Abstract
Introduction: Graves' disease is associated with Periodic Hypokalemic Paralysis (PPHC). Given the interesting particularities of this association in medical practice and learning, we have shared the present case.
Purpose: To report the clinical and laboratory findings of a patient who presented with generalized weakness secondary to PPHC as the debut of Graves' disease, without other manifestations of thyrotoxicosis.
Case presentation: A 44-year-old male patient consulted the emergency department for flaccid quadriparesis, previously self-medicated with dexamethasone for lower back pain. Serum potassium of 1.9 mmol/L, TSH level < 0.005 ?UI/mL, positive antiTRAb, and diffuse hypercapillary goiter. PPHC secondary to Graves’ disease was diagnosed. The patient improved with hydroelectrolyte replacement and use of Beta blockers and antithyroid drugs.
Discussion: Hyperthyroidism is associated with multiple systemic manifestations, such as PPHC, which, despite being an infrequent finding in Graves' disease, was the only clinical manifestation in the patient. Patients with PPHC rarely present with paralysis and no signs of hyperthyroidism. However, the exact mechanism of action of PPHC in thyrotoxicosis remains unclear. In this case, it is hypothesized that self-medication with steroids may have worsened the hypokalemia.
Conclusion: Although infrequent, PPHC causes generalized weakness. A high index of clinical suspicion is key to the timely ordering of electrolytes, along with the systematic search for diseases that are associated with hypokalemia and weakness, such as Graves' disease.
References
Lin SH, Huang CL. Mechanism of thyrotoxic periodic paralysis. J Am Soc Nephrol. 2012;23(6):985-8. https://doi.org/10.1681/ASN.2012010046
Chaudhry MA, Wayangankar S. Thyrotoxic periodic paralysis: a concise review of the literature. Curr Rheumatol Rev. 2016 oct. 20;12(3):190-4. https://doi.org/10.2174/1573397112666160404124822
Kung AW. Clinical review: thyrotoxic periodic paralysis: a diagnostic challenge. J Clin Endocrinol Metabol. 2006;91(7):2490-5. https://doi.org/10.1210/jc.2006-0356
Chan A, Shinde R, Chow CC, Cockram CS, Swaminathan R. In vivo and in vitro sodium pump activity in subjects with thyrotoxic periodic paralysis. BMJ. 1991 nov. 2;303(6810):1096-9. https://doi.org/10.1136/bmj.303.6810.1096
Chan A, Shinde R, Chow CC, Cockram CS, Swaminathan R. Hyperinsulinaemia and Na + , K + -ATPase activity in thyrotoxic periodic paralysis. Clin Endocrinol. 1994 ag.;41(2):213-6. https://doi.org/10.1111/j.1365-2265.1994.tb02532.x
Schalin-Jäntti C, Laine T, Valli-Jaakola K, Lönnqvist T, Kontula K, Välimäki MJ. Manifestation, management and molecular analysis of candidate genes in two rare cases of thyrotoxic hypokalemic periodic paralysis. Horm Res. 2005;63(3):139-44. https://doi.org/10.1159/000084689
Ryan DP, Dias da Silva MR, Soong TW, Fontaine B, Donaldson MR, Kung AW, et al. Mutations in potassium channel kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis. Cell. 2010 en.;140(1):88-98. https://doi.org/10.1016/j.cell.2009.12.024
Guerra M, Rodriguez Del Castillo A, Battaner E, Mas M. Androgens stimulate preoptic area Na+,K+-ATPase activity in male rats. Neurosci Lett. 1987 jul.;78(1):97-100. https://doi.org/10.1016/0304-3940(87)90568-4
Kurihara K, Maruyama S, Hosoi K, Sato S, Ueha T, Gresik EW. Regulation of Na+,K+-ATPase in submandibular glands of hypophysectomized male mice by steroid and thyroid hormones. J Histochem Cytochem. 1996 jul. 3;44(7):703-11. https://doi.org/10.1177/44.7.8675991
Polamaung W, Kongkit J, Yimnoi P, Boonchaya-Anant P, Snabboon T. Thyrotoxic hypokalemic periodic paralysis triggered by dexamethasone administration. Acta Med. 2020;63(2):91-3. https://doi.org/10.14712/18059694.2020.24
Trzepacz PT, Klein I, Roberts M, Greenhouse J, Levey GS. Graves’ disease: an analysis of thyroid hormone levels and hyperthyroid signs and symptoms. Am J Med. 1989 nov.;87(5):558-61. https://doi.org/10.1016/S0002-9343(89)80614-X
Nordyke RA. Graves’ disease. Influence of age on clinical findings. Arch Intern Med. 1988 mzo. 1;148(3):626-31. https://doi.org/10.1001/archinte.148.3.626
Manoukian MA, Foote JA, Crapo LM. Clinical and metabolic features of thyrotoxic periodic paralysis in 24 episodes. Arch Intern Med. 1999 mzo. 22;159(6):601. https://doi.org/10.1001/archinte.159.6.601
Ladino-Malagón LD, Uribe-Uribe CS, Pérez-Villegas DP. Parálisis periódica hipocaliémica tirotóxica revisión de literatura: a propósito de tres casos. Arch Neurocien. 2012;17(1):25-33.
