Palabras clave
Dabetes Mellitus
Cancer
sarcomas
fibrosarcomas
Cancer
sarcomas
fibrosarcomas
Cómo citar
Cortázar, J., Gaitán Yanguas, M., & Sánchez Medina, M. (2018). Algunos Aspectos de la Coexistencia de Diabetes Mellitus y Cáncer. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, -4(2), 201–209. https://doi.org/10.53853/encr.-4.2.290
Resumen
Fragmento
En la coexistencia de Diabetes Mellitus y Cáncer se halla considerable número de puntos de interés, en todos los niveles, desde el molecular y el mitocondrial hasta el psicosocial.
Por ejemplo, está aún por determinar si un tipo dado de sarcomas —probablemente los más pertinentes los fibrosarcomas—, son capaces de producir substancias similares a la insulina en cuanto a efectos sobre glucosa-glicógeno-glucosa se refiere; o si simplemente producen sub-unidades de aminoácidos peptídicamente unidos, las cuales tendrían el carácter de Precursoras de moléculas mayores con acción similar a la insulina; o si podrían almacenar o retener insulina de proveniencia pancreática, unida o no a proteínas del plasma, para luego liberarla en grandes cantidades.
Citas
1. DOEGE, K.: "Fibro-sarcoma of mediastimun". Ann. Surg. 92:955, 1930.
2. STECKL, H. P. G.: "Postmortem hepatic glycogenolysis in hyperinsulinism and glycogen disease". J. Clin. Invest. 18:723, 1939.
3. ARKLESS, H. A.: «“Coincidence of rabdomyofibroma of diaphragm, idiopathic hypoglicemia and retroperitoneal sarcoma”. Med. Bull. Vet. Adm. 19:225, 1942.
4. HINES, R. E.: «“Hypoglicemia apparenthly due to retroperitoneal sarcoma”. Med. Bull. Vet. Adm. 20:102, 1943.
5. ROSENFELD. D. E.: “Peritoneal pseudomyxoma: report of four unusual cases". Arch. Path. 48:255, 1949.
6. SKIILLERN, P. G. Jr; MCCORMACK, L. J.; HEWLETT, J. S. and CRILE, G. Jr. "Hyperinsulinism due to islet-cell tumor simulating sarcoma: report of 2 cases of large tumors composed of round and spindle cells associated with hypoglycemia". Diabetes 3:133, 1954.
7. HOLTEN, C.; “Hypoglycemia inducing-tumor resembling spindle-cell sarcoma". Acta Med. Scandinav. 157:97, 1957.
8. SCHOLTZ, D. A.; WOOLNER, L. B. and PRIESTLY, J. T.: “Spontaneous hypoglycemia associated with fibrogenic tumor: repor of two cases". Ann. Int.
Med. 46:796, 1957.
9. AUGUST, J. T. and HIATT, H. H.: “Severe hypoglycemia secondary to a non pancreatic fibrosarcoma with insulin activity". New Eng. J. Med. 258: 17, 1958.
10. ANDREEW, D.; GARANOW, I. and KRESTINOW, G.: "Hypoglycemia in intrathoracic fibroma”. Endokrinologie 38:167, 1959.
11. BOSS, H. H.; "Spontane hypoglykamie als Folge eines nicht-insulinproduzierenden. Tumors der Nebennieren región”. Schweisz. Ztschr. f. allg. Path. 22:232, 1959.
12. ROSSMAN, E. M.: "Mediatinal neurofibrosarcoma causing hypoglycemia”. Arch. Int. Med. 104: 640, 1959.
13. GOLD, G. L. and SCHNIDER, B. I.: "Some unusual syndromes associated with neoplastic disease". Ann. Int. Med. 51:890, 1959.
14. SELLMAN, J. C.; PERKOFF, G. T.; NULL, KIMMEL J. R. and TYLER, F. H.: Hypoglycemia associated with massive intra-abdominal mesothelial-cell sarcoma". New Eng. J. Med. 260: 847, 1959.
