Management of hyperglycemia associated with pasireotide in patients with Cushing’s disease or acromegaly. Recommendations from a panel of experts
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Pituitary ACTH Hypersecretion

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Pinzón-Tovar, A. ., Abreu Lomba, A. ., Arenas, H. M., Gomez Giraldo, C. M. ., Pantoja Guerrero, D. ., Valenzuela, A. ., García, A. F. ., & Buitrago Gómez, N. (2022). Management of hyperglycemia associated with pasireotide in patients with Cushing’s disease or acromegaly. Recommendations from a panel of experts. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 9(3).


Context: Pasireotide has demonstrated efficacy in the treatment of cushings disease and acromegaly; however, it is common for patients treated with pasireotide to have hyperglycaemia.

Objective: To provide for Colombia a management guide for hyperglycemia secondary to pasireotide administration in patients with acromegaly or Cushing's disease.

Methods: The Experts panel performed a thorough review of the available evidence to answer clinical questions made by experienced endocrinologists around the country. During the panel, the experts used the updated evidence to formulate recommendations.

Results: The panel made sixteen recommendations for treating hyperglycemia in patients with Cushing's disease and seven for acromegaly receiving pasireotide. Guidance is both evidence and experience-based.

Conclusions: Although pasireotide is an effective therapy for inoperable pituitary tumors, its secondary hyperglycemia and diabetes are complications to be considered. There is little evidence to support specific recommendations to treat primary or secondary hyperglycemia in these patients, here the recommendations were based on expert opinion and are the first published for Colombia.
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