Keywords
Diabetes mellitus
dermatología
endocrinología
dermatología
endocrinología
How to Cite
Calderón, D. C., Rivera, A., & Medina, A. (2017). Diabetes mellitus y sus diferentes manifestaciones dermatológicas. Revisión de la literatura. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 4(3), 33–40. https://doi.org/10.53853/encr.4.3.134
Abstract
Extracto
Se presenta el caso de una paciente de 45 años de edad que consulta al servicio de dermatología por aparición de lesión en miembro inferior izquierdo de crecimiento progresivo, ocasionalmente dolorosa. Como antecedentes importantes presenta diabetes mellitus tipo 2 mal controlada, hipertensión arterial crónica, obesidad grado III e hipotiroidismo en suplencia. En manejo actual con metformina 2 veces día, insulina glargina 12 unidades día, losartán 50 mg día y levotiroxina 50 mcg al día.
Al examen físico se evidenciaba una placa de bordes bien definidos con centro atrófico de borde eritematoso con centro pálido mal definida con múltiples vasos en su superficie, que ocupaba el 70% de la región anterior del miembro inferior izquierdo.
References
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2. www.who.int/diabetes/global-report/es/.
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4. Shahzad M, Al Robaee A, Al Shobaili HA, Alzolibani AA, Al Marshood AA, Al Moteri B. Skin manifestations in diabetic patients attending a diabetic clinic in the Qassim region, Saudi Arabia. Medical principles and practice: international journal of the Kuwait University, Health Science Centre. 2011;20(2):137-41. Epub 2011/01/22.
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6. Reid SD, Ladizinski B, Lee K, Baibergenova A, Alavi A. Update on necrobiosis lipoidica: a review of etiology, diagnosis, and treatment options. Journal of the American Academy of Dermatology. 2013;69(5):783-91. Epub 2013/08/24.
7. Peyri J, Moreno A, Marcoval J. Necrobiosis lipoidica. Seminars in cutaneous medicine and surgery. 2007;26(2):87-9. Epub 2007/06/05.
8. Boateng B, Hiller D, Albrecht HP, Hornstein OP. [Cutaneous microcirculation in pretibial necrobiosis lipoidica. Comparative laser Doppler flowmetry and oxygen partial pressure determinations in patients and healthy probands]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. 1993;44(9):581-6. Epub 1993/09/01. Kutane Mikrozirkulation bei pratibialer Nekrobiosis lipoidica. Vergleichende Laser-Doppler-Fluxmetrie und Sauerstoffpartialdruckmessungen bei Patienten und Hautgesunden.
9. Ngo B, Wigington G, Hayes K, Huerter C, Hillman B, Adler M, et al. Skin blood flow in necrobiosis lipoidica diabeticorum. International journal of dermatology. 2008;47(4):354-8. Epub 2008/04/02.
10. Oikarinen A, Mortenhumer M, Kallioinen M, Savolainen ER. Necrobiosis lipoidica: ultrastructural and biochemical demonstration of a collagen de- fect. The Journal of investigative dermatology. 1987;88(2):227-32. Epub 1987/02/01.
11. Ullman S, Dahl MV. Necrobiosis lipoidica. An immunofluorescence study. Archives of dermatology. 1977;113(12):1671-3. Epub 1977/12/01.
12. Roche. E VJ, Velasco. M. Familial necrobiosis lipoidica not associated with diabetes. Dermatology Online Journal. 2007;3 (13):26
13. Sibbald. C RS, Alavi. F. Necrobiosis Lipoidica Dermatol Clin. 2015;33:343- 60.
14. Lynch JM, Barrett TL. Collagenolytic (necrobiotic) granulomas: part II-- the ‘red’ granulomas. Journal of cutaneous pathology. 2004;31(6):409-18. Epub 2004/06/10.
15. Thornsberry LA, English JC, 3rd. Etiology, diagnosis, and therapeutic management of granuloma annulare: an update. American journal of clinical dermatology. 2013;14(4):279-90. Epub 2013/05/23.
16. Piette EW, Rosenbach M. Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics. Journal of the American Academy of Dermatology. 2016;75(3):457-65. Epub 2016/08/21.
17. Dahl MV, Ullman S, Goltz RW. Vasculitis in granuloma annulare: histopathology and direct immunofluorescence. Archives of dermatology. 1977;113(4):463-7. Epub 1977/04/01.
18. Piette EW, Rosenbach M. Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. Journal of the American Academy of Dermatology. 2016;75(3):467-79. Epub 2016/08/21.
