Keywords
Metabolic syndrome
Post-COVID-19 syndrome
Diabetes
Hypertension
Dyslipidemia
Obesity
How to Cite
Abstract
Background: Metabolic syndrome (MS) is defined as a set of risk factors that increase the likelihood of cardiovascular disease. Post-COVID syndrome is a long-term complication of COVID-19 infection defined by the WHO as the perpetuation of acute disease symptoms beyond 12 weeks with no other apparent cause. The association between cardiometabolic diseases and complications of acute SARS-CoV 2 infection has been clear from the beginning, but this is not the case with post-COVID syndrome.
Purpose: To determine the association between the presence of cardiovascular diseases at the time of acute SARS-CoV-2 infection and the development of post-COVID syndrome.
Methods: Observational, cohort, retrospective study with a total of 278 patients, 140 in the exposed cohort and 138 in the unexposed cohort, to establish the association between the presence of cardiovascular diseases in the acute phase of COVID-19 infection and post-COVID syndrome.
Results: In the exposed cohort, 74.1% presented post-COVID syndrome, while in the unexposed cohort, 25.9% presented this outcome. After multivariate analysis, a statistically significant association was established between the diagnosis of metabolic syndrome in the acute phase of COVID-19 infection and the development of post-COVID syndrome with an RRa 3.18, 95% CI 1.42-7.14 p 0.005.
Conclusions: A clear association was established between the presence of metabolic syndrome in the acute phase of COVID-19 infection and the appearance of post-COVID syndrome.
References
Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5-6):231-7. https://doi.org/10.1242/dmm.001180
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143-421.
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation. 2005;112(17):2735-52. https://doi.org/10.1161/circulationaha.105.169404
Pájaro-Galvis N, Abuabara-Franco E, Leal-Martínez V, Serpa-Díaz D, Rico-Fontalvo J, Daza-Arnedo R, et al. Anticoagulación en pacientes con infección por COVID-19. Salud UIS. 2020;52(4):422-30. https://doi.org/10.18273/revsal.v52n4-2020009
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-20. https://doi.org/10.1056/nejmoa2002032
Datta SD, Talwar A, Lee JT. A proposed framework and timeline of the spectrum of disease due to SARS-CoV-2 infection: illness beyond acute infection and public health implications. JAMA. 2020;324(22):2251-2.
Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV, WHO Clinical Case Definition Working Group on Post-COVID-19 Condition. A clinical case definition of post COVID-19 condition by a Delphi consensus. Lancet Infect Dis. 2022;22(4):e102-7. https://doi.org/10.1016/s1473-3099(21)00703-9
Pavli A, Theodoridou M, Maltezou H. Post-COVID syndrome: incidence, clinical spectrum, and challenges for primary healthcare professionals. Arch Med Res. 2021;52(6):575-81. https://doi.org/10.1016/j.arcmed.2021.03.010
Baquero Rodríguez R, Yomayusa N, González C, Yama E, Vargas JG, Rico J, et al. Consenso colombiano de expertos sobre recomendaciones informadas en la evidencia para la prevención, diagnóstico y manejo de la infección por SARS-CoV-2/COVID-19 en paciente pediátrico con enfermedad renal crónica o lesión renal aguda asociada a COVID-19. Rev. Colomb. Nefrol. 2020;7(2)50-69. https://doi.org/10.22265/acnef.7.Supl.2.488
Salamanna F, Veronesi F, Martini L, Landini MP, Fini M. Post-COVID-19 syndrome: the persistent symptoms at the post-viral stage of the disease: a systematic review of the current data. Front Med. 2021;8:653516. https://doi.org/10.3389/fmed.2021.653516
Maltezou HC, Pavli A, Tsakris A. Post-COVID syndrome: an insight on its pathogenesis. Vaccines. 2021;9(5):497. https://doi.org/10.3390%2Fvaccines9050497
