Keywords
Diabetes Insípida Nefrogénica
demetil - clor- tetraciclina
demetil - clor- tetraciclina
How to Cite
Hayek Díaz, A., Ramírez Perdomo, J., & Jácome Roca, A. (2018). Diabetes insípida nefrogénica. UNA COMPLICACIÓN DE LA DEMETIL-CLOR-TETRACICLINA. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, -10(1), 34–36. https://doi.org/10.53853/encr.-10.1.203
Abstract
Se presentan 2 casos de Diabetes Insípida Nefrogénica secundaria a la ingestión de demetil - clor- tetraciclina. El mecanismo de acción de este tipo de Diabetes Insípida parece ser un bloqueo parcial de la acción de la hormona antidiurética endógena en el túbulo renal, posiblemente causado por un impedimento en la producción y acción del AMP-cíclico. Este defecto nefronégico depende de la dosis usada y es reversible.
References
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2) Dousa TP, Wilson DM: Tetracyclines: interference with ADH, responsive cyclic AMP system in human renal medulla, Clin Res 21: 75, 1973.
3) Castell, D.O., Sparks, H.A.: Nephrogenic diabetes insipidus due to demethylchlortetracycline hydrochloride, J.A.M.A. 193: 137-139, 1965.
4) Roth, H., Becker, K.L., Shalhoub, R.S. et al.: Nephrotoxicity of demethylchlortetracycline hydrochloride, Arch Int Med 120: 433-435, 1967.
5) Rotenberg, D., Singer, I.: Demeclocycline (DMC)-Induced diabetes insipidus, (abs tract), Clin Res 20: 894, 1972.
6) Singer, I., Rotemberg, D.: Demeclocycline-induced nephrogenic diabetes insipidus, in-vivo and in-vitro studies, Ann Intern Med 79: 679-683, 1973.
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