19. Chaitra V, Inchara YK, Rajalakshmi T, Antony M. Granuloma annulare - histology reconsidered. Indian journal of dermatology, venereology and leprology. 2010;76(5):568-9. Epub 2010/09/10.
20. Larsen K, Jensen T, Karlsmark T, Holstein PE. Incidence of bullosis diabeticorum--a controversial cause of chronic foot ulceration. International wound journal. 2008;5(4):591-6. Epub 2008/11/14.
21. Riad. H. AH, Mansour. K., Mannai. H., Sada. H., Shaikha. S. Dosari. S. Pruritic Vesicular Eruption on the Lower Legs in a Diabetic Female. Case Report. Case Reports in Dermatological Medicine. 2013;2013(641416):4.
22. Bolognia. L. JJL, Rapini. R. P. Other vesiculobullous diseases. Dermatology2008.
23. Lipsky BA, Baker PD, Ahroni JH. Diabetic bullae: 12 cases of a purportedly rare cutaneous disorder. International journal of dermatology. 2000;39(3):196-200. Epub 2000/04/12.
24. Jung SE, Kim YC. Scleredema of Buschke Following Streptococcal Infection. Annals of dermatology. 2015;27(4):478-80. Epub 2015/08/15.
25. Parmar RC, Bavdekar SB, Bansal S, Doraiswamy A, Khambadkone S. Scleredema adultorum. Journal of postgraduate medicine. 2000;46(2):91-3. Epub 2000/10/03.
26. All MCe. Scleredema diabeticorum in a patient with type 2 diabetes mel- litus. Case Rep Endocrinol. 2011;2011:560.
27. Pitarch. G. TA, Martínez-Aparicio. A., Vilata J., Fortea J. Escleredema de Buschke asociado a diabetes mellitus. Estudio de cuatro casos. Actas Der- mosifiliogr 2005;96(1):46-9.
28. Kovary PM, Vakilzadeh F, Macher E, Zaun H, Merk H, Goerz G. Monoclonal gammopathy in scleredema. Observations in three cases. Archives of dermatology. 1981;117(9):536-9. Epub 1981/09/01.
29. Besson C. A. KMC, Jacquet. P., Andrac, L., Sayag. J. Electron-beam therapy in scleredema adultorum with associated monoclonal hypergammaglobulinaemia. Br J Dermatol 1994;130(3):394–7.
30. Mattheou-Vakali G, Ioannides D, Thomas T, Lazaridou E, Tsogas P, Minas A. Cyclosporine in scleredema. Journal of the American Academy of Dermatology. 1996;35(6):990-1. Epub 1996/12/01.
31. Grundmann-Kollmann M, Ochsendorf F, Zollner TM, Spieth K, Kaufmann R, Podda M. Cream PUVA therapy for scleredema adultorum. Br J Dermatol. 2000;142(5):1058-9. Epub 2000/05/16.
32. Phiske MM. An approach to acanthosis nigricans. Indian dermatology online journal. 2014;5(3):239-49. Epub 2014/08/29.
33. James WD ED, Berger TG. Andrews Diseases of the Skin. Dermatology. C, editor2011. 494-5 p.
34. Judge MR MW, Munro CS. Disorders of keratinization. Burns T BS, Cox N, Griffiths C, editors, editor2010.
35. Hermanns-Le T, Scheen A, Pierard GE. Acanthosis nigricans associated with insulin resistance : pathophysiology and management. American journal of clinical dermatology. 2004;5(3):199-203. Epub 2004/06/10.
36. Tankova T, Koev D, Dakovska L, Kirilov G. Therapeutic approach in insulin resistance with acanthosis nigricans. International journal of clinical practice. 2002;56(8):578-81. Epub 2002/11/12.
37. R.H. Champion JLB, D.A. Burns, S.M. Breathnach. . Metabolic and nutritional disorders, in: Textbook of Dermatology. Blackwell Science O, UK, editor1998.
38. Bito T, Kawakami C, Shimajiri S, Tokura Y. Generalized eruptive xanthoma with prominent deposition of naked chylomicrons: evidence for chylomicrons as the origin of urate-like crystals. Journal of cutaneous pathology. 2010;37(11):1161-3. Epub 2010/09/21.
39. Parker F. Xanthomas and hyperlipidemias. Journal of the American Academy of Dermatology. 1985;13(1):1-30. Epub 1985/07/01.
40. Behm B, Schreml S, Landthaler M, Babilas P. Skin signs in diabetes mellitus. Journal of the European Academy of Dermatology and Venereology : JEADV. 2012;26(10):1203-11. Epub 2012/02/22.
