Revista Colombiana de Endocrinología, Diabetes y Metabolismo
Recommendations of the expert panel on the pathophysiology, diagnosis and treatment of dyslipidemias in the adult population. Colombian Association of Endocrinology, Diabetes and Metabolism and Colombian Society of Cardiology and Cardiovascular Surgery
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Vargas-Uricoechea, H., Ruiz, A. J., Gómez, E. A., Román-González, A., Castillo, J., Merchán, A., & Toro, J. M. (2020). Recommendations of the expert panel on the pathophysiology, diagnosis and treatment of dyslipidemias in the adult population. Colombian Association of Endocrinology, Diabetes and Metabolism and Colombian Society of Cardiology and Cardiovascular Surgery. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 7(1S), 4–36.


Cardiovascular diseases are the leading cause of morbidity and mortality in the world, both in developed and developing countries. Dyslipidemia –associated with endothelial dysfunction- and vascular inflammatory phenomena are the initial processes in the pathogenesis of arteriosclerotic arterial disease. The direct and linear association between LDLc levels and the risk of arteriosclerotic arterial disease is evident, as is the beneficial effect of the intervention with drugs that act at different levels (statins, ezetimibe, fibrates, iPCSK9, etc.). Moreover, hypertriglyceridemia, and low levels of HDL-C, as well as other parameters such as non-HDLc and other lipoproteins, also play an important role in the etiopathogenesis of arteriosclerotic disease, and there is evidence in favor of the modification of said parameters. The new drugs have substantially modified the cardiovascular results in individuals with high cardiovascular risk, and in individuals with intolerance to statins. The different international guidelines for the management of dyslipidemia share many aspects regarding pharmacological and non-pharmacological management, however, there are some important differences between them; even in the way of dealing with individuals with special dyslipidemia situations (pregnancy, chronic kidney disease, inter alia).
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