Pathophysiology and mechanisms of action of exercise in the management of type 2 diabetes mellitus
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Diabetes Mellitus Type 2
Insulin Resistance
Physical Exercise
Skeletal Muscle
Adipose Tissue
Strength Training

How to Cite

León-Ariza, H. H., Rojas Guardela, M. J., & Coy Barrera, A. F. . (2023). Pathophysiology and mechanisms of action of exercise in the management of type 2 diabetes mellitus. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 10(2).


Background: Currently, the type 2 diabetes mellitus (T2D) is a highly prevalent disease in the world that is characterized by the inability to regulate plasma glucose and involves several phases for its development, including insulin resistance and dysfunction of pancreatic beta cells. The biological mechanisms that lead to the development of the disease involve intracellular alterations in organs such as skeletal muscle, where, triggered by lipotoxicity and glucotoxicity, they condition the development of insulin resistance; and the presence of these same alterations in beta cells that results in reduced insulin production.

Purpose: Understand the biological mechanisms of how exercise prevents aids in the management of type 2 Diabetes Mellitus.

Methodology: Electronic articles from databases from the last ten years as well as Endocrinology and Exercise Physiology text guides in relation to type 2 diabetes mellitus and exercise were reviewed

Results: Both, strength and endurance physical exercise have shown to improve muscle metabolic activity, reduce systemic inflammation, promote mitochondrial function, modify body composition, and contribute to beta cell function. Apparently, part of these effects are secondary to the endocrine action of the muscle, but also to the metabolic and energetic impact that exercise has.

Conclusions: This review demonstrates the biological mechanism in which the exercise is a key pillar for the prevention and treatment of T2DM.
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