Ludwing J, Sanabria A. Parálisis periódica tirotóxica. Acta Med Colomb. 2011;36(3).
Cogollo González M, Julio Narváez LC, Alvarado Cueto DE. Parálisis periódica hipocalémica tirotóxica. Acta Colomb Cuid Intensivo. 2016;16(2):102-5. https://doi.org/10.1016/j.acci.2015.12.002
Orjuela JE, Abarca LC, Gómez BH, Ocampo Posada M, Garcés Villabón L. Parálisis periódica hipocalémica tirotóxica. Repert Med Circ. 2022;31(3):283-7.
Moreno-Rozo NK, Rosero-Arellano CH, García-Castaño S. Parálisis periódica hipopotasémica tirotóxica: reporte de caso y revisión del tema. Medicina & Laboratorio. 2020;24(3):245-54.
Pinzón A, Vásquez N. Parálisis periódica hipocalémica tirotóxica. Rev Med. 2014;22(1):68-72. https://doi.org/10.18359/rmed.1032
Hoyos K, Arenas LD, Jerez KA. Debut de hipertiroidismo con parálisis periódica hipopotasiémica, una presentación poco convencional. Rev Colomb Endocrinol Diabet Metab. 2018;5(2).
Acevedo Rueda SM, Rincón Albarrán LA. Parálisis periódica hipocalémica tirotóxica. Med UNAB. 2013;16(1):39-44. https://doi.org/10.29375/01237047.1763
Siddamreddy S, Dandu VH. Thyrotoxic Periodic Paralysis. 2023 Jul 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.
Cesur M, Bayram F, Temel MA, Ozkaya M, Kocer A, Ertorer ME, et al. Thyrotoxic hypokalaemic periodic paralysis in a Turkish population: three new case reports and analysis of the case series. Clin Endocrinol. 2008 en.;68(1):143-52. https://doi.org/10.1111/j.1365-2265.2007.03014.x
Nicoloff JT, Fisher DA, Appleman MD. The role of glucocorticoids in the regulation of thyroid function in man. J Clin Invest. 1970 oct.;49(10):1922-9. https://doi.org/10.1172/JCI106411
Tai HT, Lee PT, Ou SH. Steroid-induced hypokalemic periodic paralysis: a case report and literature review. BMC Nephrol. 2023 mzo. 24;24(1):70. https://doi.org/10.1186/s12882-023-03131-3
Jácome Roca A. Tratado de Tiroides. Rev Colomb Endocrinol Diabet Metab. 2015;2(1):58. https://doi.org/10.53853/encr.2.1.74
Vargas-Uricoechea H, Sierra-Torres CH, Meza-Cabrera IA. Enfermedad de Graves-Basedow: fisiopatología y diagnóstico. Medicina. 2013;35(1):41-66.
Kralem Z, Baron E, Kahana L, Sadeh O, Shelnfeld M. Changes in stimulating and blocking TSH receptor antibodies in a patient undergoing three cycles of transition from hypo to hyper-thyroidism and back to hypothyroidism. Clin Endocrinol. 1992 febr.;36(2):211-4. https://doi.org/10.1111/j.1365-2265.1992.tb00960.x
Takasu N, Yamada T, Sato A, Nakagawa M, Komiya I, Nagasawa Y, et al. Graves’ disease following hypothyroidism due to hashimoto’s disease: studies of eight cases. Clin Endocrinol. 1990 dic.;33(6):687-98. https://doi.org/10.1111/j.1365-2265.1990.tb03906.x
Tamai H, Kasagi K, Takaichi Y, Takamatsu J, Komaki G, Matsubayashi S, et al. Development of spontaneous hypothyroidism in patients with graves 5 disease treated with antithyroidal drugs: clinical, immunological, and histological findings in 26 patients. J Clin Endocrinol Metabol. 1989;69(1):49-53. https://doi.org/10.1210/jcem-69-1-49
Lu KC, Hsu YJ, Chiu JS, Hsu YD, Lin SH. Effects of potassium supplementation on the recovery of thyrotoxic periodic paralysis. Am J Emerg Med. 2004;22(7):544-7. https://doi.org/10.1016/j.ajem.2004.09.016
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2024 Revista Colombiana de Endocrinología, Diabetes & Metabolismo