierra O, Yama-Mosquera E, et al. GLP-1RA en el manejo de diabetes mellitus tipo 2: una validación de revisiones sistemáticas. Rev Colomb Endocrinol Diabet Metab. 2022;9(2). https://doi.org/10.53853/encr.9.2.601

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