15. MILLER, D. R.; BOLNGER, R. E.; JANIGAN. D.; CROCKETT, J. E. and FREIPEN, S. R.: "Hypoglycemia due to nonpancreatic mesodermal tumors: report of two cases". Ann. Surg. 150:684, 1959.
16. KLEIN, H. and KLEIN, S. P.: "Spontaneous hypoglycemia associated with massive hepatoma: review of current concepts an report of case", A. M. A. Arch. int. Med. 103:273, 1959.
17. VOLK B:W.: "Spontaneous hypoglycemia with abdominal spindle-cell sarcoma" Geriatrics 15:473, 1960.
18. PEDERSEN, J.; LUNG, F. and RONGSTED, J.: "Hypoglycemia in presence of massive fibrosarcoma (mesenchymoma)”. Acta endocrinol. 34:148, 1960.
19. BOUSVAROS, G. A.: “Hypoglycemia in metastatic fibrosarcoma of liver” Brit. Med. J. 1:836, 1960
20. DUNCAN, C. G. and SCHLESS, G. L.: "Massive retroperitoneal fibrosarcoma, spontaneous hypoglycemia and generalized splachnomegaly: repor of case". Metabolism 10:200, 1961.
21. SCHONFELD, A.; BABBOTT, D. and GUNDERSEN, K.: "Hypoglycemia and polycythemia associated with primary hepatoma". New Eng. J. Med. 265: 231, 22. HAYES D.M.; SPURR, C. L.; FELTS, J. H. and MILLER, E. C. Jr: "Von Recklinghausen's disease with massive intra-abdominal tumor and spontaneous Hypoglicemia; metabolic studies before and after perfusion of abdominal cavity with nitrogen mustard". Metab. Clin. & Exper. 10:183, 1961.
23. LOWBEER, L.: "Hypoglycemia-producing extrapancreatic neoplasms: review Am. J. Clin. Path. 35: 233, 1961.
24. WHINTNEY, J. E. and HELLER, B. I.: "Increase insulin-like activity of serum in patient with spontaneous hypoglycemia associated with retroperitoneal fibrosarcoma”. Am. J. Med. 30: 633, 1961.
25. WHITNEY, J. E. and MASSEY, C. G.: "Apparent insulin activity in a fibrosarcoma associated with spontaneous hypoglycemia”. J. Clin Endocrinol
tab. 21: 541, 1961.
26. OLEESKY, S.; BAILEY, I.; SAMOLS, E. and BILKUS, D.: “Fibrosarcoma with hypoglycemia and high serum-insulin level". Lancet 2: 378, 1962.
27. TRANQUADA, R. E.; BENDER, A. B. and BIEGELMAN, P. M.: "Hypoglicemia associated with carcinoma of the cecum and syndrome of testicular
feminization". New Eng. J. Med. 266: 1302, 1962.
28. FILED, J. B.; KEEN, H.; JOHNSON, P. and HERRING, B.: “Insulin-like activity of nonpanchreatic tumors associated with hypoglycemia”. J. Clin.
docrinol. & Metab. 23: 1229, 1963
29. HEISKALA, H. and GYLLING, M.: "Hypoglycemia associated with sarcoma" Ann. Med. Int. Fenniae 52: 147, 1963.
30. BOSHELL, R. R.: KIRSCHENFELD, J. J. and SOTERES, P. S.: "Extrapancreatic insulin-secreting tumor". New Eng. J. Med. 270: 338, 1964.
31. LOUTFI, A. H.; MEHREZ, I.; SHADBENDER, S. and ABDINE, F. H.: “Hypoglycemia with Wilm's tumor". Arch. Dis. Childhood 39: 194, 1964.