Fériz-Bonelo KM, Iriarte-Durán MB, Giraldo O, Parra-Lara LG, Martínez V, Urbano MA, et al. Diabetes and stress hyperglycemia in SARS-CoV-2 infection. Biomédica. 2024;44(supl. 1):73-88. https://doi.org/10.7705/biomedica.7095
Lopera Vargas JM, Rico Fontalvo JE, Melgarejo E, Castillo Barrios GA, Ramírez Rincón A, Gómez AM, et al. Efecto de terapias farmacológicas para el control glicémico en pacientes con diabetes mellitus tipo 2 en los desenlaces vasculares. Rev Colom Nefrol. 2020;7(1):44-59. https://doi.org/10.22265/acnef.7.1.372
Gonzalez C, Yama E, Yomayusa N, Vargas J, Rico J, Ariza A, et al. Consenso colombiano de expertos sobre recomendaciones informadas en la evidencia para la prevención, diagnóstico y manejo de la lesión renal aguda por SARS-CoV-2/COVID-19. Rev Colom Nefrol. 2020;7(supl. 2). https://doi.org/10.22265/acnef.7.supl.2.73
Aroca-Martínez G, Avendaño-Echavez L, Garcia C, Ripoll D, Dianda D, Cadena-Bonfanti A, et al. Renal tubular dysfunction in COVID-19 patients. Ir J Med Sci. 2023;192(2):923-7. https://doi.org/10.1007%2Fs11845-022-02993-0
Klok FA, Boon GJ, Barco S, Endres M, Miranda Geelhoed JJ, Knauss S, et al. The post-COVID-19 functional status scale: a tool to measure functional status over time after COVID-19. Eur Respir J. 2020;56(1):2001494.
Hosmer DW, Taber S, Lemeshow S. The importance of assessing the fit of logistic regression models: a case study. Am J Public Health. 1991;81(12):1630-5. https://doi.org/10.2105/ajph.81.12.1630
Bastos LS, de Vasconcellos Carvalhaes de Oliveira R, de Souza Velasque L. Obtaining adjusted prevalence ratios from logistic regression models in cross-sectional studies. Cad Saude Publica. 2015;31(3):487-95.
AlRasheed MM, Al-Aqeel S, Aboheimed GI, AlRasheed NM, Abanmy NO, Alhamid GA, et al. Quality of life, fatigue, and physical symptoms poscovid condition: a cross-sectional comparative study. Healthcare. 2023;11(11):1660. https://doi.org/10.3390/healthcare11111660
Loosen SH, Ole Jensen BE, Tanislav C, Luedde T, Roderburg C, Kostev K. Obesity and lipid metabolism disorders determine the risk for development of long COVID syndrome: a cross-sectional study from 50,402 COVID-19 patients. Infection. 2022;50(5):1165-70. https://doi.org/10.1007/s15010-022-01784-0
Fernández-de-las-Peñas C, Torres-Macho J, Elvira-Martínez CM, Molina-Trigueros LJ, Sebastián-Viana T, Hernández-Barrera V. Obesity is associated with a greater number of long-term poscovid symptoms and poor sleep quality: a multicentre case-control study. Int J Clin Pract. 2021;75(12):e14917. https://doi.org/10.1111/ijcp.14917
Vimercati L, De Maria L, Quarato M, Caputi A, Gesualdo L, Migliore G, et al. Association between long COVID and overweight/obesity. J Clin Med. 2021;10(18):4143. https://doi.org/10.3390/jcm10184143
Fernández-de-las-Penas C, Guijarro C, Torres-Macho J, Velasco-Arribas M, Plaza-Canteli S, Hernández-Barrera V, et al. Diabetes and the risk of long-term poscovid symptoms. Diabetes. 2021;70(12):2917-21. https://doi.org/10.2337/db21-0329
Augustin M, Schommers P, Stecher M, Dewald F, Gieselmann L, Gruell H, et al. Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study. Lancet Reg Health Eur. 2021;6:100122. https://doi.org/10.1016/j.lanepe.2021.100122
Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, et al. Attributes and predictors of long COVID. Nat Med. 2021;27(4):626-31. https://doi.org/10.1038/s41591-021-01292-y
Alkodaymi MS, Omrani OA, Fawzy NA, Shaar BA, Almamlouk R, Riaz M, et al. Prevalence of post-acute COVID-19 syndrome symptoms at different follow-up periods: a systematic review and meta-analysis. Clin Microbiol Infect. 2022;28(5):657-66. https://doi.org/10.1016/j.cmi.2022.01.014
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