David Marine, the pathologist that led endemic goiter global eradication
PDF (Español (España))
xhtml (Español (España))


Endemic goiter
iodized salt
David Marine
thyroid diseases
Akron Ohio
World Health Organization
History of Endocrinology

How to Cite

Jácome Roca , A. . (2022). David Marine, the pathologist that led endemic goiter global eradication. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 9(4). https://doi.org/10.53853/encr.9.4.768


Objective: This narrative review describes the studies of David Marine, showing the importance of supplying adequate daily doses of iodine mixed with salt as a vehicle, for the prevention of endemic goiter.

Contents: This paper describes the life and achievements of the American pathologist David Marine (1880-1976), remembered for a well-designed successful clinical study, that -with the help of his assistant O.P. Kimball-showed the good effect of iodine given to a large group of female students on thecity of Akron, Ohio, from 1917 to 1922. Goiter was greatly reduced in the population studied.

Contributions: His studies stimulated the development of the current program of universal consumption of iodized salt aimed to eradicate endemic goiter. This program was projected in 1960 by the World Health Organization.

PDF (Español (España))
xhtml (Español (España))


Jácome-Roca A. La revolución del yodo en el siglo XIX. Rev Colomb Endocrinol Diab Metab. 2021;8(2):105-14. https://doi.org/10.53853/encr.8.2.707

Swain PA. Bernard Courtois (1777-1838), famed for discovering iodine (1811), and his life in Paris from 1798. Hist Chem. 2005;30(2):103-11.

Ucrós-Cuéllar A. Historia de la endocrinología en Colombia. Asociación Colombiana de Endocrinología, Diabetes y Metabolismo, Bogotá; 2000.

Coindet JF. Nouvelles recherches sur les effets de l'iode et sur. les pre?cautions a? suivre dans le traitement du goi?tre par ce nouveau reme?de. Ann Chim Phys. 1821;16(2):345-56.

Jácome-Roca A. Historia de los Medicamentos. De hierbas, remedios, fórmulas secretas y fármacos. España: OmniScriptum Publishing Books. Mauricio; 2017.

Amaro-Méndez S. Breve Historia de la Endocrinología. La Habana, Cuba: Editorial Científico Técnica; 1975.

Jácome-Roca A. Historia de las Hormonas. Bogotá: Academia Nacional de Medicina; 2008.

Medvei VC. A history of endocrinology. Inglaterra: Falcon House; 1982.

Zimmerman MB. Research on Iodine Deficiency and Goiter in the 19th and Early 20th Centuries. J Nutr. 2008;138(11):2060-3. https://doi.org/10.1093/jn/138.11.2060

Kohn LA. The midwestern American “epidemic” of iodine-induced hyperthyroidism in the 1920s. Bull NY Acad Med. 1976;52:770-81.

Burgi H, Kohler M, Morselli B. Thyrotoxicosis incidence in Switzerland and benefit of improved iodine supply. Lancet. 1998;352(9133):1034. https://doi.org/10.1016/S0140-6736(05)60076-1

Selz B. Iodine deficiency disease in Switzerland one hundred years after Theodor Kocher's survey: a historical review with some new goiter prevalence data. Acta Endocrinol (Copenh). 1990;(6):577-90. https://doi.org/10.1530/acta.0.1230577

Carpenter KJ. David Marine and the Problem of Goiter. J Nutr. 2005;135(4):675-80. https://doi.org/10.1093/jn/135.4.675

Matovinovic J. David Marine (1880-1976): Nestor of Thyroidology. Perspect Biol Med. 1978;21:565-89. https://doi.org/10.1353/pbm.1978.0035

Marine D. On the occurrence and physiological nature of glandular hyperplasia of the thyroid (dog and sheep), together with remarks on important clinical (human) problems. Johns Hopkins Bull. 1907;18:359-65.

Marine D. Further observations and experiments on goitre (so called thyroid carcinoma) in brook trout (Salvelinus fontinalis). J Exp Med. 1914;19:70-88. https://doi.org/10.1084/jem.19.1.70

Marine D, Williams WW. The relation of iodine to the structure of the thyroid gland. Arch Intern Med. 1908;1:349-84. https://doi.org/10.1001/archinte.1908.00050030002001

Marine D, Kimball OP. The prevention of simple goiter in man. J Lab Clin Med. 1917;3:40-8.

Kimball OP. The prevention of goiter in Detroit and Cleveland. J Am Med Assoc. 1931;97:1877-9. https://doi.org/10.1001/jama.1931.02730250035011

Marine D, Baumann EJ, Spence AW, Cipra A. Further studies on the etiology of goiter with particular reference to the action of cyanides. Proc Soc Exp Biol Med. 1932;29:772-7. https://doi.org/10.3181/00379727-29-6073

Bu?rgi H. Establishing the iodine content of salt through trial and error: lessons from the 80 year-old Swiss iodized salt program. IDD Newsletter. 2005;21:11-4.

Kevany J, Fierro-Benitez R, Pretelt E, Stanbury J. Prophylaxis and Treatment of Endemic Goiter with Iodized Oil in Rural Ecuador and Perú. Amer J Clin Nutr. 1969;22(12):1597-1607. https://doi.org/10.1093/ajcn/22.12.1597

Hetzel BS. Iodine deficiency disorders (IDD) and their eradication Lancet.1983;2:1126-9. https://doi.org/10.1016/S0140-6736(83)90636-0

Jácome-Roca A. Trastornos por deficiencia de Yodo. Programa de yodización en Colombia y América Latina. Medicina. 2001;23(2):100-4.

Rueda-Williamson R, Pardo F, Piedrahita F, Ariza J, Uribe L. La efectividad de la yodación de la sal en la prevención del bocio endémico en Colombia. Arch Latinoamer Nutr 1966;16(1):65-88.

Vargas-Uricoechea H, Bastidas-Sánchez B, Perdomo-Cabrera M, Vargas-Sierra H. Estado Nutricional del Yodo. Medicina. 2015;37(2):122-139. https://revistamedicina.net/ojsanm/index.php/Medicina/article/view/109-3

Paredes-Suárez M. Aspectos Históricos de la deficiencia de Yodo en América. Medicina. 2001;23(2):124-34. https://revistamedicina.net/ojsanm/index.php/Medicina/article/view/56-10

Vargas-Uricoechea H, Sierra-Torres CH, Holguín-Betancourt CM, Cristancho-Torres L. Trastornos Asociados a la Deficiencia de Yodo. Vigilancia permanente es deficitaria en zonas vulnerables. Medicina. 2012;34(2):119-45. https://revistamedicina.net/ojsanm/index.php/Medicina/article/view/97-4

Vargas-Uricoechea H, Pinzón-Fernández MV, Bastidas-Sánchez BE. Historia del bocio endémico, desde Sheng-Nung hasta los programas de yodación universal de la sal en Latinoamérica. Rev CES Med. 2018;32(2):167-77. https://doi.org/10.21615/cesmedicina.32.2.10

Patiño-Restrepo JF. Revisión Histórica sobre el bocio en Suramérica y la Nueva Granada. Medicina. 2001;23(2):135-50. https://revistamedicina.net/ojsanm/index.php/Medicina/article/view/56-11

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2022 Revista Colombiana de Endocrinología, Diabetes & Metabolismo




Download data is not yet available.