Keywords
bariatric surgery
GLP-1 analogs
liraglutide
gastric sleeve
ketogenic diet
How to Cite
Abstract
Purpose: To evaluate the effectiveness of Liraglutide for management of patients with inadequate weight loss (<20% of body weight) after gastric sleeve.
Methodology: Data was collected from 18 patients who underwent gastric sleeve at the Centro Medico Imbanaco, who 2 years after the surgical procedure presented an inadequate weight loss, defined as a loss of less than 20% respect to initial weight. 55.6% were men, 44.4% were women, 22.2% had a history of diabetes and 55.6% of arterial hypertension. The weight of the patients was monitored at weeks 0, 12 and 24 of treatment. The data were analyzed with the Friedman method for dependent variables.
Results: Weight reduction was found at the end of liraglutide management, the mean weight loss was 22.22% (21.27 kg) with respect to the pre-surgical weight and it was statistically significant (P <0.005).
Conclusions: Management with liraglutide is an effective option in patients with inadequate weight loss after gastric sleeve surgery.
References
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 105: Bariatric Surgery and Pregnancy. Obstet Gynecol. 2009;113(6):1405-13. https://doi.org/10.1097/AOG.0b013e3181ac0544
Organización Mundial de la Salud [sitio virtual]. Obesidad y sobrepeso; 2019 [citado 2019 jul. 21]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/obesity-and-overweight
Busetto L, Dicker D, Azran C, Batterham RL, Farpour-Lambert N, Fried M, et al. Obesity Management Task Force of the European Association for the Study of Obesity Released “Practical Recommendations for the Post-Bariatric Surgery Medical Management”. Obes Surg. 2018 jul. 1;28(7):2117-21. https://doi.org/10.1007/s11695-018-3283-z
Minsalud [sitio virtual]. Encuesta Nacional de Situación Nutricional (ENSIN). Minsalud; 2019 [citado 2019, jul. 21]. Disponible en: https://www.minsalud.gov.co/salud/publica/epidemiologia/Paginas/encuesta-nacional-de-situacion-nutricional-ensin.aspx
Dagan SS, Goldenshluger A, Globus I, Schweiger C, Kessler Y, Sandbank GK, et al. Nutritional recommendations for adult bariatric surgery patients: Clinical practice. Adv Nutr. 2017;8:382-94. https://doi.org/10.3945/an.116.014258
Di Cesare M, Bentham J, Stevens GA, Zhou B, Danaei G, Lu Y, et al. Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 2016 abr. 2;387(10026):1377-96. https://doi.org/10.1016/S0140-6736(16)30054-X
Farha J, McGowan C, Hedjoudje A, Itani MI, Abbarh S, Simsek C, et al. Endoscopic sleeve gastroplasty: Suturing the gastric fundus does not confer benefit. Endoscopy. 2021 jul. 1;53(7):727-31. https://doi.org/10.1055/a-1236-9347
Gagnon C, Schafer AL. Bone Health After Bariatric Surgery. JBMR Plus. 2018;2(3):121-33. https://doi.org/10.1002/jbm4.10048
Halawi H, Khemani D, Eckert D, O’Neill J, Kadouh H, Grothe K, et al. Effects of liraglutide on weight, satiation, and gastric functions in obesity: a randomised, placebo-controlled pilot trial. Lancet Gastroenterol Hepatol. 2017 dic. 1;2(12):890-9. https://doi.org/10.1016/S2468-1253(17)30285-6
Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: A report of the American College of cardiology/American Heart Association task force on practice guidelines and the obesity society. Circulation. 2014; 129(25):S102-38. https://doi.org/10.1161/01.cir.0000437739.71477.ee
Kelly AS, Auerbach P, Barrientos-Pérez M, Gies I, Hale PM, Marcus C, et al. A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity. N Engl J Med. 2020 my. 28;382(22):2117-28. https://doi.org/10.1056/NEJMoa1916038
Ladenheim EE. Liraglutide and obesity: A review of the data so far. Drug Des Dev Ther. 2015;9:1867-75. https://doi.org/10.2147/DDDT.S58459
Pajecki D, Halpern A, Cercato C, Mancini M, Cleva RD, Santo MA. Short-term use of liraglutide in the management of patients with weight regain after bariatric surgery. Rev Col Bras Cir. 2013;40(3):191-5. https://doi.org/10.1590/S0100-69912013000300005
Thakur U, Bhansali A, Gupta R, Rastogi A. Liraglutide Augments Weight Loss After Laparoscopic Sleeve Gastrectomy: a Randomised, Double-Blind, Placebo-Control Study. Obes Surg. 2021 en. 1;31(1):84-92. https://doi.org/10.1007/s11695-020-04850-4
Webb DL, Abrahamsson N, Sundbom M, Hellström PM. Bariatric surgery-time to replace with GLP-1? Scand J Gastroenterol. 2017;52:635-40. https://doi.org/10.1080/00365521.2017.1293154
Wharton S, Kuk JL, Luszczynski M, Kamran E, Christensen RA. Liraglutide 3.0 mg for the management of insufficient weight loss or excessive weight regain post?bariatric surgery. Clin Obes. 2019 ag.;9(4). https://doi.org/10.1111/cob.12323
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2022 Revista Colombiana de Endocrinología, Diabetes & Metabolismo