32. VALLENCE-OWEN, J. and HURLOCK, B.: “Estimation of plasma-insulin by rat diaphragm method". Lancet 1: 68, 1954.
33. MARTIN, D. B., RENOLD, A. E. and DAGENAIS, Y. M.; "An assay for insulin-like activity using rat adipose tissue". Lancet 2: 76, 1958.
34. YALOW, R. S. and BERSON, S. A.: “Immunoassay of endogenous plasma insulin in man”. J. Clin. Invest. 39: 1157, 1960.
35. RENOLD, A. E.; MARTIN, D. R.; DAGENAIS, Y. M.; STEINKE, J.; NICKERSON, R. J. and SHEPS, M. C.: "Measurement of small quantities of insulin-like activity using rat adipose tissue. I. A, proposed procedure" J. Clin. Investi 39: 1487, 1960.
36. ARQUILLA, E. R.; RODARI, T. i CROSIGNANI, P. G.: "Determinazione inmunológica dell' insulina plasmática. Aspetti metodologici". Arch. Sci. Me
100: 471, 1960.
37. ANTONIADES, H. N.; BEIGELMAN,, P. M.; TRANQUADA, R. B. and GUNDERSEN, K.: "Studies on state of insulin in blood: "free" insulin and insulin complexes in human sera and their in vitro biological properties". Endocrinology 69: 46, 1961. 38. BEIGELMAN, P.M.: "Human serun insulin-like activity as determined by adipose tissue bio-assay method". Diabetes 10: 130, 1961
39. ANTONIADES, H. and GUNDERSEN, K.: “Studies on the state of in insulin in blood: materials and methods for the stimation of "free" and "bound
insulin-like activity in serum. Endocrinology 70: 95, 1962.
40. SALANS, L. and REAVEN, G.: "Plasma insulin-like activity (ILA) in Diabetes mellitus". Clin. Res. Proc. 12: 280, 1964.
41. SAMOLS, E. and BILKUS, D. A.: “A comparison of insulin immunoassays proc. Soc. Exp. Biol. 115: 79, 1964.
42. POWER, L.; REYES-LEAL, B. and CONN, J. W.: "Serum insulin-like activity in genetic and experimental diabetes mellitus". Metabolism 13: 1297, 1964.
43. UNGER, R. H.; LOCHNER, J. and EISENTRAUT, A. M.: "Indentification of two hormones in a bronchogenic metastasis". Clin. Res. Proc. 12: 288, 1965.
44. PRUITT. K. M.; BOSHELL, B. R. and KRESBERG, R. A.: "Insulin like activity. What is it?". Clin. Res. Proc. 13: 73, 1965.
45. ANTONIADES, H.: "Bound' insulin and tissue resistance to insulin": Lancet 2: 159, 1965.
46. WARBURG, O.: “The metabolism of tumors". Contable Ed., London, 1930.
47. LE PAGE G.A.; "Phosphorylated intermediates in tumor glycolysis. Analysis of tumors". Cancec. Res. 8: 193, 1948.
48. OLSON, R. E.: "Symposium: intermediary carbohydrate metabolism in tumor tissue: oxidation of C-14-labeled carbohydrate intermediates in tumor and normal tissue". Cancec. Res. 11: 571, 1951.
49. SCHUURMANS, R.: "Glucoce metabolism by malignant tumors". Geneesk. Gids. 39: 34, 1961
50. ROSENFELD, D. E.: Op. Cit. 5.
51. SILVIS R. S. and SIMON, D. S.: "Marked hypoglycemia associated with non-pancreatic tumors". New Eng. J. Med. 254: 14, 1956.
_______________________________________________
19-A DEROT, M.; GOURY -LAFONT, M.; RATHERY, M. et ROUDIER, R.; "2 cases of malignant tumors of the liver revealed by clinical manifestations of hypoglycemia". Bull. Soc. Med. Hop. París, 76: 364 1960.
19-B MEYER-HOFMANN, G.; SCHWARZKOPF, H. und HARTMAN, H.; “Spontaneous hypoglycemia with extrapancreatic tumors". Deutsch. Med. Wschr. 85: 2106, 1960.