41. Naik NS. Eruptive xanthomas. Dermatol Online J. 2001;7(2):11. Epub 2002/08/08.
42. Melin H. An Atrophic Circumscribed Skin Lesion in the Lower Extremities of Diabetics. Acta medica Scandinavica. 1964;176:SUPPL 423:1-75. Epub 1964/01/01.
43. Binkley GW. Dermopathy in the diabetic syndrome. Archives of dermatology. 1965;92(6):625-34. Epub 1965/12/01.
44. Vijayasingam SM TA, Chan HL. Non-infective skin associations of diabetes mellitus. Ann Acad Med Singapore. 1988;17:526-35.
45. Lee CH, Tey BH, Chew W. Epidemiology of diabetes mellitus in a regional hospital medical unit. Ann Acad Med Singapore. 1993;22(6):864-9. Epub 1993/11/01.
46. Romano G, Moretti G, Di Benedetto A, Giofre C, Di Cesare E, Russo G, et al. Skin lesions in diabetes mellitus: prevalence and clinical correlations. Dia- betes research and clinical practice. 1998;39(2):101-6. Epub 1998/05/23.
47. Shemer A, Bergman R, Linn S, Kantor Y, Friedman-Birnbaum R. Diabetic dermopathy and internal complications in diabetes mellitus. International journal of dermatology. 1998;37(2):113-5. Epub 1998/05/16.
48. Morgan AJ, Schwartz RA. Diabetic dermopathy: A subtle sign with grave implications. Journal of the American Academy of Dermatology. 2008;58(3):447-51. Epub 2007/12/25.
49. Chishiki M, Ohnishi Y, Kawada A, Tajima S, Ishibashi A. Diabetic pigmented spots on the extrapretibial region: immunohistochemical study of type IV collagen in dermal vessel wall. European journal of dermatology : EJD. 1998;8(8):560-2. Epub 1999/01/16.
50. Ahmed I, Goldstein B. Diabetes mellitus. Clinics in dermatology. 2006;24(4):237-46. Epub 2006/07/11.
51. Ngo BT, Hayes KD, DiMiao DJ, Srinivasan SK, Huerter CJ, Rendell MS. Manifestations of cutaneous diabetic microangiopathy. American journal of clinical dermatology. 2005;6(4):225-37. Epub 2005/08/03.
52. Bolognia JL. Jorizzo JL RR. Dermatology Spain e, editor2008.
53. Saray Y, Seckin D, Bilezikci B. Acquired perforating dermatosis: clinico- pathological features in twenty-two cases. Journal of the European Academy of Dermatology and Venereology : JEADV. 2006;20(6):679-88. Epub 2006/07/14.
54. AM F. Acquired perforating dermatosis in renal and diabetic patients. . Lan- cet. 1997;349:895–6.
2. www.who.int/diabetes/global-report/es/.
3. Perez MI, Kohn SR. Cutaneous manifestations of diabetes mellitus. Journal of the American Academy of Dermatology. 1994;30(4):519-31; quiz 32-4. Epub 1994/04/01.
4. Shahzad M, Al Robaee A, Al Shobaili HA, Alzolibani AA, Al Marshood AA, Al Moteri B. Skin manifestations in diabetic patients attending a diabetic clinic in the Qassim region, Saudi Arabia. Medical principles and practice: international journal of the Kuwait University, Health Science Centre. 2011;20(2):137-41. Epub 2011/01/22.
5. Murphy-Chutorian B, Han G, Cohen SR. Dermatologic manifestations of diabetes mellitus: a review. Endocrinology and metabolism clinics of North America. 2013;42(4):869-98. Epub 2013/11/30.
6. Reid SD, Ladizinski B, Lee K, Baibergenova A, Alavi A. Update on necrobiosis lipoidica: a review of etiology, diagnosis, and treatment options. Journal of the American Academy of Dermatology. 2013;69(5):783-91. Epub 2013/08/24.
7. Peyri J, Moreno A, Marcoval J. Necrobiosis lipoidica. Seminars in cutaneous medicine and surgery. 2007;26(2):87-9. Epub 2007/06/05.
8. Boateng B, Hiller D, Albrecht HP, Hornstein OP. [Cutaneous microcirculation in pretibial necrobiosis lipoidica. Comparative laser Doppler flowmetry and oxygen partial pressure determinations in patients and healthy probands]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. 1993;44(9):581-6. Epub 1993/09/01. Kutane Mikrozirkulation bei pratibialer Nekrobiosis lipoidica. Vergleichende Laser-Doppler-Fluxmetrie und Sauerstoffpartialdruckmessungen bei Patienten und Hautgesunden.
