Semaglutide in diabetic kidney disease: Experience in two kidney health programs in Colombia
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Keywords

Type 2 Diabetes Mellitus
Kidney Chronic Disease
albuminuria
Glucagon-Like Peptide 1 (MeSH)

How to Cite

Daza-Arnedo, R. ., Rico-Fontalvo, J., Raad-Sarabia, M., Ramos-Clason, E., Bohórquez-Rivero, J. ., Montejo-Hernández, J., Cabrales-Juan, J., Escobar-Pacheco, C., Acosta-Pérez, T., Henao-Ramirez, C., Cardona-Blanco, M., & Martinez-Avila, M. (2022). Semaglutide in diabetic kidney disease: Experience in two kidney health programs in Colombia. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 9(3). https://doi.org/10.53853/encr.9.3.776

Abstract

Background: Semaglutide has shown renal benefits in previous studies; however, its efficacy and safety in patients with diabetic kidney disease in the Latin American population have been poorly studied.

Purpose: To detail the clinical results and to evaluate the glycemic and renal efficacy and safety of semaglutide in patients with DKD during 6 months of follow-up.

Materials and methods: Retrospective observational study that included patients with type 2 diabetes mellitus (DM2) and renal compromise, with glycated hemoglobin (HbA1c) between 7.5-10%, treated with subcutaneous semaglutide for 6 months.

Results: 30 patients, age (63-75 years), 60% Women. Duration of DM2: 10 years and median baseline HbA1c 8.3% (7.5-10%), occasional urine albuminuria/creatinuria ratio (RAC) 76.6 mg/g (8.8-670 mg/g), creatinine 1, 5 mg/dl (0.85 - 1.87 mg/dl), estimated glomerular filtration rate (eGFR) 43.5 ml/min (28.0 -94.0 ml/min). Statistical significance was found in the decrease in HbA1c with a median at 3 months of 7.2% (IQR: 6.5 - 7.9) and at 6 months of 6.8% (IQR: 6.3 - 7.4), p=0.0040. In the subgroup analysis, in patients with albuminuria A3=816 mg/g (612 - 1670), a statistically significant decrease was observed with a median of 754 mg/g at 3 months (IQR: 514 - 1450) and at 6 months of 310mg/g (IQR: 258-340), p=0.0060. We did not obtain statistically significant results in terms of improvement in blood pressure (BP), weight, and lipid control.

Conclusion: In real-life clinical practice, semaglutide proved to be an effective and safe drug for adequate glycemic control in patients with diabetic kidney disease, also demonstrating a reduction in albuminuria in patients with category A3.

https://doi.org/10.53853/encr.9.3.776
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