25-A SACHSSE, B.; “Endogenous hypoglycemia as a result of extrapancreatic tumors". Med. Klin. 56: 714, 1961.
25-B FAST. B. B.: “Hypoglycemia associated with massive intra-abdominal mesenchymal tumor". Winnipeg Clin. Quart. 15: 104, 1962.
27-B LEGER, L.; SORS, C.; DUBOST, C.; MAGDELAINE M.; LEJEUNE, J. ROSEAU, E. et LEMAIGRE, G.; “The hypoglycemias of extrapancreatic mesenchymal tumors". Presse. Med. 71: 219, 1963.
2. STECKL, H. P. G.: "Postmortem hepatic glycogenolysis in hyperinsulinism and glycogen disease". J. Clin. Invest. 18:723, 1939.
3. ARKLESS, H. A.: «“Coincidence of rabdomyofibroma of diaphragm, idiopathic hypoglicemia and retroperitoneal sarcoma”. Med. Bull. Vet. Adm. 19:225, 1942.
4. HINES, R. E.: «“Hypoglicemia apparenthly due to retroperitoneal sarcoma”. Med. Bull. Vet. Adm. 20:102, 1943.
5. ROSENFELD. D. E.: “Peritoneal pseudomyxoma: report of four unusual cases". Arch. Path. 48:255, 1949.
6. SKIILLERN, P. G. Jr; MCCORMACK, L. J.; HEWLETT, J. S. and CRILE, G. Jr. "Hyperinsulinism due to islet-cell tumor simulating sarcoma: report of 2 cases of large tumors composed of round and spindle cells associated with hypoglycemia". Diabetes 3:133, 1954.
7. HOLTEN, C.; “Hypoglycemia inducing-tumor resembling spindle-cell sarcoma". Acta Med. Scandinav. 157:97, 1957.
8. SCHOLTZ, D. A.; WOOLNER, L. B. and PRIESTLY, J. T.: “Spontaneous hypoglycemia associated with fibrogenic tumor: repor of two cases". Ann. Int.
Med. 46:796, 1957.
9. AUGUST, J. T. and HIATT, H. H.: “Severe hypoglycemia secondary to a non pancreatic fibrosarcoma with insulin activity". New Eng. J. Med. 258: 17, 1958.
10. ANDREEW, D.; GARANOW, I. and KRESTINOW, G.: "Hypoglycemia in intrathoracic fibroma”. Endokrinologie 38:167, 1959.
11. BOSS, H. H.; "Spontane hypoglykamie als Folge eines nicht-insulinproduzierenden. Tumors der Nebennieren región”. Schweisz. Ztschr. f. allg. Path. 22:232, 1959.
12. ROSSMAN, E. M.: "Mediatinal neurofibrosarcoma causing hypoglycemia”. Arch. Int. Med. 104: 640, 1959.
13. GOLD, G. L. and SCHNIDER, B. I.: "Some unusual syndromes associated with neoplastic disease". Ann. Int. Med. 51:890, 1959.
14. SELLMAN, J. C.; PERKOFF, G. T.; NULL, KIMMEL J. R. and TYLER, F. H.: Hypoglycemia associated with massive intra-abdominal mesothelial-cell sarcoma". New Eng. J. Med. 260: 847, 1959.
15. MILLER, D. R.; BOLNGER, R. E.; JANIGAN. D.; CROCKETT, J. E. and FREIPEN, S. R.: "Hypoglycemia due to nonpancreatic mesodermal tumors: report of two cases". Ann. Surg. 150:684, 1959.
16. KLEIN, H. and KLEIN, S. P.: "Spontaneous hypoglycemia associated with massive hepatoma: review of current concepts an report of case", A. M. A. Arch. int. Med. 103:273, 1959.