9. Ngo B, Wigington G, Hayes K, Huerter C, Hillman B, Adler M, et al. Skin blood flow in necrobiosis lipoidica diabeticorum. International journal of dermatology. 2008;47(4):354-8. Epub 2008/04/02.
10. Oikarinen A, Mortenhumer M, Kallioinen M, Savolainen ER. Necrobiosis lipoidica: ultrastructural and biochemical demonstration of a collagen de- fect. The Journal of investigative dermatology. 1987;88(2):227-32. Epub 1987/02/01.
11. Ullman S, Dahl MV. Necrobiosis lipoidica. An immunofluorescence study. Archives of dermatology. 1977;113(12):1671-3. Epub 1977/12/01.
12. Roche. E VJ, Velasco. M. Familial necrobiosis lipoidica not associated with diabetes. Dermatology Online Journal. 2007;3 (13):26
13. Sibbald. C RS, Alavi. F. Necrobiosis Lipoidica Dermatol Clin. 2015;33:343- 60.
14. Lynch JM, Barrett TL. Collagenolytic (necrobiotic) granulomas: part II-- the ‘red’ granulomas. Journal of cutaneous pathology. 2004;31(6):409-18. Epub 2004/06/10.
15. Thornsberry LA, English JC, 3rd. Etiology, diagnosis, and therapeutic management of granuloma annulare: an update. American journal of clinical dermatology. 2013;14(4):279-90. Epub 2013/05/23.
16. Piette EW, Rosenbach M. Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics. Journal of the American Academy of Dermatology. 2016;75(3):457-65. Epub 2016/08/21.
17. Dahl MV, Ullman S, Goltz RW. Vasculitis in granuloma annulare: histopathology and direct immunofluorescence. Archives of dermatology. 1977;113(4):463-7. Epub 1977/04/01.
18. Piette EW, Rosenbach M. Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. Journal of the American Academy of Dermatology. 2016;75(3):467-79. Epub 2016/08/21.
19. Chaitra V, Inchara YK, Rajalakshmi T, Antony M. Granuloma annulare - histology reconsidered. Indian journal of dermatology, venereology and leprology. 2010;76(5):568-9. Epub 2010/09/10.
20. Larsen K, Jensen T, Karlsmark T, Holstein PE. Incidence of bullosis diabeticorum--a controversial cause of chronic foot ulceration. International wound journal. 2008;5(4):591-6. Epub 2008/11/14.
21. Riad. H. AH, Mansour. K., Mannai. H., Sada. H., Shaikha. S. Dosari. S. Pruritic Vesicular Eruption on the Lower Legs in a Diabetic Female. Case Report. Case Reports in Dermatological Medicine. 2013;2013(641416):4.
22. Bolognia. L. JJL, Rapini. R. P. Other vesiculobullous diseases. Dermatology2008.
23. Lipsky BA, Baker PD, Ahroni JH. Diabetic bullae: 12 cases of a purportedly rare cutaneous disorder. International journal of dermatology. 2000;39(3):196-200. Epub 2000/04/12.
24. Jung SE, Kim YC. Scleredema of Buschke Following Streptococcal Infection. Annals of dermatology. 2015;27(4):478-80. Epub 2015/08/15.
25. Parmar RC, Bavdekar SB, Bansal S, Doraiswamy A, Khambadkone S. Scleredema adultorum. Journal of postgraduate medicine. 2000;46(2):91-3. Epub 2000/10/03.
26. All MCe. Scleredema diabeticorum in a patient with type 2 diabetes mel- litus. Case Rep Endocrinol. 2011;2011:560.
27. Pitarch. G. TA, Martínez-Aparicio. A., Vilata J., Fortea J. Escleredema de Buschke asociado a diabetes mellitus. Estudio de cuatro casos. Actas Der- mosifiliogr 2005;96(1):46-9.
28. Kovary PM, Vakilzadeh F, Macher E, Zaun H, Merk H, Goerz G. Monoclonal gammopathy in scleredema. Observations in three cases. Archives of dermatology. 1981;117(9):536-9. Epub 1981/09/01.
29. Besson C. A. KMC, Jacquet. P., Andrac, L., Sayag. J. Electron-beam therapy in scleredema adultorum with associated monoclonal hypergammaglobulinaemia. Br J Dermatol 1994;130(3):394–7.
30. Mattheou-Vakali G, Ioannides D, Thomas T, Lazaridou E, Tsogas P, Minas A. Cyclosporine in scleredema. Journal of the American Academy of Dermatology. 1996;35(6):990-1. Epub 1996/12/01.
31. Grundmann-Kollmann M, Ochsendorf F, Zollner TM, Spieth K, Kaufmann R, Podda M. Cream PUVA therapy for scleredema adultorum. Br J Dermatol. 2000;142(5):1058-9. Epub 2000/05/16.
