Introduction: The term Metabolically Healthy Obesity (ObMS) refers to a subgroup of obese patients who do not have metabolic syndrome and consequently seem to have fewer cardiovascular complications(1)
Objective: Describe the biochemical and anthropometric characteristics by body composition that differentiate the Obese Metabolically Healthy from the Obese Metabolically Sick.
Materials and methods: It is a cross-sectional study with obeses men aged between 18 and 30 years who were measured percentage of total fat, android and gynecoid by body composition, plasma levels of Total Cholesterol, HDL, LDL, VLDL, Triglycerides, Glycemia , PCR, insulin, leptin, adiponectin, galanin, total testosterone and estradiol in the fasted state and an oral glucose tolerance test (PTOG) was performed to measure blood sugar, insulin and Galanin, and the insulin-resistance index was determined. by HOMA IR.
Results: We found 16 patients with ObMS and 14 ObME patients. Basal hyperinsulinism and elevated HOMA IR were observed among subjects with ObMS, although to a lesser extent than in the ObME group (p0.009).
High levels of leptin, galanin and C-reactive protein were also found among the ObMS, comparable to those of the ObME and reduced levels of adiponectin, in the same magnitude between both groups of subjects
Conclusions: We found that basal insulin, HOMA-IR, leptin, galanin, PCR, adiponectin are altered among ObMS subjects, in the same magnitude as among ObMEs, suggesting that biochemical alterations are much earlier findings than changes in the clinical variables that define the metabolic syndrome.
Key Words: Obesity, Obese Metabolically Healthy, Obese Metabolically Sick, Metabolic Syndrome, Insulin-Resistance.
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