Tyrosine-kinase inhibitors for thyroid carcinoma
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proto-oncogene proteins B-raf
thyroid neoplasms
protein kinase inhibitors

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Román-González, A., Zapata, M. L., & Mejia, S. (2021). Tyrosine-kinase inhibitors for thyroid carcinoma. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 7(3), 170–176. https://doi.org/10.53853/encr.7.3.629


ntroduction: Thyroid carcinoma is the most common endocrine neoplasia. An increase in the prevalence of this disease has been found and maybe related to over-diagnosis. However, an increase in larger tumor, aggressive variants and mortality has also been found. The cause of this change if currently unknown. Most patients with thyroid cancer have localized, low-risk disease. Between 1 to 5 % of thyroid carcinoma have metastasis. Half of them may have radioactive resistant tumor. Therapeutical options in these patients has been limited.
Methods: A literature review of randomized clinical trials versus placebo evaluating tyrosine-kinase inhibitors in thyroid carcinoma was performed. A synthesis of the results is presents was well as general indications for metastatic disease management.
Results: To the date of publication of this article, the only approved drug in Colombia to treat advanced thyroid carcinoma is sorafenib. In other countries, Lenvatinib has been approved. The combination of dabrafenib plus trametinib was recently approved by the FDA to be used in patients with BRAF mutations. An active management of side effects is required for a successful and safe treatment.
Conclusions: Radioactive resistant thyroid carcinoma is a clinical challenge. Tyrosine-kinase inhibitors are an option for these patients. Side effects management is essential for an appropriate and successful use.

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