32. Phiske MM. An approach to acanthosis nigricans. Indian dermatology online journal. 2014;5(3):239-49. Epub 2014/08/29.
33. James WD ED, Berger TG. Andrews Diseases of the Skin. Dermatology. C, editor2011. 494-5 p.
34. Judge MR MW, Munro CS. Disorders of keratinization. Burns T BS, Cox N, Griffiths C, editors, editor2010.
35. Hermanns-Le T, Scheen A, Pierard GE. Acanthosis nigricans associated with insulin resistance : pathophysiology and management. American journal of clinical dermatology. 2004;5(3):199-203. Epub 2004/06/10.
36. Tankova T, Koev D, Dakovska L, Kirilov G. Therapeutic approach in insulin resistance with acanthosis nigricans. International journal of clinical practice. 2002;56(8):578-81. Epub 2002/11/12.
37. R.H. Champion JLB, D.A. Burns, S.M. Breathnach. . Metabolic and nutritional disorders, in: Textbook of Dermatology. Blackwell Science O, UK, editor1998.
38. Bito T, Kawakami C, Shimajiri S, Tokura Y. Generalized eruptive xanthoma with prominent deposition of naked chylomicrons: evidence for chylomicrons as the origin of urate-like crystals. Journal of cutaneous pathology. 2010;37(11):1161-3. Epub 2010/09/21.
39. Parker F. Xanthomas and hyperlipidemias. Journal of the American Academy of Dermatology. 1985;13(1):1-30. Epub 1985/07/01.
40. Behm B, Schreml S, Landthaler M, Babilas P. Skin signs in diabetes mellitus. Journal of the European Academy of Dermatology and Venereology : JEADV. 2012;26(10):1203-11. Epub 2012/02/22.
41. Naik NS. Eruptive xanthomas. Dermatol Online J. 2001;7(2):11. Epub 2002/08/08.
42. Melin H. An Atrophic Circumscribed Skin Lesion in the Lower Extremities of Diabetics. Acta medica Scandinavica. 1964;176:SUPPL 423:1-75. Epub 1964/01/01.
43. Binkley GW. Dermopathy in the diabetic syndrome. Archives of dermatology. 1965;92(6):625-34. Epub 1965/12/01.
44. Vijayasingam SM TA, Chan HL. Non-infective skin associations of diabetes mellitus. Ann Acad Med Singapore. 1988;17:526-35.
45. Lee CH, Tey BH, Chew W. Epidemiology of diabetes mellitus in a regional hospital medical unit. Ann Acad Med Singapore. 1993;22(6):864-9. Epub 1993/11/01.
46. Romano G, Moretti G, Di Benedetto A, Giofre C, Di Cesare E, Russo G, et al. Skin lesions in diabetes mellitus: prevalence and clinical correlations. Dia- betes research and clinical practice. 1998;39(2):101-6. Epub 1998/05/23.
47. Shemer A, Bergman R, Linn S, Kantor Y, Friedman-Birnbaum R. Diabetic dermopathy and internal complications in diabetes mellitus. International journal of dermatology. 1998;37(2):113-5. Epub 1998/05/16.
48. Morgan AJ, Schwartz RA. Diabetic dermopathy: A subtle sign with grave implications. Journal of the American Academy of Dermatology. 2008;58(3):447-51. Epub 2007/12/25.
49. Chishiki M, Ohnishi Y, Kawada A, Tajima S, Ishibashi A. Diabetic pigmented spots on the extrapretibial region: immunohistochemical study of type IV collagen in dermal vessel wall. European journal of dermatology : EJD. 1998;8(8):560-2. Epub 1999/01/16.
50. Ahmed I, Goldstein B. Diabetes mellitus. Clinics in dermatology. 2006;24(4):237-46. Epub 2006/07/11.
51. Ngo BT, Hayes KD, DiMiao DJ, Srinivasan SK, Huerter CJ, Rendell MS. Manifestations of cutaneous diabetic microangiopathy. American journal of clinical dermatology. 2005;6(4):225-37. Epub 2005/08/03.
52. Bolognia JL. Jorizzo JL RR. Dermatology Spain e, editor2008.
53. Saray Y, Seckin D, Bilezikci B. Acquired perforating dermatosis: clinico- pathological features in twenty-two cases. Journal of the European Academy of Dermatology and Venereology : JEADV. 2006;20(6):679-88. Epub 2006/07/14.
54. AM F. Acquired perforating dermatosis in renal and diabetic patients. . Lan- cet. 1997;349:895–6.
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