17. VOLK B:W.: "Spontaneous hypoglycemia with abdominal spindle-cell sarcoma" Geriatrics 15:473, 1960.
18. PEDERSEN, J.; LUNG, F. and RONGSTED, J.: "Hypoglycemia in presence of massive fibrosarcoma (mesenchymoma)”. Acta endocrinol. 34:148, 1960.
19. BOUSVAROS, G. A.: “Hypoglycemia in metastatic fibrosarcoma of liver” Brit. Med. J. 1:836, 1960
20. DUNCAN, C. G. and SCHLESS, G. L.: "Massive retroperitoneal fibrosarcoma, spontaneous hypoglycemia and generalized splachnomegaly: repor of case". Metabolism 10:200, 1961.
21. SCHONFELD, A.; BABBOTT, D. and GUNDERSEN, K.: "Hypoglycemia and polycythemia associated with primary hepatoma". New Eng. J. Med. 265: 231, 22. HAYES D.M.; SPURR, C. L.; FELTS, J. H. and MILLER, E. C. Jr: "Von Recklinghausen's disease with massive intra-abdominal tumor and spontaneous Hypoglicemia; metabolic studies before and after perfusion of abdominal cavity with nitrogen mustard". Metab. Clin. & Exper. 10:183, 1961.
23. LOWBEER, L.: "Hypoglycemia-producing extrapancreatic neoplasms: review Am. J. Clin. Path. 35: 233, 1961.
24. WHINTNEY, J. E. and HELLER, B. I.: "Increase insulin-like activity of serum in patient with spontaneous hypoglycemia associated with retroperitoneal fibrosarcoma”. Am. J. Med. 30: 633, 1961.
25. WHITNEY, J. E. and MASSEY, C. G.: "Apparent insulin activity in a fibrosarcoma associated with spontaneous hypoglycemia”. J. Clin Endocrinol
tab. 21: 541, 1961.
26. OLEESKY, S.; BAILEY, I.; SAMOLS, E. and BILKUS, D.: “Fibrosarcoma with hypoglycemia and high serum-insulin level". Lancet 2: 378, 1962.
27. TRANQUADA, R. E.; BENDER, A. B. and BIEGELMAN, P. M.: "Hypoglicemia associated with carcinoma of the cecum and syndrome of testicular
feminization". New Eng. J. Med. 266: 1302, 1962.
28. FILED, J. B.; KEEN, H.; JOHNSON, P. and HERRING, B.: “Insulin-like activity of nonpanchreatic tumors associated with hypoglycemia”. J. Clin.
docrinol. & Metab. 23: 1229, 1963
29. HEISKALA, H. and GYLLING, M.: "Hypoglycemia associated with sarcoma" Ann. Med. Int. Fenniae 52: 147, 1963.
30. BOSHELL, R. R.: KIRSCHENFELD, J. J. and SOTERES, P. S.: "Extrapancreatic insulin-secreting tumor". New Eng. J. Med. 270: 338, 1964.
31. LOUTFI, A. H.; MEHREZ, I.; SHADBENDER, S. and ABDINE, F. H.: “Hypoglycemia with Wilm's tumor". Arch. Dis. Childhood 39: 194, 1964.
32. VALLENCE-OWEN, J. and HURLOCK, B.: “Estimation of plasma-insulin by rat diaphragm method". Lancet 1: 68, 1954.
33. MARTIN, D. B., RENOLD, A. E. and DAGENAIS, Y. M.; "An assay for insulin-like activity using rat adipose tissue". Lancet 2: 76, 1958.
34. YALOW, R. S. and BERSON, S. A.: “Immunoassay of endogenous plasma insulin in man”. J. Clin. Invest. 39: 1157, 1960.
35. RENOLD, A. E.; MARTIN, D. R.; DAGENAIS, Y. M.; STEINKE, J.; NICKERSON, R. J. and SHEPS, M. C.: "Measurement of small quantities of insulin-like activity using rat adipose tissue. I. A, proposed procedure" J. Clin. Investi 39: 1487, 1960.
