Role of selenium substitution in the treatment of hypothyroidism
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González Clavijo, A. M., Muñoz Loaiza, J. D., Marquez Fernandez, A. ., Chavez Rodríguez, L. M., Campos González, L. A., Alfonso Cedeño, D. F., & Rojas Serna, L. F. (2021). Role of selenium substitution in the treatment of hypothyroidism. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 8(2).


Introduction: Hypothyroidism is an endocrinopathy characterized by deficient action or production of thyroid hormones in the body. One of the less frequent etiologies is dysfunction of the deiodinase enzymes, which can be suspected when the thyroid profile shows elevated thyroid-stimulating hormone (TSH), high free thyroxine (T4) and low total or free triiodothyronine (T3).

Purpose: To discuss a case of hypothyroidism successfully treated with selenium and levothyroxine and to describe the role of selenium in thyroid disease.
Case presentation: 22-year-old man with abnormal thyroid profile characterized by elevated TSH, high free T4, and T3 in the lower limit, without finding of pituitary adenomas, mutations in the thyroid hormone receptor gene (THRB) or alterations in the Thyroxine-binding globulin, who was successfully treated with thyroid hormone and selenium supplementation.
Conclusion: when abnormal concentrations in TSH, T4 and T3 levels are not easily explained by other causes, disorders of the synthesis or function of deiodinases should be considered. Treatment with selenium and levothyroxine could help in the management of this pathology.
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