Importancia de la Medición de Triiodotironina en Suero como Prueba de Evaluación Tiroidea
PDF (Español (España))

Keywords

Triiodotironina
evaluación tiroidea
enfermedad de Graves

How to Cite

Gaitán, J. E., Wahner, H. W., & Gaitán, E. (2018). Importancia de la Medición de Triiodotironina en Suero como Prueba de Evaluación Tiroidea. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, -9(1), 29–41. https://doi.org/10.53853/encr.-9.1.210

Abstract

Fragmento

En el control y seguimiento de pacientes tratados con yodo radioactivo (131I) por enfermedad de Graves y bocio modular tóxico, la evaluación del estado funcional de la glándula tiroides es importante porque hay una alta incidencia de hipotiroidismo, y en algunos una recurrencia del hipertiroidismo. La mayor incidencia de hipotiroidismo se presenta en los primeros años después del tratamiento. sin embargo la posibilidad de desarrollar hipotiroidismo puede presentarse con el transcurso de los años.

ABSTRACT:

68 patients treated with 131I-iodide for Grave's and Plummer's Disease in Cali, Colombia were studied. TT4. PBI, T3 uptake, TBG and TSH were used to define their thyroid state. Serum T3 measurements (Radio Immunoassay) were performed in all and the importance to define the thyroid state was studied.

A combination of TT4 and T3 uptake was helpful to classify the thyroid state in 81% of the patients. The remainder (19%) need additional tests (T3, TBG, TSH) for a correct classification. Two patients with clinical hyperthyroidism and normal serum TT4 had increased serum T3. The inappropriately normal TT4 value was not explained by deficiency of T4-binding globulin. One patient, clinically euthyroid, was maintained euthyroid by preferential secretion of T3 in the presence of low T4.

60% of the hypothyroid patients had serum T3 values in the normal range. These findings support the concept that TSH hypersecretion may result in T3 release despite diminished T4 secretions after radiation treatment. Measurements of serum T3 is useful in certain well-defined situations.

 

 

https://doi.org/10.53853/encr.-9.1.210
PDF (Español (España))

References

1. Beling, V., and Einhorn, J.: Incidence of hypothyroidism and recurrences following 131I treatment of hyperthyroidism. Acta Radiol., 56:275, 1961.
2. Nofal, M.M., Beierw-altes, W.H. and Patuo, M.E.: Treatment of hyperthyroidism with sodium iodide 131I. J.A.M.A., 197:605, 1966.
3. Arango, G., Mayberry, W. E., Hockert, T.J., et al.: Total and free human Serum thyroxine in normal and abnormal thyroid states. Mayo Clin. Proc. 43.
503-516, 1968.
4. Clark, F., and Horn, D.B.: Assessment of thyroid function by the combined use of the serum protein-bound iodine and resin uptake of 131I-triiodothy- ronine. J. Clin. Endocrinol. Metab. 25: 39-45, 1965,
5. Hollander, C.S.: On the nature of the circulating thyroid hormone: Clinical studies of triiodothyronine and thyroxine in serum using gas chromatographic methods. Trans. Assoc. Amer. Physicians, 81:76-91, 1968.
6. Sterling, K., Refetofff, S. and Selenkow, H.A.: T3 thyrotoxicosis. Thyrotoxicosis due to elevated serum triiodothyronine levels. J. Am. Med. Assoc., 213:
7. Wahner, H.W. and Gorman C. A.: Interpretation of serum triiodothyronine levels measured by the Sterling technic.N. Eng. J. Med., 284:225-230, 1971.
8. Sterling, K., Brenner. MA New man, E.S., Odell., W.D., Bellabarda, D. The significance of triiodothyronine (T3) in maintenance of enthyroid status after treatment of hyperthyroidism. J. Clin. Endocrino. Metab. 33:729
9. Wahner, H. W. Gaitan J.E. and Escalon, H.: El tratamiento del hipertiroidismo con bocio nodular y enfermedad de Graves yodo radioactivo. Revista de la Sociedad Colombiana de Endocrinología, 6 - 1:25, 30, Dic. 1968.
10. Clinical evaluation of a new method for the determination of thyroxine in serum. J. Clin. Endocrinol. Metab., 26:99, 1966.
11. Gimlet, T.M.D.: The use of Sephadex column chromatography in the assessment of thyroid status. J. Clin. Path., 20: 170 1967.
12. Roberts, R.C. and Nikolai, T. F.: Determination of thyroxinebinding globulin: A simplified procedure utilizing dextran-coated charcoal. Clin. Chem., 15:1132-1140, 1969.
13. Mayberry. W.E., Gharib, H., Bilstad, J.M., et al.: Radioimmunoassay for human thyrotropin: Clinical value in patients with normal and abnormal thyroid function. Ann. Intern. Med., 74: 471, 1971.
14. Gharib, H., Ryan, R.J. Mayberry. W. E. et al.: Radioimmunoassay for triodothyronine (T3). I. Affinity and specificity of the antibody for T3J. Clin, Endocrinol. Metab., 33:509-516, 1971.
15. Acland, J.D.: J. Clin. Path., 11:165, 1958.
16. Gharib, H... Wahner, H.W., Mc-Conahey, W.M.: Serum level of thyroid hormones in Hashimoto's Thyroiditis. Mayo Clin. Proc., 47:175-179, 1972.

Authors must state that they reviewed, validated and approved the manuscript's publication.  Moreover, they must sign a model release that should be sent.  A copy may be reviewed here

Dimensions


PlumX


Downloads

Download data is not yet available.