New therapies for medullary thyroid carcinoma
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medullary thyroid carcinoma
c-ret proto-oncogene proteins

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Román-González, A., Mejía, S., & Zapata, M. (2019). New therapies for medullary thyroid carcinoma. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 6(4), 306–310.


Patients with advanced medullar thyroid carcinoma have limited options. Current approved therapies for this cancer are vandetanib and cabozantinib. However, the non-specific inhibition produces side effects limiting its use in clinical practice. For example, vandetanib may prolongate QT and in rare cases trigger ventricular arrhythmias. Cabozantinib may be associated with hypertension, hand-and-foot syndrome, fistula and gastrointestinal perforation with bleeding.
RET alterations are associated with medullary thyroid carcinoma as well as other types of cancer such as lung cancer. Specific inhibition of this tyrosine kinase by LOXO-292 y BLU-677 is safe and limited only to RET, without inhibition of other tyrosine kinases. Therefore, its clinical use is promising given its excellent clinical responses and infrequent side effects compared to available tyrosine kinase inhibitors.
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