36. ARQUILLA, E. R.; RODARI, T. i CROSIGNANI, P. G.: "Determinazione inmunológica dell' insulina plasmática. Aspetti metodologici". Arch. Sci. Me
100: 471, 1960.
37. ANTONIADES, H. N.; BEIGELMAN,, P. M.; TRANQUADA, R. B. and GUNDERSEN, K.: "Studies on state of insulin in blood: "free" insulin and insulin complexes in human sera and their in vitro biological properties". Endocrinology 69: 46, 1961. 38. BEIGELMAN, P.M.: "Human serun insulin-like activity as determined by adipose tissue bio-assay method". Diabetes 10: 130, 1961
39. ANTONIADES, H. and GUNDERSEN, K.: “Studies on the state of in insulin in blood: materials and methods for the stimation of "free" and "bound
insulin-like activity in serum. Endocrinology 70: 95, 1962.
40. SALANS, L. and REAVEN, G.: "Plasma insulin-like activity (ILA) in Diabetes mellitus". Clin. Res. Proc. 12: 280, 1964.
41. SAMOLS, E. and BILKUS, D. A.: “A comparison of insulin immunoassays proc. Soc. Exp. Biol. 115: 79, 1964.
42. POWER, L.; REYES-LEAL, B. and CONN, J. W.: "Serum insulin-like activity in genetic and experimental diabetes mellitus". Metabolism 13: 1297, 1964.
43. UNGER, R. H.; LOCHNER, J. and EISENTRAUT, A. M.: "Indentification of two hormones in a bronchogenic metastasis". Clin. Res. Proc. 12: 288, 1965.
44. PRUITT. K. M.; BOSHELL, B. R. and KRESBERG, R. A.: "Insulin like activity. What is it?". Clin. Res. Proc. 13: 73, 1965.
45. ANTONIADES, H.: "Bound' insulin and tissue resistance to insulin": Lancet 2: 159, 1965.
46. WARBURG, O.: “The metabolism of tumors". Contable Ed., London, 1930.
47. LE PAGE G.A.; "Phosphorylated intermediates in tumor glycolysis. Analysis of tumors". Cancec. Res. 8: 193, 1948.
48. OLSON, R. E.: "Symposium: intermediary carbohydrate metabolism in tumor tissue: oxidation of C-14-labeled carbohydrate intermediates in tumor and normal tissue". Cancec. Res. 11: 571, 1951.
49. SCHUURMANS, R.: "Glucoce metabolism by malignant tumors". Geneesk. Gids. 39: 34, 1961
50. ROSENFELD, D. E.: Op. Cit. 5.
51. SILVIS R. S. and SIMON, D. S.: "Marked hypoglycemia associated with non-pancreatic tumors". New Eng. J. Med. 254: 14, 1956.
_______________________________________________
19-A DEROT, M.; GOURY -LAFONT, M.; RATHERY, M. et ROUDIER, R.; "2 cases of malignant tumors of the liver revealed by clinical manifestations of hypoglycemia". Bull. Soc. Med. Hop. París, 76: 364 1960.
19-B MEYER-HOFMANN, G.; SCHWARZKOPF, H. und HARTMAN, H.; “Spontaneous hypoglycemia with extrapancreatic tumors". Deutsch. Med. Wschr. 85: 2106, 1960.
25-A SACHSSE, B.; “Endogenous hypoglycemia as a result of extrapancreatic tumors". Med. Klin. 56: 714, 1961.
25-B FAST. B. B.: “Hypoglycemia associated with massive intra-abdominal mesenchymal tumor". Winnipeg Clin. Quart. 15: 104, 1962.
27-B LEGER, L.; SORS, C.; DUBOST, C.; MAGDELAINE M.; LEJEUNE, J. ROSEAU, E. et LEMAIGRE, G.; “The hypoglycemias of extrapancreatic mesenchymal tumors". Presse. Med. 71: 219, 1963.
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